Protein Alignment Cdk12 and CDK2

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: XP_011536034.1
• Gene: CDK2 / 1017
• HGNCID: 1771
• Length: 346
• Species: Homo sapiens
• Alignment Length: 362
• Identity: 131/362 - (36%)
• Similarity: 188/362 - (51%)
• Gaps: 75/362 - (20%)

  Fly   804 FEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHE 868
            |:.:.:|||||||.|||||:..|.::|||||:||:.|.||.|.||:|||.:|::|||.|||.|.:
Human     4 FQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLD 68

  Fly   869 IVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLE-SGMVDFNEENNASIMKQLLDGLNYCHKKNF 932
            ::          ..:...|||||::..||...:: |.:.........|.:.|||.||.:||....
Human    69 VI----------HTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRV 123

  Fly   933 LHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYGPSIDV 997
            ||||:|..|:|:|..|.:|||||||||.:...  .|.||::|:|||||.||:|||.:.|..::|:
Human   124 LHRDLKPQNLLINTEGAIKLADFGLARAFGVP--VRTYTHEVVTLWYRAPEILLGCKYYSTAVDI 186

  Fly   998 WSCGCILGELFV------------------------------------------------KRPLF 1014
            ||.|||..|:.:                                                :|.||
Human   187 WSLGCIFAEMHLVGTQHHARCCGEHRRNGRQSLCPLCSYLEVAASQGWGMTAVSTPYPVTRRALF 251

  Fly  1015 QANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHRRRLREDFEFMPAPALD-----L 1074
            ..::|:.||..|.:..|:|...|||.|..:|.:     |.:..:..|:||..: .|.||     |
Human   252 PGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDY-----KPSFPKWARQDFSKV-VPPLDEDGRSL 310

  Fly  1075 LDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQL 1111
            |.:||..||:|||:|:.||..|:.:.:.   .|.|.|
Human   311 LSQMLHYDPNKRISAKAALAHPFFQDVT---KPVPHL 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	128/347 (37%)
CDK2	XP_011536034.1	STKc_CDK2_3	3..334	CDD:270844	128/347 (37%)