Protein Alignment SAK and plk3

DIOPT Version :10

• Sequence 1: NP_649324.1
• Gene: SAK / 40384
• FlyBaseID: FBgn0026371
• Length: 769
• Species: Drosophila melanogaster
• Sequence 2: NP_958465.2
• Gene: plk3 / 334202
• ZFINID: ZDB-GENE-030131-6134
• Length: 660
• Species: Danio rerio
• Alignment Length: 628
• Identity: 167/628 - (26%)
• Similarity: 275/628 - (43%)
• Gaps: 106/628 - (16%)

  Fly    19 LLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVLQLYTFFQD 83
            ||||||||..|:...|..::..|:|:|.:..:.......::..|:|:|..|:|..|::....|:|
Zfish    64 LLGKGGFARCYEMTDLANNKMYAVKVIPQSRVSKPHQREKIINEIELHKSLQHKHVVKFSHHFED 128

  Fly    84 ANYVYLVLELAHNGELHRYMNHI--AR-PFTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLL 145
            .:.:|:.|||..    .:.:.||  || ..|:.|....|:|:::.|.|||:..|:|||:.|.|..
Zfish   129 QDNIYIFLELCS----RKSLAHIWKARHTLTDPEVRYYLRQIISSLKYLHNKGILHRDLKLGNFF 189

  Fly   146 LSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYTLLVGR 210
            ::..|.:::.|||||.:|:..::|..|:||||||::|||::|..||..:||||:||::||||.|.
Zfish   190 VNENMELRLGDFGLAAKLETVEQRKKTICGTPNYLAPEVLNRQGHGTESDVWSLGCVMYTLLCGN 254

  Fly   211 PPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKCSNGGH 275
            |||||..::.|...:...:|.:|:.|:..||.||:.:|:|.|.:|:||:.:|.|.:..|......
Zfish   255 PPFETLDLKETYKCIKEVKYSLPSSLTPSAQKLISSILQKNPCDRLTLDQILAHDYFTKGFTPEK 319

  Fly   276 SAPG-------------ALNVFSQSMESGDSGIITFASSDSRNSQQIRSVENSGPQQVLP-QIRE 326
            ..|.             |...|::..:|      .|....|:..::..|.|.....:::. .::.
Zfish   320 LPPSSCVMVPELNPPSPAKKFFTKMAKS------LFGKKKSKTVEKTTSEEKDDISKLVSGMVKH 378

  Fly   327 EF-KQVHHKL--------PYEQTGLFGQASTGLAEPNWPGAAKS------------------SAF 364
            .. :|:.:|.        |..|....|...|...|.:...|::|                  ||.
Zfish   379 SIGRQMSYKTMGVNEATSPTVQLASSGPLDTPAEEESRKSASRSFKGTVASSTDGCDDIPTPSAV 443

  Fly   365 CMEAGNVPNSKQASLKEDRISVPPL-NTKRLL-PTR---YKTKNAIMSILRNGEVVLEFLKFRPT 424
            ...|..|.||..:|:.....:.|.| .||..: .|:   |..|......|.|..|.:.|
Zfish   444 AESAMKVLNSCLSSMPTASRNPPCLVKTKPFIWVTKWVDYSNKYGFGYQLSNQNVGVLF------ 502

  Fly   425 YNEDRINDICRISDDGQRIIIYQPDPGR--GLPVREQPPDLQIPSG--DCVYNY----------- 474
             ||.....:|    |.:|.:.|.....:  ..|....|..||....  |.:.||
Zfish   503 -NEGTHLSLC----DQRRTVHYCLTNNKHFSFPANALPEKLQSQKHIVDLMANYMEQNLMEGGDI 562

  Fly   475 ---DNLPSK-----HWKKYIYGARFVGLVKSKTPKVTYFSTLGKCQLME-TMTDFEIRFYSGAKL 530
               |...|.     .|.|..:.  .|.|..::|.:|.:::...|..|.: :...:.:.|.|..::
Zfish   563 NCEDQSSSSSPLLLQWIKTDHA--LVMLFDNRTLQVNFYTDHTKIILCKPSDASYLVTFISKERV 625

  Fly   531 LKTPSEGLKVYDRNGMLLSDYSCS-ESRSLIEHGNECFTHCVN 572
            ..:       |..|  :||:..|| |.|..:.:..:...|..|
Zfish   626 SYS-------YPLN--VLSELGCSPELRQRLHYVVQLLQHYTN 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	96/250 (38%)
		POLO_box_Plk4_1	382..497	CDD:240557	30/142 (21%)
		POLO_box_Plk4_2	498..596	CDD:240558	16/77 (21%)
		POLO_box_Plk4_3	657..738	CDD:240559
plk3	NP_958465.2	STKc_PLK3	57..311	CDD:271091	96/250 (38%)
		POLO_box_1	473..561	CDD:240561	20/98 (20%)
		POLO_box_2	573..656	CDD:240560	18/93 (19%)