DRSC/TRiP Functional Genomics Resources

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Protein Alignment SAK and PLK4

DIOPT Version :9

Sequence 1:NP_649324.1 Gene:SAK / 40384 FlyBaseID:FBgn0026371 Length:769 Species:Drosophila melanogaster
Sequence 2:XP_016863151.1 Gene:PLK4 / 10733 HGNCID:11397 Length:971 Species:Homo sapiens


Alignment Length:975 Identity:327/975 - (33%)
Similarity:476/975 - (48%) Gaps:273/975 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 IEDYEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVL 75
            |||::|.:|||||.||.||:|..:||..:|||||||||.:...|:..||:.||:||.:|||||:|
Human    10 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSIL 74

  Fly    76 QLYTFFQDANYVYLVLELAHNGELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMHRDIS 140
            :||.:|:|:||||||||:.||||::||:.:..:||:|.||...:.|::.|:||||||.|:|||::
Human    75 ELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLT 139

  Fly   141 LSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYT 205
            ||||||:|.|::||||||||||||.|.|:|.|:||||||||||:.:|::|||.:||||:|||.||
Human   140 LSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYT 204

  Fly   206 LLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKC 270
            ||:|||||:||.|::||||||:::|.||:.||.||:|||::||::.|.:|::|.:||.||||.:.
Human   205 LLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRN 269

  Fly   271 S--------------NGGHSA-----------------------------PGALNVFSQSMESGD 292
            |              :.||:.                             |..:.||.::..|.|
Human   270 SSTKSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTD 334

  Fly   293 SGIITFASSDSRNSQQI----RSVENSGPQQVLPQIREEFKQVHHKLPY---------------- 337
                 |:||...||...    :...|||..:|:....|.....:.:..|                
Human   335 -----FSSSGDGNSFYTQWGNQETSNSGRGRVIQDAEERPHSRYLRRAYSSDRSGTSNSQSQAKT 394

  Fly   338 -----------------------------------------EQT----GLF-------------- 343
                                                     |:|    |.|              
Human   395 YTMERCHSAEMLSVSKRSGGGENEERYSPTDNNANIFNFFKEKTSSSSGSFERPDNNQALSNHLC 459

  Fly   344 -GQASTGLAEP--------NWPGAAKSSAFCMEAGNV----PN-------------SKQA----- 377
             |:.....|:|        .|.|..:.:|...:....    ||             ||.|     
Human   460 PGKTPFPFADPTPQTETVQQWFGNLQINAHLRKTTEYDSISPNRDFQGHPDLQKDTSKNAWTDTK 524

  Fly   378 ------------SLKED-----------------------------------------------R 383
                        |:|:.                                               |
Human   525 VKKNSDASDNAHSVKQQNTMKYMTALHSKPEIIQQECVFGSDPLSEQSKTRGMEPPWGYQNRTLR 589

  Fly   384 ISVPPLNTKRLLPTRYKTKNAIMSILRNGEVVLEFLKFRPTY-NEDRINDICRISDDGQRIIIYQ 447
            ....||...||.|.|.|||.|::|||.:.||.:|.:|   .| :::.:.::.:||.||..|.||.
Human   590 SITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVK---EYASQEYVKEVLQISSDGNTITIYY 651

  Fly   448 PDPGRGLPVREQPPDLQIPSGDCV-YNYDNLPSKHWKKYIYGARFVGLVKSKTPKVTYFSTLGKC 511
            |:.|||.|:.::||.   |:.:.. |::||||.|:|:||.|.:|||.||:||:||:|||:...||
Human   652 PNGGRGFPLADRPPS---PTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKC 713

  Fly   512 QLMETM--TDFEIRFYSGAKLLKTPSEGLKVYDRNGMLLSDYSCSESRSL-------IEHGNECF 567
            .|||..  .|||:.||.|.|:.|| .:.::|.::.|...:..|.||..||       ::|.||..
Human   714 ILMENSPGADFEVWFYDGVKIHKT-EDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGH 777

  Fly   568 THCVNISNALEVAQTKDNSC--FPVTIGRRPITDVQPAQRLDGLRDTTNIAFSTPKSNQGSINFS 630
            ..|:.:.:.:...:.|..|.  ||:.|||:|.:...|    ..|....::..:.|...:.|.|..
Human   778 RICLALESIISEEERKTRSAPFFPIIIGRKPGSTSSP----KALSPPPSVDSNYPTRERASFNRM 838

  Fly   631 L--STISSTR----------------NTSDFGTNCSRSNMLAAHQNIP-----IKRINVPEIGIA 672
            :  |..|.|:                .|:..||:.| ||.|  ...:|     :|.:.|..:|.|
Human   839 VMHSAASPTQAPILNPSMVTNEGLGLTTTASGTDIS-SNSL--KDCLPKSAQLLKSVFVKNVGWA 900

  Fly   673 TELSHGVVQVQFYDGSVVSVIPSMQGG--GITYTQPNGTSTHFGKGDDLPFPVRDRVGQIPNIQL 735
            |:|:.|.|.|||.|||.:.|    |.|  .|:||.|||.:|.:|:.:.||..::.::..:.:|.|
Human   901 TQLTSGAVWVQFNDGSQLVV----QAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILL 961

  Fly   736  735
            Human   962  961

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SAKNP_649324.1 STKc_PLK4 12..267 CDD:271088 154/254 (61%)
S_TKc 14..267 CDD:214567 152/252 (60%)
POLO_box_Plk4_1 382..497 CDD:240557 49/163 (30%)
POLO_box_Plk4_2 498..596 CDD:240558 38/108 (35%)
POLO_box_Plk4_3 657..738 CDD:240559 30/86 (35%)
PLK4XP_016863151.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165148766
Domainoid 1 1.000 344 1.000 Domainoid score I1058
eggNOG 1 0.900 - - E1_KOG0575
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H7962
Inparanoid 1 1.050 542 1.000 Inparanoid score I1180
Isobase 1 0.950 - 0 Normalized mean entropy S2938
OMA 1 1.010 - - QHG50064
OrthoDB 1 1.010 - - D342340at33208
OrthoFinder 1 1.000 - - FOG0007296
OrthoInspector 1 1.000 - - oto88500
orthoMCL 1 0.900 - - OOG6_106331
Panther 1 1.100 - - LDO PTHR24345
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R9746
SonicParanoid 1 1.000 - - X5399
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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