Protein Alignment Cdk12 and cdk13

DIOPT Version :9

• Sequence 1: NP_001262167.1
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: XP_002940845.2
• Gene: cdk13 / 100489599
• XenbaseID: XB-GENE-6040279
• Length: 1391
• Species: Xenopus tropicalis
• Alignment Length: 1160
• Identity: 428/1160 - (36%)
• Similarity: 566/1160 - (48%)
• Gaps: 271/1160 - (23%)

  Fly    74 AEDSSDPVAAGSRQTSSSEATNPREEPS-----QASNTSKDELWGREIYMSSDSI------DTDE 127
            :.:.:.|.|..|..:::|..:.....|:     :.|:..:.:...|:..|...|:      |.|:
 Frog     4 SSELNQPAALSSTSSAASSVSGQHPGPADDSRKRRSHHQRKKRRARQQAMLDCSVEPVGPTDGDD 68

  Fly   128 LEAEMK-----RQKRKKQKKEKHKHKSKKKSKKRK-KKRAKS--YSSIDSMSDNDINALLDRRYT 184
            .:|..:     |..|:::|:.|.:..|.::|..|| :.||.:  |..:.|:||.|
 Frog    69 SQAATRGRRHHRMHRERKKRRKDRGGSGRRSGLRKDRARAPTVEYDDVSSLSDGD---------- 123

  Fly   185 PPTAPSKSNERTVSAAPSSFTPHNLKESSSPATPPPVRRPNTNSNYYGESSLETANSALGSNLQV 249
                                    |.|.....|||                  .|.|.||..|
 Frog   124 ------------------------LSEGEQVPTPP------------------FAPSVLGLGL-- 144

  Fly   250 TVTNKQSISNRLRSP---PPSSRSSGNGPRFGNSPRTPPP--SHYSSSGGGGVGSGSVVRDSRSS 309
               |....|:|..||   ||                 |||  |.....|..|          ||.
 Frog   145 ---NASPASDRCPSPVGLPP-----------------PPPQVSLLRQRGDSG----------RSG 179

  Fly   310 RYVNSPHKEDVSAHHRSSHDHGYQGRYSGAGSSSHDTRKVKRLSPELDRYNHQPSTPPHKRRKFS 374
            |...|...|   :.||...|  .|.|..|.     :...:...:|.:.....:|.....|:.:|
 Frog   180 RRKTSRRPE---SKHRRRED--MQDRRRGG-----EIGDLLLPTPLMLASTWRPQCELGKKPEF- 233

  Fly   375 DGREVGLGNFEHSRHHSGKYERYSRDRYSRRSSRSPSVQHSRSRQSPSGGLSSGSNAFRHGGSHK 439
              |.|.|  |...|..:..|.:.....|..:..||..:|                      |:|:
 Frog   234 --RPVPL--FRPKREEALAYNKQPPKAYRDKGFRSSVLQ----------------------GNHR 272

  Fly   440 HKYGTTVSSTPSHTTRTSKRASGTGTSGDRYS-RSPRTSSR-YMESSPP------SPVGASGSHH 496
            .|     |.:|       .|:...|.||.|.: |||....| ..|:|||      ||....|...
 Frog   273 KK-----SLSP-------VRSPSPGYSGHRQNRRSPSFGVRDKNETSPPARRRSRSPYSPGGRRT 325

  Fly   497 YHHR-RSPRMRQRTRGDSRRRSPSSASSESSASRSRSPTSRDLKHKREEYIKKISETSLFAELVK 560
            ...| |||...:.:|..||.|...|.|.:||.    ||:...||            :||.|||
 Frog   326 ARSRSRSPYKPRHSRSRSRHRGSKSRSRQSSI----SPSKLTLK------------SSLAAEL-- 372

  Fly   561 DRHKRQKALKEIIERQEENSNSNS---NGALTINDNSSSVDGNTPNAADGRSAPGSGTPAAASTT 622
              :|.:||.:....|.:..:...|   .|.|....||.  ..||  |.:.:........:.:..:
 Frog   373 --NKNKKAREAEAARAQAKAGKISTPVKGQLEAVSNSQ--QSNT--AKEQKKVKTDRVQSPSQKS 431

  Fly   623 SNGLQALGSKPDLDLNNIPMPNKQNDSVVSNPASNADVPDSVAQLKQPLLVPPFSASKNN----- 682
            ......:.|:.....||:|   .:..:..|:..|..|:      :||........|..:|
 Frog   432 EKAKVKVQSQESCRENNLP---AEKTAKSSSKVSKIDL------VKQETCTSKEKAKTHNSDAAT 487

  Fly   683 --------IKPKSLTSLPLPPGMNVLDLAGA--RSPSPGQ--KKESDEKNVTSSGSANKSVLNLP 735
                    :...:|.||||||   ||...|.  |...||:  |||.:.|..|       .:.:||
 Frog   488 TEKIKCLALLTSALPSLPLPP---VLSSHGESFRGCVPGKSVKKEMERKLRT-------LLSDLP 542

  Fly   736 MPPV-IPGSEELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTTRQRPVILNRR--DSRNNVRDWG 797
            :||: .|.||    .:||.||||            ........::||.|...|  :......|||
 Frog   543 LPPLPAPQSE----SEDVSDSPE------------RKKNQSRNKRRPKICGPRCGEILEKEIDWG 591

  Fly   798 ERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRN 862
            :||||.|::|..||||||||||||:|..|.:|||||||||::|||||||||:|||||||||||::
 Frog   592 KRCVDKFDIIGIIGEGTYGQVYKAKDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLNHQS 656

  Fly   863 IVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYC 927
            |:|:.||||||:||::|:||||:|||||||||||||||||||:|.|||.:..|.|:||::||:||
 Frog   657 IINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNEHHIKSFMRQLMEGLDYC 721

  Fly   928 HKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPELLLGEERYG 992
            ||:|||||||||||||:||||::|||||||||||:::: .||||||||||||||||||||||||.
 Frog   722 HKRNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEE-SRPYTNKVITLWYRPPELLLGEERYS 785

  Fly   993 PSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKTHR 1057
            |:||||||||||||||.|:|:||||.|:||||.||::||||.|||||:|||||.|:|:|.||.:|
 Frog   786 PAIDVWSCGCILGELFTKKPIFQANQELAQLELISRMCGSPCPAVWPDVIKLPYFNTMKPKKQYR 850

  Fly  1058 RRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPTWQDCHELWS 1122
            |:|||:|.|:|..||||.|.||.|||:||.|||.||...:||.::|.:|..|.||.|||||||||
 Frog   851 RKLREEFVFIPNAALDLFDHMLALDPNKRCTAEQALLCEFLRDVDPSKMTPPDLPLWQDCHELWS 915

  Fly  1123 KKRRRQ----------------------MREQQESLPPTVIASTKYQQHGATMVG 1155
            ||||||                      |.:.:.|.|..:..|::.:..|...||
 Frog   916 KKRRRQKQLGMGDDLTVPKVPRKDSSLGMDDSRNSTPQGMQISSQLKTQGFPSVG 970

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	223/301 (74%)
		S_TKc	804..1098	CDD:214567	217/293 (74%)
cdk13	XP_002940845.2	STKc_CDK12	590..891	CDD:270847	223/301 (74%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	465	1.000	Domainoid score	I463
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	582	1.000	Inparanoid score	I996
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	1	1.000	-	-		FOG0000444
OrthoInspector	1	1.000	-	-		otm48102
Panther	1	1.100	-	-	O	PTHR24056
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R186
SonicParanoid	1	1.000	-	-		X546
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190