DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SAK and plk1

DIOPT Version :9

Sequence 1:	NP_649324.1	Gene:	SAK / 40384	FlyBaseID:	FBgn0026371	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	NP_001003890.3	Gene:	plk1 / 280649	ZFINID:	ZDB-GENE-021115-7	Length:	595	Species:	Danio rerio

Alignment Length:	516	Identity:	141/516 - (27%)
Similarity:	229/516 - (44%)	Gaps:	128/516 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TIEDYEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSV 74
            |::.|.....|||||||..|:...:.|.:..|.|::.|.::.......::..|:.||..|.:|.|
Zfish    35 TMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKPHQKEKMSTEIAIHKSLDNPHV 99

  Fly    75 LQLYTFFQDANYVYLVLELAHNG---ELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMH 136
            :..:.||:|.::||:|||:....   |||:....:    ||.||...::|.:.|:.|||::.::|
Zfish   100 VGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAV----TEPEARYFMRQTIQGVQYLHNNRVIH 160

  Fly   137 RDISLSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGC 201
            ||:.|.||.|:.:|.|||.||||||:::...||..|:|||||||:|||:.:..|....|:||:||
Zfish   161 RDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKTLCGTPNYIAPEVLCKKGHSFEVDIWSLGC 225

  Fly   202 MLYTLLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPF 266
            :|||||||:|||||..::.|..::..:||.:|.|::..|..||.::|...|..|.::..:|...|
Zfish   226 ILYTLLVGKPPFETSCLKETYIRIKKNEYSVPRHINPVASALIRRMLHADPTLRPSVAELLTDEF 290

  Fly   267 MLKCSNGGHS-----------------APGALN------VFSQSMESGDSGIITFASSDSRNSQQ 308
            .    ..|::                 ||.:|:      ..|...:..||.|......|....:.
Zfish   291 F----TSGYAPMRLPTSCLTVPPRFSIAPSSLDPALLRKPLSSLNKGTDSPIEEMGKMDQPQRED 351

  Fly   309 IRSVENSGPQQ-------VLPQ--------------IREEFKQ---------------------V 331
            ::  :..||:|       :|.|              ||:|..:                     :
Zfish   352 LQ--QRDGPEQPDTHLTDMLQQLAVVNAAKPSDRDFIRQEEAEDPACIPVFWISKWVDYSDKYGL 414

  Fly   332 HHKLPYEQTGLFGQASTGLAEPNWPGAAKSSAFCMEAGNVPNSKQASLKEDRISV---PPLNTKR 393
            .::|.....|:....||.|            ..|.:..::....:.|| |..:||   |...:|:
Zfish   415 GYQLSDNSVGVLFNDSTRL------------IMCADGDSLQYIDRNSL-ESYLSVRSYPSALSKK 466

  Fly   394 LLPTRY----------------------------------KTKNAIMSILRNGEVVLEFLK 420
            :...:|                                  :||:||:..|.||.|.:.|.:
Zfish   467 ITLLKYFRNYMSEHLLKAGANITPREGDELTRLPYLRHWFRTKSAIVLHLSNGTVQINFFQ 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	99/257 (39%)
		S_TKc	14..267	CDD:214567	99/255 (39%)
		POLO_box_Plk4_1	382..497	CDD:240557	14/76 (18%)
		POLO_box_Plk4_2	498..596	CDD:240558
		POLO_box_Plk4_3	657..738	CDD:240559
plk1	NP_001003890.3	STKc_PLK1	31..295	CDD:271089	101/267 (38%)
		S_TKc	39..291	CDD:214567	99/255 (39%)
		POLO_box_1	398..485	CDD:240561	14/99 (14%)
		POLO_box_2	500..581	CDD:240560	9/28 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0575
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507604at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820