Protein Alignment Cdk12 and LOC100536316

DIOPT Version :10

• Sequence 1: NP_649325.2
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: XP_021334474.1
• Gene: LOC100536316 / 100536316
• -ID: -
• Length: 482
• Species: Danio rerio
• Alignment Length: 491
• Identity: 159/491 - (32%)
• Similarity: 234/491 - (47%)
• Gaps: 105/491 - (21%)

  Fly   686 KSLTSLPLPPGMNVLD-LAGARSPSPGQKKESDEKNVTSSGSANKSV------------------ 731
            :||..||...|:...| :...:..|.|   |||:.:.|||......|
Zfish    23 ESLCDLPEHTGLEEGDEVTHGKMGSDG---ESDQASGTSSDEVQSPVRVRMRNLHQRISNEDINK 84

  Fly   732 -LNLPMPPVIPGS--EELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTTRQRPVILNRRDSRNNV 793
             |:||....:|..  ::.:.:....|.|                           |:||..|.::
Zfish    85 RLSLPADIRLPEGYLKKFASNSPPFDKP---------------------------LSRRLRRTSL 122

  Fly   794 RDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQL 858
            .:.|...::.:..:.::|||||..|||.|...|:::||||::|||:| ||.|.||:||:.:|:.|
Zfish   123 SEIGFGKLETYIKLDKLGEGTYATVYKGRSKLTDNLVALKEIRLEYE-EGAPCTAIREVSLLKNL 186

  Fly   859 NHRNIVNLHEIV-TDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMK---- 918
            .|.|||.||:|: |:|           ...|||||:|.||...|         :|..|||.
Zfish   187 KHANIVTLHDIIHTEK-----------CLTLVFEYLDRDLKQYL---------DNCGSIMSIYNV 231

  Fly   919 -----QLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLW 978
                 |||.||.|||.:..||||:|..|:|:|::|::|||||||||..:..  .:.::|:|:|||
Zfish   232 KIFLFQLLRGLAYCHSQKVLHRDLKPQNLLINDKGELKLADFGLARAKSVP--TKTFSNEVVTLW 294

  Fly   979 YRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIK 1043
            ||||::|||...|...||:|..|||..|:...||||..:....:|..|.:|.|||....||....
Zfish   295 YRPPDVLLGSTEYSTPIDIWGVGCIFYEMITGRPLFPGSTVEDELHLIFRILGSPTEDSWPEAYS 359

  Fly  1044 LPLFHTLKQKK-------THRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKI 1101
            ...|.:.:..:       ||..|:..|       ..|||.::|..|..:|::||.|||..:.|.:
Zfish   360 NENFLSYRFPQYDGEPLVTHAPRITND-------GHDLLCQLLQFDARRRVSAEAALRHVYFRDL 417

  Fly  1102 NPDEMPTPQLPTWQDCHELWSKKRRRQMREQQESLP 1137
            . |::  .|||   |...::|.|..|...:..:..|
Zfish   418 G-DKV--HQLP---DTTSIFSIKEIRLQNDPGKHFP 447

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_649325.2	STKc_CDK12	796..1098	CDD:270847	124/318 (39%)
LOC100536316	XP_021334474.1	Protein Kinases, catalytic domain	127..414	CDD:473864	123/316 (39%)