DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SAK and Plk3

DIOPT Version :9

Sequence 1:	NP_649324.1	Gene:	SAK / 40384	FlyBaseID:	FBgn0026371	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	NP_071523.1	Gene:	Plk3 / 58936	RGDID:	62039	Length:	647	Species:	Rattus norvegicus

Alignment Length:	417	Identity:	134/417 - (32%)
Similarity:	203/417 - (48%)	Gaps:	49/417 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLSNRAFGETIEDYEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEI 65
            ::::...|.|   |....||||||||..|:|....|....|:|:|.:..:.......::..|:|:
  Rat    52 LITDPRSGRT---YIKGRLLGKGGFARCYEATDTETSIAYAVKVIPQSRVAKPHQREKIINEIEL 113

  Fly    66 HSRLKHPSVLQLYTFFQDANYVYLVLELAHNGELHRYMNHI--AR-PFTETEAASILKQVVAGLL 127
            |..|:|..:::....|:||:.:|:.|||..    .:.:.||  || ...|.|....|:|:::||.
  Rat   114 HRDLQHRHIVRFSHHFEDADNIYIFLELCS----RKSLAHIWKARHTLLEPEVRYYLRQILSGLK 174

  Fly   128 YLHSHNIMHRDISLSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGL 192
            |||...|:|||:.|.|..::..|.:|:.|||||.:|:.|::|..|:||||||::|||:.|..||.
  Rat   175 YLHQRGILHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGP 239

  Fly   193 PADVWSVGCMLYTLLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERIT 257
            .|||||:||::||||.|.|||||..::.|...:....|.:||.||..|:.|:..:|:..|.:|.:
  Rat   240 EADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPS 304

  Fly   258 LEAVLCHPFMLK-----------CSNGGHSAP--GALNVFSQSMESGDSGIITFASSDSRNSQQI 309
            :|.:|.|.|..|           |.......|  .|.::|::..:|      .|....|:|....
  Rat   305 IEQILRHDFFTKGYTPDRLPVSSCVTVPDLTPPNPARSLFAKVTKS------LFGRRKSKNKNHS 363

  Fly   310 RSVEN-----SGPQQVL---PQIREEFKQVHHKLPYEQTGLFGQASTGLAEPNWP-GAAKSSAFC 365
            ...:|     ||..:..   |.:|.|........|   ..|...|    ||.:.| |...||...
  Rat   364 EEQDNVSCLVSGLMRTSIGHPDVRPEAPAASALAP---VSLVETA----AEDSSPRGTLASSGDG 421

  Fly   366 MEAG----NVPNSKQASLKEDRISVPP 388
            .|.|    .|..|...:|:.....:||
  Rat   422 FEEGLTVTTVVESALCALRNCVAFMPP 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	100/257 (39%)
		S_TKc	14..267	CDD:214567	100/255 (39%)
		POLO_box_Plk4_1	382..497	CDD:240557	2/7 (29%)
		POLO_box_Plk4_2	498..596	CDD:240558
		POLO_box_Plk4_3	657..738	CDD:240559
Plk3	NP_071523.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56		0/3 (0%)
		STKc_PLK3	60..314	CDD:271091	101/260 (39%)
		S_TKc	62..314	CDD:214567	100/255 (39%)
		POLO_box_1	461..549	CDD:240561
		POLO_box_2	562..629	CDD:240560
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0575
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507604at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820