Protein Alignment SAK and plk-2

DIOPT Version :10

• Sequence 1: NP_649324.1
• Gene: SAK / 40384
• FlyBaseID: FBgn0026371
• Length: 769
• Species: Drosophila melanogaster
• Sequence 2: NP_491036.1
• Gene: plk-2 / 171838
• WormBaseID: WBGene00004043
• Length: 632
• Species: Caenorhabditis elegans
• Alignment Length: 662
• Identity: 187/662 - (28%)
• Similarity: 281/662 - (42%)
• Gaps: 132/662 - (19%)

  Fly     8 GETIEDYEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHP 72
            ||....||....|||||||..|:.|...|.:..|.|::.|.|:......:::.|||:||..|:|.
 Worm    30 GERKTRYEKGKFLGKGGFAHCYELRNKSTGELFAGKVVPKALLIKQYQRDKMAQEVQIHRNLQHR 94

  Fly    73 SVLQLYTFFQDANYVYLVLELAHNG---ELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNI 134
            :|::||.||:|.:.||:.|||....   |||:....:    ||.||.....|:|.|:||||:..|
 Worm    95 NVVKLYHFFEDKSNVYITLELCPRRSLMELHKRRKAV----TEPEARYFTYQIVEGVLYLHNLKI 155

  Fly   135 MHRDISLSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSV 199
            :|||:.|.||.|:.|:.|||.||||||.... |||..|:|||||||:|||:::..|....|:|::
 Worm   156 VHRDLKLGNLFLNDELQVKIGDFGLATTCDN-DERKKTLCGTPNYIAPEVLNKIGHSFEVDLWAI 219

  Fly   200 GCMLYTLLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCH 264
            ||:||.||.|.||||:.:::.|.:::..:.|::|...|..|..||..||..:|..|....|| |.
 Worm   220 GCILYILLFGHPPFESKSLEETYSRIKNNNYVIPTSASAAASQLIRVLLDPVPSRRPNARAV-CR 283

  Fly   265 PFMLKCSNGGHSAPGALNVFSQSM-------ESGDSGIITFASSDSRNSQQI-RSVENSGPQQVL 321
            ....|..    ..|..|.|...:|       |..:..:....:.|.|...|. ||..::.|..::
 Worm   284 DHFFKSG----FMPARLPVSCLTMVPHLNDDEYAEENVSPSGTIDQRGPHQAGRSGLSAIPAHLV 344

  Fly   322 PQIREEFKQVHHKLPYEQ------TGLFGQASTGLAEPNWPGAAKSSAFCMEAGNVPNSKQASLK 380
            .: ..|.:|.|....|.|      :.|..|.:..||.|.                      |.:.
 Worm   345 SR-NSERQQTHRMEAYRQPTDCYLSNLLAQVNDLLATPT----------------------ADID 386

  Fly   381 EDRISVPPLNTKRLLP-------TRYKTKNAIMSILRNGEVVLEFLKFRPTYNEDRINDICRISD 438
            :...::....:...||       ..|..|..|...|.:..|.:.|            ||..||..
 Worm   387 DAEAALDSYQSPEALPVFWISKWVDYSDKYGIGYQLCDNSVGVLF------------NDNSRIML 439

  Fly   439 D--GQRIIIYQPDPGRGLPVREQPPDLQ--IPSGDCVYNYDNLPS-----KHWKKYIYG------ 488
            |  |.::...:...      :|...|::  ||||        |..     |:::.|:..
 Worm   440 DTAGTQLTYIEKTE------KEHYFDMESAIPSG--------LQKKMTLLKYFRSYMNDHLLQAG 490

  Fly   489 ---ARFVG--LVKSKTPKVTYFSTLGKCQLMETMTDFEIRFYSG-AKLLKTP-SEGLKVYDRNGM 546
               .|.||  |.:..|.:| :|.|.....|..:....:|.|::. .|::..| .:.:...|.|..
 Worm   491 QQVTRKVGDDLARLPTLRV-WFRTKSAIVLHLSNGTVQINFFNDHIKMVLCPLMQAVTFIDENKR 554

  Fly   547 L-------LSDYSCSE-------------SRSLIEHGNECFTHCVNISNALEVAQTKDNSCFPVT 591
            :       |::..|.|             .|.:.||..|...|....:||:.:..|..|
 Worm   555 MFTYKFSHLAENGCPEKFLHRIQYAKCMIQRLVEEHTKEETKHNAPAANAVRLPSTSSN------ 613

  Fly   592 IGRRPITDVQPA 603
            :......|:|||
 Worm   614 VRLESAADIQPA 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	108/257 (42%)
		POLO_box_Plk4_1	382..497	CDD:240557	27/141 (19%)
		POLO_box_Plk4_2	498..596	CDD:240558	23/119 (19%)
		POLO_box_Plk4_3	657..738	CDD:240559
plk-2	NP_491036.1	STKc_PLK	34..287	CDD:271001	108/258 (42%)
		POLO_box_1	402..490	CDD:240561	22/113 (19%)
		POLO_box_2	505..586	CDD:240560	14/81 (17%)