Protein Alignment Cdk12 and cdk-2

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_001021537.2
• Gene: cdk-2 / 171911
• WormBaseID: WBGene00019362
• Length: 338
• Species: Caenorhabditis elegans
• Alignment Length: 299
• Identity: 120/299 - (40%)
• Similarity: 175/299 - (58%)
• Gaps: 27/299 - (9%)

  Fly   804 FEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHE 868
            |..:.:|||||||.|:||.....|...|||.:|.:.::||.|.|.:|||..::.|.|.|||.|.:
 Worm    15 FCSLRRIGEGTYGVVFKAIHVRDNVKCALKMIRTDRDEEGIPSTCLREISCIKDLQHDNIVTLFD 79

  Fly   869 IVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNA--------SIMKQLLDGLN 925
            |:        :...|  .|:|||::|.||..|||     ..|..|:        |.|.|||..|:
 Worm    80 II--------YANSK--LYMVFEFIDRDLKNLLE-----MLEPTNSVLPPNYVKSFMWQLLSALS 129

  Fly   926 YCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEER 990
            |||.:..:|||:|..|||:::.|.:|:|||||||.::...|.  ||::|:||||||||:|||.:|
 Worm   130 YCHLRRIVHRDLKPQNILVSDSGVIKIADFGLARNFSFPSRN--YTHEVVTLWYRPPEILLGSQR 192

  Fly   991 YGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTL-KQKK 1054
            |..|:|:||.|||..|:...:|||....|::||..|.:|.|:|....||.|...|.:..: .|..
 Worm   193 YSTSLDMWSLGCIFSEIASNKPLFPGECEISQLFKIFEIVGTPNIKSWPGVDSFPHYKAVFPQWP 257

  Fly  1055 THRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDAL 1093
            .:.::| |:...:....||:|.::|...|::|:||:.||
 Worm   258 VNLKKL-EETSCLTGNGLDVLREILRYPPERRLTAKGAL 295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	120/299 (40%)
cdk-2	NP_001021537.2	STKc_CDK_like	15..300	CDD:270823	120/299 (40%)