DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdk12 and Cdk11b

DIOPT Version :9

Sequence 1:	NP_001262167.1	Gene:	Cdk12 / 40385	FlyBaseID:	FBgn0037093	Length:	1157	Species:	Drosophila melanogaster
Sequence 2:	NP_031687.2	Gene:	Cdk11b / 12537	MGIID:	88353	Length:	784	Species:	Mus musculus

Alignment Length:	1063	Identity:	254/1063 - (23%)
Similarity:	387/1063 - (36%)	Gaps:	346/1063 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 DSIDTDELEAEMKRQKRKKQKKEKHKHKSKKKSKKRKKKRAKSYSSIDSMSDNDINALLDRRYTP 185
            ||.....|:..::.:||:|:::||.:.|..|.|..|..||       ||:.:.:   |.|.|.
Mouse     6 DSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKR-------DSLEEGE---LRDHRM-- 58

  Fly   186 PTAPSKSNERTVSAAPSSFTPHNLKESSSPATPPPVRRPNTNSNYYGESSLETANSALGSNLQVT 250
                    |.|:                            .||.|..|.|:|.
Mouse    59 --------EITI----------------------------RNSPYRREDSMED------------ 75

  Fly   251 VTNKQSISNRLRSPPPSSRSSGNGPRFGNSPRTPPPSHYSSSGGGGVGSGSVVRDSRSSRYVNSP 315
             ..::..|..::.|...||......| .:..|.....|.|.|..||          :.:|.....
Mouse    76 -RGEEDDSLAIKPPQQMSRKEKAHHR-KDEKRKEKRRHRSHSAEGG----------KHARVKEKE 128

  Fly   316 HKEDVSAHHRSSHDHGYQGRYSGAGSSSHDTRKVKRLSPELDRYNHQPSTPPHKRRKFSDGREVG 380
            .:.:....||...|                  |.:|   |.:|         .|||:.:.
Mouse   129 REHERRKRHREEQD------------------KARR---EWER---------QKRREMAR----- 158

  Fly   381 LGNFEHSRHHSGKYE----RYSRDRYSRRSSRSPSVQHSRSRQSPSGGLSSGSNAFRHGGSHKHK 441
                ||||....:.|    :..|:|..|...:....|..|.|::                ..:.|
Mouse   159 ----EHSRRERDRLEQLERKRERERKLREQQKEQREQKERERRA----------------EERRK 203

  Fly   442 YGTTVSSTPSHTTRTSKRASGTGTSGDRYSRSPRTSSRYMESSPPSPVGASGSHHYHHRRSPRMR 506
            .........:|.....:..|..|..| .:||||        ..||......|.:     |.|...
Mouse   204 EREARREVSAHHRTMREEYSDKGKVG-HWSRSP--------LRPPRERFEMGDN-----RKPVKE 254

  Fly   507 QRTR-----------GDSRRRSPSSASSESSASRSRSPTSRDLKHKREEYIKKISETSLFAELVK 560
            ::..           .||.|:: |||.|.|:.|.|.|....:.:.:.||.....||.|...|..:
Mouse   255 EKVEERDLLSDLQDISDSERKT-SSAESSSAESGSGSEEEEEEEEEEEEEEGSTSEESEEEEEEE 318

  Fly   561 DRHKR-----------QKALKEII--ERQEENSNSNSNGALTINDNSSSVDGNTPNAADGRSAPG 612
            :..:.           :::.:|:.  |..|:....|.|..|.:.:  |..|.::.::.:|....|
Mouse   319 EEEEEEETGSNSEEASEQSAEEVSDEEMSEDEDRENENHILVVPE--SRFDRDSGDSEEGEEEVG 381

  Fly   613 SGTPAAASTTSNGLQALGSKPDLDLNNIPMPNKQNDSVVSNPASNADVPDSVAQLKQPLLVPPFS 677
            .|||.:::.|                       :.|.|..:||.      |..:|||.|
Mouse   382 EGTPQSSAPT-----------------------EGDYVPDSPAL------SPIELKQEL------ 411

  Fly   678 ASKNNIKPKSLTSLPLPPGMNVLDLAGARSPSPGQKKESDEKNVTSSGSANKSVLNLPMPPVIPG 742
                   ||.|.:|.
Mouse   412 -------PKYLPALQ-------------------------------------------------- 419

  Fly   743 SEELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTTRQRPVILNRRDSRNNVRDWGERCVDVFEMI 807
                                                                  |.|.|:.|:.:
Mouse   420 ------------------------------------------------------GCRSVEEFQCL 430

  Fly   808 AQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTD 872
            .:|.|||||.||:|:|..|:::||||::::|.||||||||::|||..:.:..|.|||.:.|||
Mouse   431 NRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIV-- 493

  Fly   873 KQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDI 937
                |....||  .|:|..|::|||..|:|:....|......::|.|||.|:.:.|....||||:
Mouse   494 ----VGSNMDK--IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLSGVKHLHDNWILHRDL 552

  Fly   938 KCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGC 1002
            |.||:|:::.|.:|:.||||||.|.:.  .:.||..|:|||||.||||||.:.|..::|:||.||
Mouse   553 KTSNLLLSHAGILKVGDFGLAREYGSP--LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGC 615

  Fly  1003 ILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRLREDF-EF 1066
            |.|||..::|||...:::.|:..|.|..|:|...:||....||....:...:.....||:.| ..
Mouse   616 IFGELLTQKPLFPGKSDIDQINKIFKDLGTPSEKIWPGYNDLPAVKKMTFSEYPYNNLRKRFGAL 680

  Fly  1067 MPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTP----QLPTWQDCHELWSKKRRR 1127
            :.....||::|.|...|.:||.|||.|:..:.|     |.|.|    ..|||.      :|..::
Mouse   681 LSDQGFDLMNKFLTYYPGRRINAEDGLKHEYFR-----ETPLPIDPSMFPTWP------AKSEQQ 734

  Fly  1128 QMREQQESLPPTVIASTKYQQHG 1150
            :::......||.  ....|.|.|
Mouse   735 RVKRGTSPRPPE--GGLGYSQLG 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	123/302 (41%)
Cdk12	NP_001262167.1	S_TKc	804..1098	CDD:214567	120/294 (41%)
Cdk11b	NP_031687.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..401		104/549 (19%)
		STKc_CDC2L1	421..712	CDD:173741	122/300 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	722..784		9/42 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920