Protein Alignment Cdk12 and cdk-14

DIOPT Version :9

• Sequence 1: NP_001262167.1
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_490783.3
• Gene: cdk-14 / 171672
• WormBaseID: WBGene00022519
• Length: 534
• Species: Caenorhabditis elegans
• Alignment Length: 650
• Identity: 175/650 - (26%)
• Similarity: 261/650 - (40%)
• Gaps: 205/650 - (31%)

  Fly   488 PVGASGS-HHYHHRRSPRMRQRTRGDSRRR----SPSSASSESSASRSRSPTSRDLKHKREEYIK 547
            |:.||.| ...||.:...:|.....::..|    ||........:..:|.|:|
 Worm    21 PMRASCSLSMIHHPQLTAVRSSKSSENLHRITTMSPQRIQDVDGSPSTRKPSS------------ 73

  Fly   548 KISETSLFAELVKDRHKRQKALKEIIERQEENSNSNS-------NGALTINDNSSSVDGNTPNAA 605
                 |:|. |.:.|:|.:|        .:.|....|       ||.   |:.:.|...|..|.|
 Worm    74 -----SIFT-LRRSRNKEKK--------YKNNGGGGSTKSPISKNGT---NEMTQSWHSNHVNGA 121

  Fly   606 DGRSAPGSGTPAAASTTSNGLQALGSKPDLDLNNI-PMPNKQNDSVVSNPASNADVPDSVAQLKQ 669
                :.|||:              ||.|:....|| ...::|:.|..:||:.....
 Worm   122 ----SSGSGS--------------GSTPEHHNKNIFSFLSRQSRSRSNNPSETMST--------- 159

  Fly   670 PLLVPPFSASKNNIKPKSLTSLPLPPGMN-VLDLAGARSPSPGQKKESDEKNVTSSGSANKSVLN 733
               ||   .:||:      .|:|.||..| |.|....|...| :....|...:|
 Worm   160 ---VP---LNKNS------PSMPPPPSSNTVADFTHLRRRRP-RSAHYDPNTIT----------- 200

  Fly   734 LPMPPVIPGSEELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTTRQRPVILNRRDSRNNVRDWGE 798
                  :|..||:        :|:|.:
 Worm   201 ------LPAKEEV--------TPQDVN-------------------------------------- 213

  Fly   799 RCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNI 863
               |:::.|.::|||:|..|||........:||||:::|:.: ||.|.||:||..:||.|.|.||
 Worm   214 ---DLYKRIDKLGEGSYATVYKCESKLDGSIVALKEIKLQFQ-EGLPFTAIREASLLRNLRHANI 274

  Fly   864 VNLHEIVTDKQDAVEFRKDKGSFY------LVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLD 922
            |:||:|                ||      .|||||..||...||..:...:..:...::.|||.
 Worm   275 VSLHDI----------------FYQHHQLTFVFEYMKMDLSKYLEQNVYGLDSIDIKLLLFQLLR 323

  Fly   923 GLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLG 987
            ||::||:|..||||:|..|:|::..|.:|||||||||..:..  .|.|:::|:|||||||::|:|
 Worm   324 GLDFCHRKKILHRDLKPQNLLLDEDGVLKLADFGLARAKSVP--SRTYSHEVVTLWYRPPDVLMG 386

  Fly   988 EERYGPSIDVWSCGCILGELFVKRPLFQANAE------MAQLETISKICGSPVPAVWPNVIKLP- 1045
            ...|..|:|:|..|||..|:.....||..:.:      ..||:.|..|.|:|....||.|..||
 Worm   387 STDYSTSLDMWGVGCIFAEICTGAALFPGSKDSHYPGTKDQLDMIFSIRGTPDEKKWPEVKTLPG 451

  Fly  1046 ----LFHTLKQKKTHRRRLREDFEFMPAPAL---------DLLDKMLDLDPDKRITAEDALRSPW 1097
                ||          .|.|| ..|:....:         :||..:|.|.|:.|::|..|:..|:
 Worm   452 YTPELF----------PRYRE-LSFIAVNPMFTKILKTGQELLGMLLQLRPESRVSAASAMLHPY 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	115/327 (35%)
		S_TKc	804..1098	CDD:214567	114/319 (36%)
cdk-14	NP_490783.3	PKc_like	216..506	CDD:389743	114/319 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910