Protein Alignment SAK and MASTL

DIOPT Version :10

• Sequence 1: NP_649324.1
• Gene: SAK / 40384
• FlyBaseID: FBgn0026371
• Length: 769
• Species: Drosophila melanogaster
• Sequence 2: NP_001307686.1
• Gene: MASTL / 84930
• HGNCID: 19042
• Length: 884
• Species: Homo sapiens
• Alignment Length: 801
• Identity: 180/801 - (22%)
• Similarity: 307/801 - (38%)
• Gaps: 188/801 - (23%)

  Fly    10 TIEDYEVQHLLGKGGFATVY---KARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKH 71
            :||::.:...:.:|.|..||   |...|:     |:|::.|..:....:|::|:.|.:..:..|.
Human    31 SIEEFSIVKPISRGAFGKVYLGQKGGKLY-----AVKVVKKADMINKNMTHQVQAERDALALSKS 90

  Fly    72 PSVLQLYTFFQDANYVYLVLELAHNGELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMH 136
            |.::.||...|.||.||||:|....|:: :.:.||...|.|..|...:.:|...|.|||.|.|:|
Human    91 PFIVHLYYSLQSANNVYLVMEYLIGGDV-KSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIH 154

  Fly   137 RDISLSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISP-EVVSRTSHGLPADVWSVG 200
            ||:...|:|:|.|.|:|:.||||:......|...|.:..||:...| :..|||    |..|.|
Human   155 RDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTPSMAKPRQDYSRT----PGQVLS-- 213

  Fly   201 CMLYTLLVGRPPFETDAVQSTLNKVVMSE-------YIMPAHLSYEAQDLI---NKLLKKLPHER 255
             ::.:|....|..|.:...:.:....:||       .:.|  :|.:.:|..   :||||.
Human   214 -LISSLGFNTPIAEKNQDPANILSACLSETSQLSQGLVCP--MSVDQKDTTPYSSKLLKS----- 270

  Fly   256 ITLEAVLCHPFM-LKCSNGGHSAPGALNVFSQSMESGDSGIITFASSDSRNSQQIRSVENSGPQQ 319
             .||.|..:|.| :||            :.|..::|...  :..:|:.|::...|.|||:
Human   271 -CLETVASNPGMPVKC------------LTSNLLQSRKR--LATSSASSQSHTFISSVES----- 315

  Fly   320 VLPQIREEFKQVHHKLPYEQTGLFGQASTGLAEPNWPGAAKSSAFCMEAGNVPNSKQASLKEDRI 384
                      :.|....:|:.......:.|....:|....|   .|.::.|...:|..:.|:..:
Human   316 ----------ECHSSPKWEKDCQESDEALGPTMMSWNAVEK---LCAKSANAIETKGFNKKDLEL 367

  Fly   385 SVPPLNTKRLLPTRYKTKNAIMSILR---NGEVVLEFLKFRPTYNEDRINDICRISDDGQRIIIY 446
            ::.|::....|||   |..:.:::.:   :|||..|.:       |..:|:| .:..|..::..:
Human   368 ALSPIHNSSALPT---TGRSCVNLAKKCFSGEVSWEAV-------ELDVNNI-NMDTDTSQLGFH 421

  Fly   447 QP-----DPG-------------RGLPVREQPPDLQIPSG--DCV-YNYDNLPSKHWKKYIYGAR 490
            |.     |.|             |...:.:..|..:|...  .|| |.::.:.:      .|..:
Human   422 QSNQWAVDSGGISEEHLGKRSLKRNFELVDSSPCKKIIQNKKTCVEYKHNEMTN------CYTNQ 480

  Fly   491 FVGL------VKSKTPKVTYFSTLGKCQLMETMTDFEIRFYSGAKLLKTPSE-GLKVYDRNGMLL 548
            ..||      :|....|........|..::.:.||.:          :||.: .:.:..:|.|..
Human   481 NTGLTVEVQDLKLSVHKSQQNDCANKENIVNSFTDKQ----------QTPEKLPIPMIAKNLMCE 535

  Fly   549 SDYSCSESRSLIEHGNECFTHCVNISNALEVAQTKDNSCFP-VTIGRRPITDVQPAQRLDGLRDT 612
            .|..| |..|..::.:..|. |.:...|.:......:|.|| ::|...|:    .:|.||..|..
Human   536 LDEDC-EKNSKRDYLSSSFL-CSDDDRASKNISMNSDSSFPGISIMESPL----ESQPLDSDRSI 594

  Fly   613 TNIAF------------------STPK---------SNQ---GSINFSLSTISSTRNTSDFGTNC 647
            ...:|                  ::||         |||   |.....|.|::|.||...|.:..
Human   595 KESSFEESNIEDPLIVTPDCQEKTSPKGVENPAVQESNQKMLGPPLEVLKTLASKRNAVAFRSFN 659

  Fly   648 SRSNMLAAHQNIPIKRINVPEIGIATELSHGVVQVQFYDGSVVSVI---------------PSMQ 697
            |..|   |..|....|:|:..:. |.::|..      |.||....|               |:..
Human   660 SHIN---ASNNSEPSRMNMTSLD-AMDISCA------YSGSYPMAITPTQKRRSCMPHQQTPNQI 714

  Fly   698 GGGITYTQPNGTSTHFGKGDD 718
            ..|..|..|..........||
Human   715 KSGTPYRTPKSVRRGVAPVDD 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	78/268 (29%)
		POLO_box_Plk4_1	382..497	CDD:240557	25/144 (17%)
		POLO_box_Plk4_2	498..596	CDD:240558	19/99 (19%)
		POLO_box_Plk4_3	657..738	CDD:240559	15/77 (19%)
MASTL	NP_001307686.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		STKc_MASTL	30..>223	CDD:270761	64/204 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	566..632		12/69 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	700..728		4/27 (15%)
		Protein Kinases, catalytic domain	<709..875	CDD:473864	6/27 (22%)