Protein Alignment Cdk12 and cdk13

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_001353758.1
• Gene: cdk13 / 108178997
• ZFINID: ZDB-GENE-030131-4975
• Length: 1289
• Species: Danio rerio
• Alignment Length: 1107
• Identity: 422/1107 - (38%)
• Similarity: 559/1107 - (50%)
• Gaps: 262/1107 - (23%)

  Fly   110 ELWGREIYMSSDSIDTDELEAEMKRQKRKKQKKEKH---KHKSKKKSKKRKK-KRAKS------- 163
            |:.|||....|......:.||     :|.|.::|:|   |.:|...|.:||: ||.:.
Zfish     5 EIVGREGRGRSPPPQRSQREA-----RRSKSRRERHRDGKGRSASSSSRRKRHKRGREKQLQQPQ 64

  Fly   164 -YSSIDSMSDNDINALLDRRYTPPTAPSKSNERTVSAAPSSFTPHNLKESSSPATPPPVRRPNTN 227
             :...|::.|.|...|::  |...::.|:                  :.|.||:       |.|:
Zfish    65 PWQQQDALYDGDAGTLVE--YDDVSSQSE------------------RFSGSPS-------PRTD 102

  Fly   228 S---NYYGESSLETANSALGSNLQVTVTNKQSISNRLRSPPPSSRSSGNGPRFGNSPRTPPPSHY 289
            :   :...|:.|:...                    ..:|.....:|.:..|.|.:.|
Zfish   103 ALSVDRLSEAELQDCG--------------------YEAPAGREHNSSSRRRDGPAER------- 140

  Fly   290 SSSGGGGVGSGSVVRDSRSSRYVNSPHKEDVSAHHRSS-HDHGYQGRYSGAGSSS--HDTRKVK- 350
                         :|..:.::...|..::|.:...||. .:|...||...:.|.:  .::|:.|
Zfish   141 -------------IRSEKDAKRNRSGREQDAAFKSRSGVRNHDSNGRKPSSASQADKKESRRHKS 192

  Fly   351 RLSPELDRYNHQPST---PPHKRRKFSDGREVGLGNFEHSRHHSGKYERYSRDRYSRRSSRSPSV 412
            :..||.|    .||.   ||                           :.|..||...|:.|
Zfish   193 KPKPEKD----APSAYREPP---------------------------QAYRDDREELRAYR---- 222

  Fly   413 QHSRSRQSPSGGLSSGSNAFRHGGSHKHKYGTTVSSTPSH----TTRTSKRASGTGT-------- 465
                 |.||| ..::..||..:|.|:   ||  ..|.|::    ..|:.|:.|.|.|
Zfish   223 -----RSSPS-FKATADNASPYGTSY---YG--YQSPPANYQLIPWRSPKKQSPTSTYYRDPEMY 276

  Fly   466 --------SGDRYSRSP-----RTSSRYMESSPPSPVGASGSHHYHHRRS----PRMRQRTRGDS 513
                    ||.| .|||     |.|..|...||......:||.:...|||    |..|:..:..|
Zfish   277 AAYNALNSSGKR-KRSPASPYWRRSPSYGRHSPYEQGEFAGSPYGQRRRSRSPTPDTRRPVKSGS 340

  Fly   514 RRRSPSSASSES------SASRSR----SPTSRDLKHKREEYIKKISETSLFAELVKDRHKRQKA 568
            |...||:..|.|      |.||||    ||:|..||            :||.|||.|  .|:.||
Zfish   341 RSPYPSARHSRSRSRHRVSRSRSRPSSLSPSSLTLK------------SSLAAELSK--QKKAKA 391

  Fly   569 LKEIIERQEENSNSNSNGALTINDNSSSVDGNTPNAADGRSAPGSGTPAAASTTSNGLQALGSKP 633
            .:     .....||:||.:.....:|||.:...|:.....:|..:..|:.
Zfish   392 AE-----AARAKNSSSNASTPTKGSSSSSNAPQPSPVTNHAAKKTRPPSP--------------- 436

  Fly   634 DLDLNNIPMPNK--------QNDSVVSNPAS-NADV--PDSVAQLKQPLLVPPFSASKNNIKPKS 687
                   |.|.|        |..|.|..||. :|||  |...|:||:..........:..:.|..
Zfish   437 -------PPPEKGPRTPVCSQPQSPVERPAKRSADVPLPGRDAKLKEEKKKQAVKEKEKTVAPVV 494

  Fly   688 LTSLPLPPGMNVLD----LAGARSPSPGQKKESDEKNVTSSGSANKSVLNLPMPPVIPGSEELSG 748
            .|..|....|..|:    ::..:..|.|:|....|:.|.:..|      :||:||.:||....|
Zfish   495 ATHTPAANNMEHLEANDSVSSLKESSAGKKSSKPERKVRALLS------DLPLPPELPGLTPAS- 552

  Fly   749 DDDVIDSPEDFDAPAVGTVHGHGGGPGTTRQRPVILNRR--DSRNNVRDWGERCVDVFEMIAQIG 811
               .:..|::...||             .|:||.|...|  :.:....|||:||||.||:|...|
Zfish   553 ---PLSPPDEKKTPA-------------PRRRPKICGPRFGEIKETEIDWGKRCVDKFEIIGITG 601

  Fly   812 EGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDA 876
            ||||||||||:|..|.::||||||||::|||||||||:|||||||||||::|:|:.||||||:||
Zfish   602 EGTYGQVYKAKDKDTAELVALKKVRLDNEKEGFPITAIREIKILRQLNHKSIINMKEIVTDKEDA 666

  Fly   877 VEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSN 941
            ::|:.|||:|||||||||||||||||||:|.|||.:..|.|:|||:||:||||||||||||||||
Zfish   667 LDFKNDKGAFYLVFEYMDHDLMGLLESGLVHFNESHIKSFMRQLLEGLDYCHKKNFLHRDIKCSN 731

  Fly   942 ILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGE 1006
            ||:||:|::||||||||||||::: .||||||||||||||||||||||||.|:||||||||||||
Zfish   732 ILLNNKGQIKLADFGLARLYNSEE-SRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGE 795

  Fly  1007 LFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRLREDFEFMPAPA 1071
            ||.|:|:||||.|:||||.||:|||||.|||||:|||||.|:|:|.||.:||||||:|.|:|..|
Zfish   796 LFTKKPIFQANQELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFAFIPLMA 860

  Fly  1072 LDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPTWQDCHELWSKKRRRQMREQQESL 1136
            |||.|.||.|||.||.|||.||.|.:||.::|.:||.|.||.|||||||||||||||.:..:|..
Zfish   861 LDLFDHMLALDPSKRCTAEQALNSDFLRDVDPAKMPPPDLPLWQDCHELWSKKRRRQKQMPEELT 925

  Fly  1137 PP 1138
            .|
Zfish   926 AP 927

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	226/301 (75%)
cdk13	NP_001353758.1	STKc_CDK12	586..887	CDD:270847	226/301 (75%)