Protein Alignment Cdk12 and CDK9

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_001252.1
• Gene: CDK9 / 1025
• HGNCID: 1780
• Length: 372
• Species: Homo sapiens
• Alignment Length: 363
• Identity: 163/363 - (44%)
• Similarity: 229/363 - (63%)
• Gaps: 23/363 - (6%)

  Fly   801 VDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVN 865
            |..:|.:|:||:||:|:|:|||...|...||||||.:|:|||||||||:||||||:.|.|.|:||
Human    16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHENVVN 80

  Fly   866 LHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKK 930
            |.||...|  |..:.:.|||.||||::.:|||.|||.:.:|.|.......:|:.||:||.|.|:.
Human    81 LIEICRTK--ASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLLNGLYYIHRN 143

  Fly   931 NFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERP--YTNKVITLWYRPPELLLGEERYGP 993
            ..||||:|.:|:|:...|.:|||||||||.::.....:|  |||:|:|||||||||||||..|||
Human   144 KILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYRPPELLLGERDYGP 208

  Fly   994 SIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRR 1058
            .||:|..|||:.|::.:.|:.|.|.|..||..||::|||..|.|||||....|:..|:..|..:|
Human   209 PIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELVKGQKR 273

  Fly  1059 RLREDFE-FMPAP-ALDLLDKMLDLDPDKRITAEDALRSP--WLRKINPDEMPTPQLPTWQDCH- 1118
            ::::..: ::..| ||||:||:|.|||.:||.::|||...  |     .|.||: .|......|
Human   274 KVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFW-----SDPMPS-DLKGMLSTHL 332

  Fly  1119 ----ELWSKKRRR--QMREQ--QESLPPTVIASTKYQQ 1148
                |..:..||:  |:.:|  .:|..|.....|::::
Human   333 TSMFEYLAPPRRKGSQITQQSTNQSRNPATTNQTEFER 370

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	149/302 (49%)
CDK9	NP_001252.1	STKc_CDK9	6..315	CDD:270848	149/300 (50%)
		T-loop	166..191		12/24 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	343..372		7/28 (25%)