Protein Alignment Cdk12 and cdk12

DIOPT Version :9

• Sequence 1: NP_001262167.1
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: XP_003200579.2
• Gene: cdk12 / 100149834
• ZFINID: ZDB-GENE-081104-294
• Length: 1293
• Species: Danio rerio
• Alignment Length: 1200
• Identity: 420/1200 - (35%)
• Similarity: 566/1200 - (47%)
• Gaps: 333/1200 - (27%)

  Fly     4 SSAAATALVEYSDVSSE--------------DFSDQEAGDLDADAGKGAGNIKKPKPAPDNQFSK 54
            ::.|...||||.|:||:              |..|.|..|| :|.|:....:.|     :|:..|
Zfish    76 AAGAIKPLVEYDDISSDSDTFLDSPATGNPVDTRDAEQLDL-SDYGEVVAGVAK-----ENRTHK 134

  Fly    55 GRLDAKPDKEGYDNYRSRRAEDSSDPVAAGSRQTSSSEATNPREEPSQASNTSKDELWGREIYMS 119
            .:...|..|   |.:|.|.:                      .|.|..|..:.||
Zfish   135 RKRSRKKSK---DRHRVRES----------------------AERPVGAKKSIKD---------- 164

  Fly   120 SDSIDTDELEAEMKRQKRKKQKKEKHKHKSK-------KKSKKRKKKRAKSYSSIDSMSDNDINA 177
                          |::..|:.::|.|.::.       ..|::..:..||.....:|:|.:.:.:
Zfish   165 --------------RERVSKESRKKVKERASPVACLAASSSRRSGETGAKKLGGGESVSSSAVQS 215

  Fly   178 LLDRRYTPPTAPSKSNERTVSAAPSSFTPHNLKESSSPATPPPVRRPNTNSNYYGESSLETANSA 242
            .:            |...:.|:|.||.:..:::.|.|       |:....:..|.|..
Zfish   216 AV------------SLGSSASSASSSISKESVRSSKS-------RKEKRRNEEYEEDR------- 254

  Fly   243 LGSNLQVTVTNKQSISNRLRSPPPSSRSSGNGPRFGNSPRTPPPSHYSSSGGGGVGSGSVVRDSR 307
                     :::::..:|..||...|:|.          ||
Zfish   255 ---------SHRKAAKSRKSSPKGKSQSR----------RT------------------------ 276

  Fly   308 SSRYVNSPHKEDVSAHHRSSHDHGYQGRYSGAGSSSHDTRKVKRLSP--ELDRYNHQPSTPPHKR 370
               .|:||...::        ::.|..:           ||....||  |..|.:.|.|..|:.|
Zfish   277 ---VVDSPSVAEL--------ENSYSSK-----------RKAASPSPYREPPRRSRQRSESPYGR 319

  Fly   371 RKFSDGREVGLGNFEHSRHHSGKYERYSRDRYSRRSSRSPSVQHSRSRQSPSGGLSSGSNAFRHG 435
            |:.|...:.|                            ||.|....|..||
Zfish   320 RRSSSPEKDG----------------------------SPYVSRKHSPGSP-------------- 342

  Fly   436 GSHKHKYGTTVSSTPSHTTRTSKRASGTGTSGDRYSRSPRTSSRYMESSPPSPVGASGSHHYHHR 500
                  |.:..|.:.|..:|||.||.         ||||..||....:|              |.
Zfish   343 ------YASRRSPSSSPVSRTSLRAR---------SRSPHYSSSRRSTS--------------HS 378

  Fly   501 RSPRMRQRTRGDSRRRSPSSASSESSASRSRSPTSRDLKHKREEYIKKISETSLFAELVKDRHKR 565
            ||.:....:.|      .|.|||.||...||||:|..|.          ..:||.|||.:.:.:|
Zfish   379 RSKKHSLYSGG------ASGASSHSSRPGSRSPSSSRLP----------ITSSLGAELTRRKQER 427

  Fly   566 QKALKEIIERQEENSNSNSNGALTIND----------------------NSSSVDGNTPNAADGR 608
            |.|..:.....:.|:::.:|..:...|                      .:.:|....|.|....
Zfish   428 QAAAAKNSPALQPNTSNVTNTPVKNTDPPPLETAAAAAAPPEPQRPPSPPAITVAVEEPAALPPP 492

  Fly   609 SAPGSGTPAAASTTSNGLQA-------LGSKPDLDLNN---IPMPNKQNDSVVSNPASNADVPDS 663
            ..|.|..|....|:...|.|       |.|.|.|.||:   .|.|.....::.|.|.|.|..|
Zfish   493 PLPLSSPPPLPLTSPPPLPASSPPPPPLSSPPPLPLNSPPPAPPPLAPAPALSSRPKSPAQKP-- 555

  Fly   664 VAQLKQPLLVPPFSASKNNIKPKSLTSLPLPPGMNVLDLAGARSPSPGQ--------KKESDEKN 720
               .|.|         .:.:|..:|..|||||.     |.|....||.:        :||.:::.
Zfish   556 ---AKSP---------AHQMKTSTLPPLPLPPA-----LLGDCRDSPKKSGLSQRLSRKEREKEK 603

  Fly   721 VTSSGSANKSVLNLPMPPVIPGSEELSGDDDVIDSPEDFDAPAVGTVHGHGGGPGTTRQRPVILN 785
            ........:.:..||:|||:.|     ||.....||.....|.:         ..:.::||.|.:
Zfish   604 EKEKEVRTRLLSELPLPPVLSG-----GDPSPPQSPARVSPPLL---------QPSFKKRPKICS 654

  Fly   786 RR--DSRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITA 848
            .|  :.:....|||:||||.|::|..||||||||||||:|..|.::||||||||::|||||||||
Zfish   655 PRYGERKQTQTDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITA 719

  Fly   849 VREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENN 913
            :||||||||||||::||:.|||||||||::|:||||:|||||||||||||||||||:|.|:.|:.
Zfish   720 IREIKILRQLNHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVSFSHEHV 784

  Fly   914 ASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLW 978
            .|.|:||::||:||||||||||||||||||:||.|::||||||||||||::: .|||||||||||
Zfish   785 QSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEE-SRPYTNKVITLW 848

  Fly   979 YRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIK 1043
            |||||||||||||.|:||||||||||||||.|:|:||||.|:.|||.||::||||.||.||:||:
Zfish   849 YRPPELLLGEERYSPAIDVWSCGCILGELFTKKPIFQANQELLQLELISRLCGSPCPAAWPDVIR 913

  Fly  1044 LPLFHTLKQKKTHRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPT 1108
            ||.|:|::.||.:||||||:|.|:|.|||||||.||.|||.:|.|||.||.|.:|..:.|::||.
Zfish   914 LPYFNTMRPKKQYRRRLREEFSFLPTPALDLLDHMLTLDPSRRCTAEQALASQFLCDVEPNKMPP 978

  Fly  1109 PQLPTWQDCHELWSKKRRRQMRE-QQESLP 1137
            |.||.|||||||||||||||.:. ..|.||
Zfish   979 PDLPHWQDCHELWSKKRRRQRQSGVSEDLP 1008

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	223/301 (74%)
		S_TKc	804..1098	CDD:214567	217/293 (74%)
cdk12	XP_003200579.2	STKc_CDK12	667..968	CDD:270847	223/301 (74%)
		S_TKc	675..968	CDD:214567	217/293 (74%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	465	1.000	Domainoid score	I451
eggNOG	1	0.900	-	-		E1_KOG0600
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D344403at33208
OrthoFinder	1	1.000	-	-		FOG0000444
OrthoInspector	1	1.000	-	-		oto40372
orthoMCL	1	0.900	-	-		OOG6_101677
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R186
SonicParanoid	1	1.000	-	-		X546
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.810