Sequence 1: | NP_649324.1 | Gene: | SAK / 40384 | FlyBaseID: | FBgn0026371 | Length: | 769 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_005021.2 | Gene: | PLK1 / 5347 | HGNCID: | 9077 | Length: | 603 | Species: | Homo sapiens |
Alignment Length: | 585 | Identity: | 175/585 - (29%) |
---|---|---|---|
Similarity: | 268/585 - (45%) | Gaps: | 80/585 - (13%) |
- Green bases have known domain annotations that are detailed below.
Fly 20 LGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVLQLYTFFQDA 84
Fly 85 NYVYLVLELAHNG---ELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLLL 146
Fly 147 SREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYTLLVGRP 211
Fly 212 PFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKCSNGGHS 276
Fly 277 APGALNVFSQSMESGDSGIITFASSDSRNSQQIRSVENSGPQQVLPQ-IREEFKQVHHKLPYEQT 340
Fly 341 G--LFGQASTGLAEPNWPGAAKSSAFCMEAGNVPNSKQASLKEDRISVPPLNTKRLLPTRYKTKN 403
Fly 404 AIMSILRNGEVVLEFLKFRPTYNEDRINDICR--ISDDGQRIIIYQPDPGRG-LPVREQPPDLQI 465
Fly 466 PSGDCVYNYDNLPSKHWKKYIYGARFV---GLVKSKTPKV-TYFSTLGKCQLMETMTDFEIRFYS 526
Fly 527 G-AKLLKTPSEGLKVY-DRNG-------MLLSDYSCSESRSLIEHGNECFTHCVNISNALEVAQT 582
Fly 583 582 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
SAK | NP_649324.1 | STKc_PLK4 | 12..267 | CDD:271088 | 102/249 (41%) |
S_TKc | 14..267 | CDD:214567 | 102/249 (41%) | ||
POLO_box_Plk4_1 | 382..497 | CDD:240557 | 25/120 (21%) | ||
POLO_box_Plk4_2 | 498..596 | CDD:240558 | 20/95 (21%) | ||
POLO_box_Plk4_3 | 657..738 | CDD:240559 | |||
PLK1 | NP_005021.2 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..35 | ||
STKc_PLK1 | 45..309 | CDD:271089 | 103/257 (40%) | ||
Activation loop | 194..221 | 16/26 (62%) | |||
D-box that targets the protein for proteasomal degradation in anaphase | 337..340 | 0/2 (0%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 338..364 | 8/31 (26%) | |||
POLO_box_1 | 407..494 | CDD:240561 | 21/103 (20%) | ||
Linker | 493..507 | 3/13 (23%) | |||
POLO_box_2 | 509..590 | CDD:240560 | 20/93 (22%) | ||
Important for interaction with phosphorylated proteins. /evidence=ECO:0000250 | 538..540 | 0/1 (0%) | |||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_KOG0575 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D507604at2759 | |
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 1 | 1.000 | - | - | ||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
4 | 3.820 |