Protein Alignment Cdk12 and cdk-11.1

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_495617.1
• Gene: cdk-11.1 / 174244
• WormBaseID: WBGene00015203
• Length: 719
• Species: Caenorhabditis elegans
• Alignment Length: 898
• Identity: 225/898 - (25%)
• Similarity: 355/898 - (39%)
• Gaps: 284/898 - (31%)

  Fly   320 VSAHHRSSHDHG----YQGRYSGAGSSSHD-------------------TRKVKRLSPELD---- 357
            :|.|..||||.|    ...:.|...|||.:                   :|..||.:.|.|
 Worm     1 MSDHLGSSHDEGELSDESHKKSQRASSSDEPNPAKSNKGLESKMRESILSRLSKRKNSESDDDTT 65

  Fly   358 --RYNHQP-STPPHKRRKFSDGREVGLGNFEHSRHHSGKYERYSRDRYSRRSSRSPSVQHS---- 415
              |::.|| :....|..::.|            :....|.|:..||  .||..|.|..:..
 Worm    66 EQRFSIQPKNAQKAKEDRYRD------------KERDKKREKDKRD--DRRDVRGPDARQKDRDF 116

  Fly   416 RSRQSPSGGLSSGSNAFRHGGSHKHKYGTTVSSTPSHTTRTSKRASGTGTSGDRYSRSPRTSSRY 480
            :.||..||         |....|:|:
 Worm   117 KGRQERSG---------RDQKVHEHR--------------------------------------- 133

  Fly   481 MESSPPSPVGASGSHHYHHRRSPRMRQRTRGDSRRRSPSSASSESSASRSRSPTSRDLKHKRE-E 544
                          ||:|||:......||...:|.|| |...||              ||||. :
 Worm   134 --------------HHHHHRKHETDGHRTNRSNRDRS-SERDSE--------------KHKRHID 169

  Fly   545 YIKKISETSLFAELVKDRHKRQK-----ALKEIIER-QEENSNSNSNGALTINDNSSSVDGNTPN 603
            ..||.|.||  .:..|..||:.|     |..::.:| .:.|.....:..|.|.|...|
 Worm   170 RHKKSSTTS--PDNDKSPHKKSKHTDVPADAKLFDRILDPNYKKKDDDVLVIEDVEMS------- 225

  Fly   604 AADGRSAPGSGTPAAASTTSNGLQALGSKPDLDLNNI----PMPNKQNDSVVSNPASNADVPDSV 664
                                 .::.|..|.:.::...    |...|:.....|:|.|:.|
 Worm   226 ---------------------PIEILEEKEEKEIVEFTIDSPAGPKKYSKFESDPESDHD----- 264

  Fly   665 AQLKQPLLVPPFSASKNNIKPKSLTSLPLPPGMNVLDLAGARSPSPGQKKESDEKNVTSSGSANK 729
                             :.|||                      |||:.::.|:
 Worm   265 -----------------DTKPK----------------------SPGKAEDDDD----------- 279

  Fly   730 SVLNLPMPPVIPGSEELSGDDD-VIDSPEDFDAPAVGTVHGHGGGPGTTRQRPVILNRRDSRNNV 793
             |:.: :...:...::...|:| .:.:|||.:...:           |..::.:.......|.::
 Worm   280 -VIEV-LDDALHSDDDADSDEDKYLKTPEDREWEEM-----------TETEQRLHKEAMKKRASM 331

  Fly   794 RD--------------WGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGF 844
            :.              .|.|.:|.:|.:.::.|||:|.||:.:|..|:::||||::::|.|||||
 Worm   332 KQKTLIAQLPVFYPGLMGCRNIDEYECVNRVDEGTFGVVYRGKDKRTDEIVALKRLKMEKEKEGF 396

  Fly   845 PITAVREIK-ILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDF 908
            ||||:|||. :|:..||.||||:.||:...      ..||  .|:..|:::||:..||:: |...
 Worm   397 PITALREINMLLKAGNHPNIVNVKEILLGS------NMDK--IYMAMEFVEHDMKSLLDT-MSRR 452

  Fly   909 NEE----NNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERP 969
            |:.    ...::::|||.|:.:.||...||||:|.||:||:::|.:|:|||||||.|.  |..:.
 Worm   453 NKRFSIGEQKTLLQQLLSGIEHMHKLWILHRDLKTSNLLMSHKGILKIADFGLAREYG--DPLKK 515

  Fly   970 YTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPV 1034
            :|:.|:|||||.||||||...|...:|:||.|||:.|..:.:|||....|:.|::.|....|:|.
 Worm   516 FTSIVVTLWYRSPELLLGTRLYSTPVDMWSVGCIMAEFILLKPLFPGRGELEQIKKIFMEMGTPT 580

  Fly  1035 PAVWPNVIKLPLFHTLKQKKTHRRRLREDF---EFMPAPALDLLDKMLDLDPDKRITAEDALRSP 1096
            .::||.|.:|..:..|..:|....:||:.|   ..:......||:.:|.|||..|.:|..||...
 Worm   581 ESIWPGVTELDGWKALTFEKYPYNQLRKRFLAGRLLNDTGFKLLNGLLTLDPKNRFSATQALDHE 645

  Fly  1097 WLRKINPDEMPTPQLPTWQDCHELWSKKRRRQMREQQESLPPTVIASTKYQQH 1149
            |..: .|..:|..:.||:             ..:.:|...||.  |..|.|::
 Worm   646 WFTE-EPYPVPPEEFPTF-------------PAKSEQNKAPPP--AKQKQQEN 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	122/309 (39%)
cdk-11.1	NP_495617.1	STKc_CDC2L1	350..647	CDD:173741	121/307 (39%)