Protein Alignment SAK and Plk5

DIOPT Version :10

• Sequence 1: NP_649324.1
• Gene: SAK / 40384
• FlyBaseID: FBgn0026371
• Length: 769
• Species: Drosophila melanogaster
• Sequence 2: NP_001420485.1
• Gene: Plk5 / 216166
• MGIID: 3026984
• Length: 608
• Species: Mus musculus
• Alignment Length: 541
• Identity: 143/541 - (26%)
• Similarity: 211/541 - (39%)
• Gaps: 168/541 - (31%)

  Fly    14 YEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTG---LTNRVRQEVEIHSRLKHPSVL 75
            |....|:|||.|:..||...:.|....|:|::.:   .|.|   |..:|.:|:.:||||:|.:::
Mouse    27 YRRGKLIGKGAFSRCYKLTDMSTSAVFALKVVPR---GGAGRLRLRGKVEREIALHSRLRHRNIV 88

  Fly    76 QLYTFFQDANYVYLVLELAHNGELHRYMN-------------HIARPFTETEAASILKQVVAGLL 127
            ..:..|.|.::||:|||.. :.::|...|             .:.|..||.|....|:.:|:||.
Mouse    89 AFHAHFADRDHVYMVLEYC-SRQIHNPSNKYQVPLQSLAHVLKVRRTLTEPEVRYYLRGLVSGLR 152

  Fly   128 YLHSHNIMHRDISLSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGL 192
            |||...|:|||:..||..|::.|.|||.|.|||.::......|..:|||||:.:||||||..|..
Mouse   153 YLHQQRIVHRDLKPSNFFLNKNMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSRNGHSC 217

  Fly   193 PADVWSVGCMLYTLLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERIT 257
            .:|:|::||::||:|.|.|||....:......:....|:.|.|||..|:.||.:||...|.||.:
Mouse   218 KSDIWALGCIMYTVLTGTPPFAAAPLSEMYQNIRDGHYLEPTHLSPSARSLIARLLAPDPAERPS 282

  Fly   258 LEAVL------------------CH------------------------------PFMLKCSNGG 274
            |:.:|                  ||                              ||..|.::|
Mouse   283 LDHLLQDDFFSQGFTPERLPPHSCHSPPVFAFPPPLGRLFRKVGQLLLTQCRPPCPFTSKEASG- 346

  Fly   275 HSAPGALNVFSQSMESGDSGIITFASSDSRNSQQIRSVENSGPQQVLPQIREEFKQVHHKLPYEQ 339
               ||........||:|:                    |...|.....:|        |.|
Mouse   347 ---PGEEGTEPDHMEAGN--------------------EERDPLCTEGRI--------HLL---- 376

  Fly   340 TGLFGQASTGLAEPNWPG--------AAKSSAFCMEAGNVPNSKQASLKEDRISVPPLNTKRLLP 396
              ..|...||||.|.  |        |.:....|::||  |.:.|....|.|            |
Mouse   377 --TLGTPRTGLAGPK--GSLALQLEVATRKLFLCLDAG--PMAGQDPPGEQR------------P 423

  Fly   397 TRYKTKNAIMSILRNGEVVLEFLKFRPTYNEDRINDICRISDDGQRIII---------------- 445
            ..:..|....|           ||:...|         ::||.|..::.
Mouse   424 VLWAPKWVDYS-----------LKYGFGY---------QLSDGGSGVLFRDGSHMALRPQGGHVS 468

  Fly   446 YQPDPGR--GLPVREQPPDLQ 464
            ||||.|.  ...:|:.|..|:
Mouse   469 YQPDQGTLWTFTLRDVPSPLR 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	98/316 (31%)
		POLO_box_Plk4_1	382..497	CDD:240557	18/101 (18%)
		POLO_box_Plk4_2	498..596	CDD:240558
		POLO_box_Plk4_3	657..738	CDD:240559
Plk5	NP_001420485.1	STKc_PLK	25..292	CDD:271001	95/268 (35%)
		POLO_box_1	423..510	CDD:240561	17/87 (20%)