Protein Alignment Cdk12 and Cdk20

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_444410.1
• Gene: Cdk20 / 105278
• MGIID: 2145349
• Length: 346
• Species: Mus musculus
• Alignment Length: 319
• Identity: 115/319 - (36%)
• Similarity: 175/319 - (54%)
• Gaps: 20/319 - (6%)

  Fly   801 VDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVN 865
            :|.:.::.:||||.:|.|:||:...|.::||||||.|...::|.|..|:||||.|::
Mouse     1 MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGIPNQALREIKALQE-------- 57

  Fly   866 LHEIVTDKQDAVEFR---KDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYC 927
                :.|.|..|:.:   .....|.|.||:|..||..::.............|.::.||.|:.:|
Mouse    58 ----IEDSQYVVQLKAVFPHGAGFVLAFEFMLSDLAEVVRHAQRPLAPAQVKSYLQMLLKGVAFC 118

  Fly   928 HKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYG 992
            |..|.:|||:|.:|:|::..|::|:|||||||:::.|. .|.||::|.|.|||.||||.|..:|.
Mouse   119 HANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDG-GRLYTHQVATRWYRAPELLYGARQYD 182

  Fly   993 PSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHR 1057
            ..:|:|:.|||:|||....|||....::.||..:.:|.|:|.|.|||.:.:||.::.:..|:...
Mouse   183 QGVDLWAVGCIMGELLNGSPLFPGENDIEQLCCVLRILGTPSPRVWPEITELPDYNKISFKEQAP 247

  Fly  1058 RRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWL----RKINPDEMPTPQLP 1112
            ..|.|........|||||.:.|...|.:||.|..||...:.    ...:|.|:|.||.|
Mouse   248 VPLEEVLPDASPQALDLLGQFLLYPPRQRIAASQALLHQYFFTAPLPAHPSELPIPQRP 306

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	109/299 (36%)
Cdk20	NP_444410.1	STKc_CCRK	3..289	CDD:270826	108/298 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	298..324		5/9 (56%)