Protein Alignment SAK and CDC5

DIOPT Version :10

• Sequence 1: NP_649324.1
• Gene: SAK / 40384
• FlyBaseID: FBgn0026371
• Length: 769
• Species: Drosophila melanogaster
• Sequence 2: NP_013714.1
• Gene: CDC5 / 855013
• SGDID: S000004603
• Length: 705
• Species: Saccharomyces cerevisiae
• Alignment Length: 788
• Identity: 188/788 - (23%)
• Similarity: 302/788 - (38%)
• Gaps: 222/788 - (28%)

  Fly    12 EDYEVQHLLGKGGFATVYKARCLHTHQD----VAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHP 72
            :||...|.||:|||     |||.....|    .|.|.:.|..|:......::..|::||..:.||
Yeast    80 KDYHRGHFLGEGGF-----ARCFQIKDDSGEIFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHP 139

  Fly    73 SVLQLYTFFQDANYVYLVLELAHNGELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMHR 137
            :::|....|:|.:.||::||:..||.|...:.. .:..||.|......|:...:.|:||..::||
Yeast   140 NIVQFIDCFEDDSNVYILLEICPNGSLMELLKR-RKVLTEPEVRFFTTQICGAIKYMHSRRVIHR 203

  Fly   138 DISLSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVV--SRTSHGLPADVWSVG 200
            |:.|.|:......::||.|||||..|....||..|:|||||||:|||:  ..:.|....|:||:|
Yeast   204 DLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLG 268

  Fly   201 CMLYTLLVGRPPFETDAVQSTLNKVVMSEYIMPAH--LSYEAQDLINKLLKKLPHERITLEAVLC 263
            .|||.||:|:|||:...|.:...::...::..|..  :|.|.:.||..:|...|.||.:|..::.
Yeast   269 VMLYALLIGKPPFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIMD 333

  Fly   264 HPFMLKC------SNGGHSAPG--------ALNVFSQSMESGDSGIITFASSDSRNSQQ---IRS 311
            :.:....      |.....||.        :|..|...||.  |.::...|||....|:   |.|
Yeast   334 YVWFRGTFPPSIPSTVMSEAPNFEDIPEEQSLVNFKDCMEK--SLLLESMSSDKIQRQKRDYISS 396

  Fly   312 VENSGPQQVLPQIREEFKQVHHKLPYEQTGLFGQASTGLAEPNWPGAAKSSAFCMEAGNVPNSKQ 376
            :::|         .::.::.|...|:                                 :|:
Yeast   397 IKSS---------IDKLEEYHQNRPF---------------------------------LPH--- 416

  Fly   377 ASLKEDRISVPPLNTKRLLPTRYKTKNAIMSILRNGEVV-LEFLKFRPTYNEDRINDICRIS--D 438
                    |:.|..||:    :||            ||| :|        .:.|:||:.|.:  .
Yeast   417 --------SLSPGGTKQ----KYK------------EVVDIE--------AQRRLNDLAREARIR 449

  Fly   439 DGQRIIIYQPDPGRGLPVREQPPDLQIPSGDCVYNYDNLPSKHWKKYIYGARFVGLVKSKTPK-- 501
            ..|:.::.:........|.:....|:|.:.:|....:.:.... .:|..|    ||.||:.||
Yeast   450 RAQQAVLRKELIATSTNVIKSEISLRILASECHLTLNGIVEAE-AQYKMG----GLPKSRLPKIK 509

  Fly   502 --------VTYFSTLGKCQLMETMTDFEIRFYSGAKLLKTPSEG----LKVYDRNGMLLSDYSCS 554
                    |.|.:..|....:.| .|..:.|.:|..:|:.....    :...||.|.:.|.|..|
Yeast   510 HPMIVTKWVDYSNKHGFSYQLST-EDIGVLFNNGTTVLRLADAEEFWYISYDDREGWVASHYLLS 573

  Fly   555 ES-RSLIEHGNECFTHCVNISNALEVAQTKDNSCFPVTIGRRPITDVQPAQRLDGLRDTTNIAFS 618
            |. |.|..|              |||                                 .:....
Yeast   574 EKPRELSRH--------------LEV---------------------------------VDFFAK 591

  Fly   619 TPKSNQGSINFSLSTISSTRNTSDFGTNCSRSNMLAAHQ-NIPIKRINVPEIGIATELSHGVVQV 682
            ..|:|       ||.:|:      ||..       ..|: ::.::|....:..:..|||.|..|.
Yeast   592 YMKAN-------LSRVST------FGRE-------EYHKDDVFLRRYTRYKPFVMFELSDGTFQF 636

  Fly   683 QFYDGSVVSVIPSMQGGG--ITYTQPNGTSTHFGKGDDLPFPVRDRVGQIP-----NIQLKLKTA 740
            .|.|...:::    ..||  :||..|:..||.:...:.|.:      |:||     |.:.||
Yeast   637 NFKDHHKMAI----SDGGKLVTYISPSHESTTYPLVEVLKY------GEIPGYPESNFREKL--- 688

  Fly   741 PLLGSGRK 748
            .|:..|.|
Yeast   689 TLIKEGLK 696

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	89/262 (34%)
		POLO_box_Plk4_1	382..497	CDD:240557	23/117 (20%)
		POLO_box_Plk4_2	498..596	CDD:240558	23/112 (21%)
		POLO_box_Plk4_3	657..738	CDD:240559	21/88 (24%)
CDC5	NP_013714.1	STKc_PLK	80..337	CDD:271001	89/262 (34%)
		POLO_box_1	510..601	CDD:240561	25/145 (17%)
		POLO_box_2	613..698	CDD:240560	25/97 (26%)