Protein Alignment Cdk12 and CDK3

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: NP_001249.1
• Gene: CDK3 / 1018
• HGNCID: 1772
• Length: 305
• Species: Homo sapiens
• Alignment Length: 311
• Identity: 126/311 - (40%)
• Similarity: 188/311 - (60%)
• Gaps: 22/311 - (7%)

  Fly   801 VDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVN 865
            :|:|:.:.:|||||||.||||::..|..:|||||:||:.|.||.|.||:|||.:|::|.|.|||.
Human     1 MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVR 65

  Fly   866 LHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMK----QLLDGLNY 926
            |.::|.:::          ..|||||::..||...::|..   ..|....::|    |||.|:::
Human    66 LLDVVHNER----------KLYLVFEFLSQDLKKYMDSTP---GSELPLHLIKSYLFQLLQGVSF 117

  Fly   927 CHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERY 991
            ||....:|||:|..|:|:|..|.:|||||||||.:...  .|.||::|:|||||.||:|||.:.|
Human   118 CHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVP--LRTYTHEVVTLWYRAPEILLGSKFY 180

  Fly   992 GPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTH 1056
            ..::|:||.|||..|:..::.||..::|:.||..|.::.|:|....||.|.:||.:.....|.|
Human   181 TTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWT- 244

  Fly  1057 RRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMP 1107
            |:.|.|....:.....|||.::|..||.:||||:.||..|:..  :|:..|
Human   245 RKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFS--SPEPSP 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	124/300 (41%)
CDK3	NP_001249.1	STKc_CDK2_3	3..286	CDD:270844	123/298 (41%)