Protein Alignment SAK and Plk4

DIOPT Version :10

• Sequence 1: NP_649324.1
• Gene: SAK / 40384
• FlyBaseID: FBgn0026371
• Length: 769
• Species: Drosophila melanogaster
• Sequence 2: NP_001397550.1
• Gene: Plk4 / 20873
• MGIID: 101783
• Length: 926
• Species: Mus musculus
• Alignment Length: 931
• Identity: 323/931 - (34%)
• Similarity: 472/931 - (50%)
• Gaps: 230/931 - (24%)

  Fly    11 IEDYEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVL 75
            |||::|.:|||||.||.||:|..:||..:|||||||||.:...|:..||:.||:||.:|||||||
Mouse    10 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSVL 74

  Fly    76 QLYTFFQDANYVYLVLELAHNGELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMHRDIS 140
            :||.:|:|.||||||||:.||||::||:.:..:||:|.||...:.|::.|:||||||.|:|||::
Mouse    75 ELYNYFEDNNYVYLVLEMCHNGEMNRYLKNRMKPFSEREARHFMHQIITGMLYLHSHGILHRDLT 139

  Fly   141 LSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYT 205
            |||:||:|.|::|||||||||||..|.|:|.|:||||||||||:.:|::|||.:|:||:|||.||
Mouse   140 LSNILLTRNMNIKIADFGLATQLNMPHEKHYTLCGTPNYISPEIATRSAHGLESDIWSLGCMFYT 204

  Fly   206 LLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFM--- 267
            ||:|||||:||.|::||||||:::|.|||.||.||||||::||::.|.:|::|.:||.||||
Mouse   205 LLIGRPPFDTDTVKNTLNKVVLADYEMPAFLSREAQDLIHQLLRRNPADRLSLSSVLDHPFMSRN 269

  Fly   268 -------------------------LKCSNG--------------GHSAPGALNVFSQSMESGDS 293
                                     :..|:|              |...|..:.||.::..|.|
Mouse   270 PSPKSKDVGTVEDSMDSGHATLSTTITASSGTSLSGSLLDRRLLVGQPLPNKITVFQKNKNSSD- 333

  Fly   294 GIITFASSDSRN--------------------------------------------SQQIR---- 310
                |:|.|..|                                            |.|.|
Mouse   334 ----FSSGDGSNFCTQWGNPEQEANSRGRGRVIEDAEERPHSRYLRRAHSSDRASPSNQSRAKTY 394

  Fly   311 SVENSGPQQVLPQIREEFKQVHH--------KLPY---EQT-------GLFG--QASTGLAEPN- 354
            |||.....::|.:.|....:..|        |.|:   :||       ..||  |.:..|.|.|
Mouse   395 SVERCHSVEMLSKPRRSLDENQHSSNHHCLGKTPFPFADQTPQMEMVQQWFGNLQMNAHLGETNE 459

  Fly   355 -----------------------WPGAA----------------------------KSSAFCMEA 368
                                   |....                            |......|.
Mouse   460 HHTVSPNRDFQDYPDLQDTLRNAWTDTRASKNADTSANVHAVKQLSAMKYMSAHHHKPEVMPQEP 524

  Fly   369 GNVPNSKQA---SLKED--------RISVPPLNTKRLLPTRYKTKNAIMSILRNGEVVLEFLKFR 422
            |..|:|:|:   |::..        |....||...||.|.|.|||.|::|||.:.||.:|.|  |
Mouse   525 GLHPHSEQSKNRSMESTLGYQKPTLRSITSPLIAHRLKPIRQKTKKAVVSILDSEEVCVELL--R 587

  Fly   423 PTYNEDRINDICRISDDGQRIIIYQPDPGRGLPVREQPPDLQIPSGDCV-YNYDNLPSKHWKKYI 486
            ...:|..:.::.:||.||..|.:|.|:.|||.|:.::||   :|:.:.. |::||||.|:|:||.
Mouse   588 ECASEGYVKEVLQISSDGTMITVYYPNDGRGFPLADRPP---LPTDNISRYSFDNLPEKYWRKYQ 649

  Fly   487 YGARFVGLVKSKTPKVTYFSTLGKCQLMETM--TDFEIRFYSGAKLLKTPSEGLKVYDRNGMLLS 549
            |.:||:.||:|||||:|||:...||.|||..  .|||:.||.|||:.||.:. :.:.::.|:..:
Mouse   650 YASRFIQLVRSKTPKITYFTRYAKCILMENSPGADFEVWFYDGAKIHKTENL-IHIIEKTGISYN 713

  Fly   550 DYSCSESRSL-------IEHGNECFTHCVNISNAL--EVAQTKDNSCFPVTIGRRPITDVQP--- 602
            ..:.:|..||       ::|.||....|:::.:.:  |..:::.:|.||:.:||:|.....|
Mouse   714 LKNENEVTSLKEEVKVYMDHANEGHRICLSLESVISEEEKRSRGSSFFPIIVGRKPGNTSSPKAL 778

  Fly   603 ----------------AQRLDGLRDTTNIAFSTPKSNQGSINFSLSTISSTRNTSDFGTNCSRSN 651
                            |.||    ...:.||.|..........::..:..|...:  ||..|.|.
Mouse   779 SAPPVDPSCCKGEQASASRL----SVNSAAFPTQSPGLSPSTVTVEGLGHTATAT--GTGVSSSL 837

  Fly   652 MLAAHQNIPIKRINVPEIGIATELSHGVVQVQFYDGSVVSVIPSMQGG--GITYTQPNGTSTHFG 714
            ..:|..   :|.:.|..:|.||:|:.|.|.|||.|||.:.|    |.|  .|:||.|:|.:|.:|
Mouse   838 PKSAQL---LKSVFVKNVGWATQLTSGAVWVQFNDGSQLVV----QAGVSSISYTSPDGQTTRYG 895

  Fly   715 KGDDLPFPVRDRVGQIPNIQL 735
            :.:.||..::.::..:.:|.|
Mouse   896 ENEKLPEYIKQKLQCLSSILL 916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	154/254 (61%)
		POLO_box_Plk4_1	382..497	CDD:240557	48/123 (39%)
		POLO_box_Plk4_2	498..596	CDD:240558	36/108 (33%)
		POLO_box_Plk4_3	657..738	CDD:240559	28/81 (35%)
Plk4	NP_001397550.1	STKc_PLK4	11..266	CDD:271088	154/254 (61%)
		Plk4_PB1	553..659	CDD:465672	46/110 (42%)
		POLO_box_Plk4_2	661..769	CDD:240558	36/108 (33%)
		POLO_box_Plk4_3	840..919	CDD:240559	29/84 (35%)