DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SAK and plk4

DIOPT Version :9

Sequence 1:	NP_649324.1	Gene:	SAK / 40384	FlyBaseID:	FBgn0026371	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	XP_005158928.1	Gene:	plk4 / 368390	ZFINID:	ZDB-GENE-030619-14	Length:	963	Species:	Danio rerio

Alignment Length:	950	Identity:	346/950 - (36%)
Similarity:	471/950 - (49%)	Gaps:	255/950 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IEDYEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVL 75
            |||::|..|||||.||.||:|:.::|..:|||||||||.:...|:..||..||||..||||||||
Zfish    31 IEDFKVLTLLGKGSFACVYRAKSVNTGLEVAIKMIDKKAMHKAGMVQRVINEVEIQCRLKHPSVL 95

  Fly    76 QLYTFFQDANYVYLVLELAHNGELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMHRDIS 140
            :||.:|:|:||||||||:.||||:.||:.....||||.||...:.|:|.|:||||:|.|||||::
Zfish    96 ELYNYFEDSNYVYLVLEMCHNGEMSRYLKERKNPFTEEEARHFMHQIVKGMLYLHTHGIMHRDLT 160

  Fly   141 LSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYT 205
            |:||||:..|::||||||||||||.|.|:|.|||||||||||||.:|::|||.:||||:|||.|.
Zfish   161 LTNLLLTTSMNIKIADFGLATQLKLPSEKHFTMCGTPNYISPEVATRSAHGLESDVWSLGCMFYA 225

  Fly   206 LLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKC 270
            .|.|||||:||.|:.||||||:.||.||.|:|.||||||.:||:|.|..|.:|.|||.||||.:
Zfish   226 FLTGRPPFDTDTVKRTLNKVVLGEYQMPMHISAEAQDLIQQLLQKNPALRPSLSAVLDHPFMTQ- 289

  Fly   271 SNGGHSAPGALNVFSQSMESG-------DSGIITFA--------SSDSR---------------- 304
                 |.|.|      |.:||       ||||.|.:        ||.||
Zfish   290 -----SGPTA------SKDSGSSDGGSIDSGIATISTASNATNNSSSSRLQRRTRQMIGQPLPSR 343

  Fly   305 ------------------------NSQQ-----------------------IRSVENS------- 315
                                    |||.                       :|...:|
Zfish   344 MAPIPSHSHHSTSSSFKSGQDWQPNSQDDLSRMGVGRIPVGADSGRPHSRYLRRAHSSDRSAVGY 408

  Fly   316 --GPQQV-LPQIREE---------FKQV------------HHKLP-------------------- 336
              .||:. |.:...|         |.|.            |.:||
Zfish   409 SHNPQEAELERCHSEEMLSGAGRLFPQTSGYRNAPHGYSKHDRLPSPPVKQPANPASSFSTSTHS 473

  Fly   337 -------------YEQTGLF-------GQASTG------------------------------LA 351
                         :...|:|       |.:|:|                              |.
Zfish   474 TRQQMPDSQTQPWFSNDGVFKRPADMSGHSSSGSFHSERGPIGTQTSCSDKPSGLHSQQQQPILF 538

  Fly   352 EPNWPGAAKSSAFCMEAGNVP----------------NSKQASLKEDRI----SVPPLNTKRLLP 396
            :.|.||..:..||.  :|::|                ..|..:.|:|::    |.|||...||.|
Zfish   539 QHNNPGPCREDAFV--SGHMPEPQAYSDAQFPCPPLSKGKANTEKKDKVCPKKSFPPLCAARLKP 601

  Fly   397 TRYKTKNAIMSILRNGEVVLEFLKFRPTYNEDRINDICRISDDGQRIIIYQPDPGRGLPVREQPP 461
            .|.|||||::|||.||||.:|.||.:..  ::|:.::.|||.||..:.:|||:.|:|.||.:.||
Zfish   602 IRQKTKNAVVSILGNGEVCMELLKGQGA--QERVKEVLRISCDGSMVTVYQPNEGKGFPVLDHPP 664

  Fly   462 DLQIPSGDCVYNYDNLPSKHWKKYIYGARFVGLVKSKTPKVTYFSTLGKCQLMETM--TDFEIRF 524
              ..|....:.::|:||.|:||||.|..:||.||||||||||.::...||.|||..  .|.|:.|
Zfish   665 --SPPEDILICSFDDLPEKYWKKYQYATKFVQLVKSKTPKVTLYTKFAKCMLMENSPNPDLEVCF 727

  Fly   525 YSGAKLLKTPSEGLKVYDRNG---MLLSDYSCS----ESRSLIEHGNECFTHCVNISNAL---EV 579
            |.|||..|| ||.::|.:::|   .:..|...|    |.|..||...|....|:::..|:   |.
Zfish   728 YDGAKTHKT-SEQVRVVEKSGKSYTVKGDVGLSGLNPECRLYIELSEEGHRMCLSLEAAITAEEQ 791

  Fly   580 AQTKDNSCFPVTIGRRPITDVQPAQ--------RLDGLRDTTNIAFSTPKSNQ---GSINFS--- 630
            ..:|:...||:||||||:..|.||.        |.....:..::..|.|:..|   ..|:::
Zfish   792 RSSKNTPFFPITIGRRPVNPVPPAPAPSSSSSCRPAAAAEVAHVCLSPPQHPQITPSMISYAGSD 856

  Fly   631 LSTISSTRNTSDFGTNCSRSNMLAAHQNIPIKRINVPEIGIATELSHGVVQVQFYDGSVVSVIPS 695
            |:|.|..:     |::..|.:....:....:|.|.||.||.|::|:.|.|.|||.|||.:.|
Zfish   857 LTTASVAK-----GSSPVRKDERTVNSGKVLKSIFVPNIGWASQLTTGEVWVQFNDGSQLMV--- 913

  Fly   696 MQGG--GITYTQPNGTSTHFGKGDDLPFPVRDRVGQIPNI 733
             |.|  .||:|.|.|..|.:.:.:.||..|::::..:.:|
Zfish   914 -QVGVSCITFTSPEGHITRYKENEKLPELVKEKLHCLSSI 952

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	159/254 (63%)
		S_TKc	14..267	CDD:214567	157/252 (62%)
		POLO_box_Plk4_1	382..497	CDD:240557	53/118 (45%)
		POLO_box_Plk4_2	498..596	CDD:240558	41/109 (38%)
		POLO_box_Plk4_3	657..738	CDD:240559	28/78 (36%)
plk4	XP_005158928.1	STKc_PLK4	32..287	CDD:271088	159/254 (63%)
		S_TKc	34..287	CDD:214567	157/252 (62%)
		POLO_box_Plk4_1	588..698	CDD:240557	52/113 (46%)
		POLO_box_Plk4_2	699..808	CDD:240558	41/109 (38%)
		POLO_box_Plk4_3	878..957	CDD:240559	28/78 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170582680
Domainoid	1	1.000	333	1.000	Domainoid score	I1113
eggNOG	1	0.900	-	-		E1_KOG0575
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7962
Inparanoid	1	1.050	548	1.000	Inparanoid score	I1114
OMA	1	1.010	-	-		QHG50064
OrthoDB	1	1.010	-	-		D342340at33208
OrthoFinder	1	1.000	-	-		FOG0007296
OrthoInspector	1	1.000	-	-		oto40065
orthoMCL	1	0.900	-	-		OOG6_106331
Panther	1	1.100	-	-	LDO	PTHR24345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9746
SonicParanoid	1	1.000	-	-		X5399
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800