Protein Alignment SAK and plk-1

DIOPT Version :10

• Sequence 1: NP_649324.1
• Gene: SAK / 40384
• FlyBaseID: FBgn0026371
• Length: 769
• Species: Drosophila melanogaster
• Sequence 2: NP_001021173.1
• Gene: plk-1 / 176143
• WormBaseID: WBGene00004042
• Length: 648
• Species: Caenorhabditis elegans
• Alignment Length: 547
• Identity: 156/547 - (28%)
• Similarity: 238/547 - (43%)
• Gaps: 130/547 - (23%)

  Fly    14 YEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVLQLY 78
            ||....|||||||..|:.....|.:.||.|::.|.::......:::.|||:||..|.|.::::|:
 Worm    38 YEKGRFLGKGGFAHCYELTNRATREVVAGKVVPKSMLVKQYQRDKMTQEVQIHRELGHINIVKLF 102

  Fly    79 TFFQDANYVYLVLELAHNG---ELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMHRDIS 140
            .||:|...||:.|||....   |||:....:    ||.||.....|:|.|:||||..||:|||:.
 Worm   103 NFFEDNLNVYITLELCARRSLMELHKRRKAV----TEPEARYFTHQIVDGVLYLHDLNIIHRDMK 163

  Fly   141 LSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYT 205
            |.||.|:.::.|||.||||||.: ..|||..|:|||||||:|||:::..|....|:|:|||:||.
 Worm   164 LGNLFLNDDLVVKIGDFGLATTV-NGDERKKTLCGTPNYIAPEVLNKAGHSFEVDIWAVGCILYI 227

  Fly   206 LLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFM--- 267
            ||.|:||||:.:::.|.:::..:.|.:|:..:..|..||.|:|...|..|.|.:.|....|.
 Worm   228 LLFGQPPFESKSLEETYSRIRHNNYTIPSIATQPAASLIRKMLDPEPTRRPTAKQVQRDGFFKSG 292

  Fly   268 -------LKCSN-----GGHS--------APGALNVFSQSMESGDSGI------ITFASSDSRNS 306
                   :.|..     |||.        ||..::..||...:|.:|:      |...::|...:
 Worm   293 FMPTRLPVSCLTMVPKFGGHETSMMEENVAPRGVDARSQRPLNGRAGLSALPQHIVSNNADRERA 357

  Fly   307 QQ------IRSVENSGPQQVLPQIREEFKQVHHKLPYEQTGLFGQASTGLAEPNW---------- 355
            ||      .|..|::...|:..|:....:|....|..|:..|.|..|.......|
 Worm   358 QQQAAEATFREPEDAYLSQLFHQVAVLLEQRIPGLEEEEAALDGYQSPECLPVFWISKWVDYSDK 422

  Fly   356 ----------------------------------PGAAKSSAFCMEAGNVP---NSKQASLK--- 380
                                              ..:.|...|.|.:|.:|   |.|...||
 Worm   423 YGIGYQLCDNSVGVLFNDNSRIMLDQAGNELTYIEKSNKEHYFSMHSGEMPGLLNKKVTLLKYFR 487

  Fly   381 -------------------EDRISVPPLNTKRLLPTRYKTKNAIMSILRNGEVVLEFLKFRPTYN 426
                               :|...:|.|.      ..::||:||:..|.||.|.:.|      :|
 Worm   488 SYMNDHLVKAGEGSEQRAGDDLARLPTLR------VWFRTKSAIVLHLSNGTVQINF------FN 540

  Fly   427 EDRINDICRIS------DDGQRIIIYQ 447
            :.....:|.:.      |..:|::.|:
 Worm   541 DHVKMMMCPLMQAVTFIDQNKRMLTYK 567

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	104/255 (41%)
		POLO_box_Plk4_1	382..497	CDD:240557	17/72 (24%)
		POLO_box_Plk4_2	498..596	CDD:240558
		POLO_box_Plk4_3	657..738	CDD:240559
plk-1	NP_001021173.1	STKc_PLK	36..289	CDD:271001	104/255 (41%)
		POLO_box_1	409..499	CDD:240561	10/89 (11%)
		POLO_box_2	513..594	CDD:240560	16/67 (24%)