Protein Alignment Cdk12 and cdk12

DIOPT Version :9

• Sequence 1: NP_001262167.1
• Gene: Cdk12 / 40385
• FlyBaseID: FBgn0037093
• Length: 1157
• Species: Drosophila melanogaster
• Sequence 2: XP_012826946.1
• Gene: cdk12 / 100038049
• XenbaseID: XB-GENE-493308
• Length: 1466
• Species: Xenopus tropicalis
• Alignment Length: 1206
• Identity: 436/1206 - (36%)
• Similarity: 581/1206 - (48%)
• Gaps: 288/1206 - (23%)

  Fly    11 LVEYSDVSSED--FSD----QEAGDLDADAGKGAGNIKKPKPAPDNQF-SKGRLDAKPDKEGYDN 68
            ||||.|:||:.  |||    ||..:.|.         ::|....|... |:.|...|..||.
 Frog    63 LVEYDDISSDSDTFSDVPAKQERRENDE---------RRPSEKSDKMHKSRHRHQHKRLKEA--- 115

  Fly    69 YRSRRAEDSSDP---------VAAGSRQTSSSEATNPREEPSQASNTSKDELWGREIYMSSDSID 124
            .|:::.|....|         ....|:....|.|....:|..:...|||..        |.||
 Frog   116 TRTKQVEKERKPEKTQEVMVNKVPSSKDKIISSAKRTADEQEEHGRTSKSS--------SKDS-- 170

  Fly   125 TDELEAEMKRQKRKKQKKEKHKHKSKKKSKKRKKKRAKSYSSIDSMSDNDINALLDRRYTPPTAP 189
                .::|.:.|.:::::.|..||.:.|| .||:..:|.|.:.||                |...
 Frog   171 ----RSKMHKDKSRREREMKSGHKERSKS-HRKRDSSKRYKTSDS----------------PKRK 214

  Fly   190 SKSNERTVSAAPSSFTPHNLKESS-------SPATPPPVRRPNTNSNYYGESSLETANSALGSNL 247
            .:|..|....:|.....|:  |.|       ||:      |.:.:.|:         |.....|:
 Frog   215 GRSPRRKYGGSPKQDDSHS--EGSCGQDYDDSPS------RVHASGNF---------NETYRKNM 262

  Fly   248 QVTVTNKQSISNRLRSPPPSSRSSGNGPRFGNSPRTPPPSHYSSSGGGGVGSGSVVRDSRSSRYV 312
                                           :||....|:.|.||      :.|....||..|.|
 Frog   263 -------------------------------DSPSYKEPAAYQSS------ARSPSPYSRKQRSV 290

  Fly   313 NSPHKEDVSAHHRSSHDHGYQGRYSGAGSSSHDTRKVKRLSPELDRYNHQPSTPPHKRRKFSDGR 377
             ||::...|::.|.|      |.|||...|.:..|:..  ||.:.|.:...|..|.|..|
 Frog   291 -SPYRRRSSSYERGS------GSYSGRSPSPYVRRRSS--SPFVSRRSLSRSPAPRKSAK----- 341

  Fly   378 EVGLGNFEHSRHHSGKYERYSRDRYSRRSSRSPSVQHSRSRQSPSGGLSSGSNAFRHGGSHKHKY 442
                     ||..|..|.|.|..  |.||.:..|  .||||.|.........|
 Frog   342 ---------SRSRSPLYPRKSSS--SSRSKKQKS--QSRSRHSSISPARLPLN------------ 381

  Fly   443 GTTVSSTPSHTTRTSKRASGTGTSGDRYSRSPRTSSRYMESSPPSPVGASGSHHYHHRRSPRMRQ 507
                ||..:..:|..|..:....:..|.|:.                            ||.:.:
 Frog   382 ----SSLGAELSRKKKEIAAAAAAAGRESKG----------------------------SPLILK 414

  Fly   508 RTRGDSRRRSPSSASSESSASRSRSPTS------------RDLKHKREEYIKKISETSLFAELVK 560
            :..||||..|.......:...:...|.|            :.:..|:||..||....:...::..
 Frog   415 KESGDSRVASALDLKKATKVLKLEKPVSEPEMVTATSSETKTISAKKEESEKKPQVQAKDPKISG 479

  Fly   561 DRHKRQKALKEIIERQEENSNSNSNGALTINDNSSSVDGNTPNAADGRSAPGSGTPAAASTTSN- 624
            .:..:..|:||.:              ||..:..:..|.:.|......|.|   .|...|..||
 Frog   480 LKDCKPAAIKEEV--------------LTPKEGVTDRDKDVPPLPPILSPP---PPLPTSPPSNI 527

  Fly   625 -GLQALGSKPDL------------DLNNIPMPNKQNDSVVS---------NPASNADVP-DSVAQ 666
             .|..|...|.:            .|..:|:|.....|:.|         :..:|:.:| .|.|:
 Frog   528 PPLPPLPPSPAVLQQPPPPLPPPPTLTFLPLPTTVAASLTSSHYVRQSSLSTQANSQLPVPSPAK 592

  Fly   667 LKQPL--LVPPFSASKNNIKPKSLTSLPLPP---GMNVLDLAGARSPSPGQKKESDEKNVTSSGS 726
            .:.||  :||       ::|..:|..|||||   |.:.::......|....|||.|:..
 Frog   593 PQPPLIHMVP-------HMKTSTLPPLPLPPLLLGEDDIESPKEIPPPKSVKKEKDKDR------ 644

  Fly   727 ANKSVLNLPMPPVIPGSEELSGDDDVIDSPE-DFDAPAVGTVHGHGGGPGTTRQRPVILNRR--D 788
            ....:.:||:||.:||     ||....|||| ...||....:          ::||.|...|  :
 Frog   645 PRHLLTDLPLPPELPG-----GDPSPPDSPERKVVAPPQPPL----------KKRPKICCPRYGE 694

  Fly   789 SRNNVRDWGERCVDVFEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIK 853
            .:....|||:||||.|::|..||||||||||||:|..|.::||||||||::|||||||||:||||
 Frog   695 RKQTETDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIK 759

  Fly   854 ILRQLNHRNIVNLHEIVTDKQDAVEFRKDKGSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMK 918
            |||||.|:::||:.|||||||||::|:||||:|||||||||||||||||||:|.|:|::..|.||
 Frog   760 ILRQLIHKSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVQFSEDHIKSFMK 824

  Fly   919 QLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNADDRERPYTNKVITLWYRPPE 983
            ||::||.||||||||||||||||||:||.|::|||||||||||:::: .||||||||||||||||
 Frog   825 QLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSSEE-SRPYTNKVITLWYRPPE 888

  Fly   984 LLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAEMAQLETISKICGSPVPAVWPNVIKLPLFH 1048
            ||||||||.|:||||||||||||||.|:|:||||.|:||||.||::||||.|||||:|||||.|:
 Frog   889 LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRLCGSPCPAVWPDVIKLPYFN 953

  Fly  1049 TLKQKKTHRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPT 1113
            |:|.||.:||||||:|.|:|.|||||||.||.|||.||.|||..|:|.:|:.::..:|.||.||.
 Frog   954 TMKPKKQYRRRLREEFSFVPTPALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVDVCKMATPDLPH 1018

  Fly  1114 WQDCHELWSKKRRRQMREQQESL----PPTVIASTK 1145
            |||||||||||||||   :|..:    ||.:.|..|
 Frog  1019 WQDCHELWSKKRRRQ---RQSGIVLEEPPAIKAPRK 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk12	NP_001262167.1	STKc_CDK12	796..1098	CDD:270847	225/301 (75%)
		S_TKc	804..1098	CDD:214567	219/293 (75%)
cdk12	XP_012826946.1	STKc_CDK12	702..1003	CDD:270847	225/301 (75%)
		S_TKc	710..1003	CDD:214567	219/293 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	465	1.000	Domainoid score	I463
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	582	1.000	Inparanoid score	I996
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925637at2759
OrthoFinder	1	1.000	-	-		FOG0000444
OrthoInspector	1	1.000	-	-		otm48102
Panther	1	1.100	-	-	LDO	PTHR24056
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R186
SonicParanoid	1	1.000	-	-		X546
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.100