Protein Alignment SAK and PLK2

DIOPT Version :9

• Sequence 1: NP_649324.1
• Gene: SAK / 40384
• FlyBaseID: FBgn0026371
• Length: 769
• Species: Drosophila melanogaster
• Sequence 2: NP_006613.2
• Gene: PLK2 / 10769
• HGNCID: 19699
• Length: 685
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 150/585 - (25%)
• Similarity: 248/585 - (42%)
• Gaps: 169/585 - (28%)

  Fly    19 LLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVLQLYTFFQD 83
            :|||||||..|:...|..::..|.|:|....:.......::.:|:|:|..|.|..|:|.|.:|:|
Human    87 VLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFED 151

  Fly    84 ANYVYLVLELAHNGELHRYMNHIARP---FTETEAASILKQVVAGLLYLHSHNIMHRDISLSNLL 145
            ...:|::||...    .|.|.||.:.   .||.|....|:|:|:||.|||...|:|||:.|.|..
Human   152 KENIYILLEYCS----RRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFF 212

  Fly   146 LSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYTLLVGR 210
            ::..|.:|:.|||||.:|:..:.|..|:||||||:||||:::..||..:|:|::||::||:|:||
Human   213 INEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGR 277

  Fly   211 PPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLK------ 269
            |||||..::.|...:..:.|.||:.|...|:.||..:|.|.|.:|.:|:.::.|.|.|:
Human   278 PPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDR 342

  Fly   270 -CSNGGHSAPG------ALNVFSQ---SMESGDSGIITFASSDSRNSQQIRSVENSGPQQVLPQI 324
             .|:..|:.|.      |.|.|.:   ::..|......:..:.:|.|::
Human   343 LSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYIDTHNRVSKE---------------- 391

  Fly   325 REEFKQVHHKLPYEQTGLFGQASTGLAEPNWPGAAKSSAFCMEAGNVPNSKQASLKEDRISVPPL 389
            .|:..::.|.|                                       |:.|:.:.
Human   392 DEDIYKLRHDL---------------------------------------KKTSITQQ------- 410

  Fly   390 NTKRLLPTRYKTKNAIM----SILRNGEVVLEFLKFRPTYNEDRINDICR--------------- 435
                  |::::|...:.    ::.|:|...:|        |:.:|.|..|
Human   411 ------PSKHRTDEELQPPTTTVARSGTPAVE--------NKQQIGDAIRMIVRGTLGSCSSSSE 461

  Fly   436 ---------ISDDGQRIIIYQPDPGRGLPVREQPPDLQ-IPSGDCVYNYDNLPSKHW-------- 482
                     ::|...|::       ||.        |: :|..||:.......|..|
Human   462 CLEDSTMGSVADTVARVL-------RGC--------LENMPEADCIPKEQLSTSFQWVTKWVDYS 511

  Fly   483 KKYIYGARF----VG-----------LVKSKTPKVTYFSTLGKCQLMETMTDFEIRFYSGAKLLK 532
            .||.:|.:.    ||           |...||  |.|::.||:|.:... ||...:|.|...:||
Human   512 NKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKT--VHYYAELGQCSVFPA-TDAPEQFISQVTVLK 573

  Fly   533  532
            Human   574  573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	96/250 (38%)
		S_TKc	14..267	CDD:214567	96/250 (38%)
		POLO_box_Plk4_1	382..497	CDD:240557	25/166 (15%)
		POLO_box_Plk4_2	498..596	CDD:240558	13/35 (37%)
		POLO_box_Plk4_3	657..738	CDD:240559
PLK2	NP_006613.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	21..70
		STKc_PLK2	80..334	CDD:271090	96/250 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	406..433		5/39 (13%)
		POLO_box_1	503..588	CDD:240561	20/74 (27%)
		POLO_box_2	601..682	CDD:240560

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0575
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507604at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820