DRSC/TRiP Functional Genomics Resources

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Protein Alignment SAK and plk1

DIOPT Version :10

Sequence 1:NP_649324.1 Gene:SAK / 40384 FlyBaseID:FBgn0026371 Length:769 Species:Drosophila melanogaster
Sequence 2:NP_998844.1 Gene:plk1 / 407937 XenbaseID:XB-GENE-941540 Length:598 Species:Xenopus tropicalis


Alignment Length:622 Identity:173/622 - (27%)
Similarity:268/622 - (43%) Gaps:151/622 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 LGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVLQLYTFFQDA 84
            |||||||..|:...|.:.:..|.|::.|.::......:::..|:.|...|.|..|:..:.||:|.
 Frog    50 LGKGGFAKCYEITDLESREVFAGKIVPKTMLLKPHQKDKMTMEIAIQRSLDHRHVVGFHGFFEDN 114

  Fly    85 NYVYLVLELAHNG---ELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLLL 146
            ::||:||||....   |||:....:    ||.||...|||.:.|..||||:.::|||:.|.||.|
 Frog   115 DFVYVVLELCRRRSLLELHKRRKAV----TEPEARYYLKQTILGCQYLHSNRVIHRDLKLGNLFL 175

  Fly   147 SREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYTLLVGRP 211
            :.||.|||.||||||:::...||..|:|||||||:|||:.:..|....|:||:||::||||||:|
 Frog   176 NDEMEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLGKKGHSFEVDIWSIGCIMYTLLVGKP 240

  Fly   212 PFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKCSNGGHS 276
            ||||..::.|..::..:||.:|.|::..|..||.|:|:..|..|.|::.:|...|.    ..|: 
 Frog   241 PFETSCLKETYMRIKKNEYSVPKHINPMATALIQKMLRSEPTSRPTIDDLLNDEFF----TTGY- 300

  Fly   277 APGALNVFSQSMESGDSGIITFASSDSRNSQQIR---SVENSG------PQQVLPQIREEFKQVH 332
            .|..|.....::..      .|:.:.|...|.:|   :..|.|      .:|.:|...||.:|..
 Frog   301 IPSRLPTTCLTVPP------RFSIAPSTIDQSLRKPLTAINKGQDSPLVEKQSVPAKEEEMQQPE 359

  Fly   333 HKLPYEQTGLFGQASTGLAEPNWPGAAKSSAFCMEAGNVPNSKQASLK----EDRISVPPLNTKR 393
            ...|         |...|:|      ......|:.|  |..|::|.::    ||..|||.....:
 Frog   360 STEP---------ADCYLSE------MLQQLTCVNA--VKPSERAVIRQEEAEDPASVPIFWVSK 407

  Fly   394 LLPTRYKTKNAIMSILRNGEVVLEFLKFRPTYNEDRINDICRISDDGQRIIIYQPDPGRGLPVRE 458
            .:.  |..|..:...|.:..|.:.|                   :|..|:|:|  :.|..|...|
 Frog   408 WVD--YSDKYGLGYQLCDNSVGVLF-------------------NDSTRLIMY--NDGDSLQYIE 449

  Fly   459 QPPDLQIPSGDCVYNYDNLPSKHWKKYIYGARFVGLVKSKTPKVTYFSTLGKCQLMETMTDFEIR 523
            :      .:.:...|..:.|:...||       :.|:|       ||                 |
 Frog   450 R------NNSESYLNVRSYPAALTKK-------ITLLK-------YF-----------------R 477

  Fly   524 FYSGAKLLK-----TPSEG--------LKVYDR----------NGMLLSDYSCSESR-------- 557
            .|....|||     ||.||        |:.:.|          ||.:..::....::        
 Frog   478 NYMSEHLLKAGANITPREGDELARLPFLRTWFRTRSAIILHLSNGTVQINFFQDHTKIILCPLMA 542

  Fly   558 --SLIEHGNECFTH----------CVNISNALEVAQT 582
              |.|:...|..|:          |..:::.|..|:|
 Frog   543 AVSYIDEKREFHTYKLSLIQEFGCCKELASRLRYART 579

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SAKNP_649324.1 STKc_PLK4 12..267 CDD:271088 103/249 (41%)
POLO_box_Plk4_1 382..497 CDD:240557 21/114 (18%)
POLO_box_Plk4_2 498..596 CDD:240558 23/128 (18%)
POLO_box_Plk4_3 657..738 CDD:240559
plk1NP_998844.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
STKc_PLK1 36..300 CDD:271089 104/257 (40%)
Activation loop. /evidence=ECO:0000250 185..212 16/26 (62%)
D-box that targets the protein for proteasomal degradation in anaphase. /evidence=ECO:0000250 328..331 1/2 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 336..360 6/23 (26%)
POLO_box_1 401..488 CDD:240561 26/146 (18%)
Linker. /evidence=ECO:0000250 487..501 4/13 (31%)
POLO_box_2 503..584 CDD:240560 12/77 (16%)
Important for interaction with phosphorylated proteins. /evidence=ECO:0000250 532..534 0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

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