Protein Alignment Cdk12 and pct-1

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_001379548.1
• Gene: pct-1 / 177615
• WormBaseID: WBGene00003961
• Length: 667
• Species: Caenorhabditis elegans
• Alignment Length: 655
• Identity: 175/655 - (26%)
• Similarity: 281/655 - (42%)
• Gaps: 161/655 - (24%)

  Fly   517 SPSSASSES---SASRSRSPTSRDLKHKREEYIKKISETSLFAELVKDRHKRQKALKEIIERQEE 578
            ||:..::::   |.:.|:|...:..|...|:.::|:.::|.||..:.....|:::.::..||...
 Worm   149 SPTGVTTQTTPPSNNTSKSKKKKKRKSDEEDGLRKMKKSSTFASFLNMFVSRRRSGRDSGERLMS 213

  Fly   579 NSNSNSNGALTINDNSSSVDGNTPNAADGRSAPGSGTPAAASTTSNGLQALGSKPDLDLNNIPMP 643
            .|......:::::....|:                              .|||
 Worm   214 RSTCMLRPSISLSVVQESM------------------------------ILGS------------ 236

  Fly   644 NKQNDSVVSNPASNADVPDSVAQLKQPLLVPPFSASKNNIKPKSLTSLPLPPGMNVLDLAGARSP 708
              ..:||..:|.::...|..         |||....  |:|.:..|               ||..
 Worm   237 --DGESVEVSPCTSDQTPTG---------VPPRYIV--NVKMRQKT---------------ARKW 273

  Fly   709 SPGQKKESDEKNVTSSGSANKSVLNLPMPPVIPGSEELSGDDDVIDSPEDFDAPAVGTVHGHGGG 773
            |    :|..:|.::....     |.||:..|           |.::.....|.|
 Worm   274 S----EEEIQKRLSLPAD-----LRLPVAVV-----------DKLNRTPTLDQP----------- 307

  Fly   774 PGTTRQRPVILNRRDSRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLE 838
                      |.|::.|.::.:.|...::.:|.:.::|||||..|::.|...||..||||::|||
 Worm   308 ----------LTRKNRRASLSEIGFGKLETYEKLDKLGEGTYATVFRGRSILTNKFVALKEIRLE 362

  Fly   839 HEKEGFPITAVREIKILRQLNHRNIVNLHEIV-TDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLE 902
            .| ||.|.||:||:.:||.|.|.|:|.||:|: ||:           ...|||||:|.||...::
 Worm   363 QE-EGAPCTAIREVSLLRNLRHANVVTLHDIIHTDR-----------LLTLVFEYVDRDLKQYMD 415

  Fly   903 SGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRE 967
            |........|....:.|||.||.|||::..||||:|..|:|:..:|::|||||||||..:..  .
 Worm   416 SCNNAMQMNNIRLFLYQLLRGLAYCHQRRVLHRDLKPQNLLITAKGELKLADFGLARAKSVP--T 478

  Fly   968 RPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGS 1032
            :.|:|:|:|||||||::|||...|...||:|..||||.|:...|.||.......||..|.:..||
 Worm   479 KTYSNEVVTLWYRPPDVLLGSTDYSTHIDMWGVGCILFEMIAGRALFPGGTPTEQLGLIFRTLGS 543

  Fly  1033 PVPAVWPNVIKLPLFHTLKQKKTHRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPW 1097
            |.|...|.:.:.|.|:....:..:...|......:.|...:||.|.|..:...|::|.:|::.|:
 Worm   544 PRPDRHPTICEKPTFYPYANRHYNPDPLCRQIPRIDAHGFELLMKFLQYEGKDRVSAAEAVKHPF 608

  Fly  1098 LRKINPDEMPTPQLPTWQDCHELWSKKRRRQMREQQESLPP-------TVIASTKY----QQHGA 1151
            ||.|           ..:.||          :|::|..|..       .::||..:    :.|..
 Worm   609 LRTI-----------AVKCCH----------LRDEQSVLEADGIHIERELLASDHHHSSRRHHRG 652

  Fly  1152 TMVGD 1156
            |:|.|
 Worm   653 TLVKD 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	117/302 (39%)
pct-1	NP_001379548.1	STKc_PCTAIRE_like	327..609	CDD:270835	116/295 (39%)