Protein Alignment SAK and PLK4

DIOPT Version :10

• Sequence 1: NP_649324.1
• Gene: SAK / 40384
• FlyBaseID: FBgn0026371
• Length: 769
• Species: Drosophila melanogaster
• Sequence 2: NP_001428286.1
• Gene: PLK4 / 10733
• HGNCID: 11397
• Length: 971
• Species: Homo sapiens
• Alignment Length: 975
• Identity: 327/975 - (33%)
• Similarity: 476/975 - (48%)
• Gaps: 273/975 - (28%)

  Fly    11 IEDYEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVL 75
            |||::|.:|||||.||.||:|..:||..:|||||||||.:...|:..||:.||:||.:|||||:|
Human    10 IEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSIL 74

  Fly    76 QLYTFFQDANYVYLVLELAHNGELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMHRDIS 140
            :||.:|:|:||||||||:.||||::||:.:..:||:|.||...:.|::.|:||||||.|:|||::
Human    75 ELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLT 139

  Fly   141 LSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYT 205
            ||||||:|.|::||||||||||||.|.|:|.|:||||||||||:.:|::|||.:||||:|||.||
Human   140 LSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYT 204

  Fly   206 LLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKC 270
            ||:|||||:||.|::||||||:::|.||:.||.||:|||::||::.|.:|::|.:||.||||.:.
Human   205 LLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRN 269

  Fly   271 S--------------NGGHSA-----------------------------PGALNVFSQSMESGD 292
            |              :.||:.                             |..:.||.::..|.|
Human   270 SSTKSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTD 334

  Fly   293 SGIITFASSDSRNSQQI----RSVENSGPQQVLPQIREEFKQVHHKLPY---------------- 337
                 |:||...||...    :...|||..:|:....|.....:.:..|
Human   335 -----FSSSGDGNSFYTQWGNQETSNSGRGRVIQDAEERPHSRYLRRAYSSDRSGTSNSQSQAKT 394

  Fly   338 -----------------------------------------EQT----GLF-------------- 343
                                                     |:|    |.|
Human   395 YTMERCHSAEMLSVSKRSGGGENEERYSPTDNNANIFNFFKEKTSSSSGSFERPDNNQALSNHLC 459

  Fly   344 -GQASTGLAEP--------NWPGAAKSSAFCMEAGNV----PN-------------SKQA----- 377
             |:.....|:|        .|.|..:.:|...:....    ||             ||.|
Human   460 PGKTPFPFADPTPQTETVQQWFGNLQINAHLRKTTEYDSISPNRDFQGHPDLQKDTSKNAWTDTK 524

  Fly   378 ------------SLKED-----------------------------------------------R 383
                        |:|:.                                               |
Human   525 VKKNSDASDNAHSVKQQNTMKYMTALHSKPEIIQQECVFGSDPLSEQSKTRGMEPPWGYQNRTLR 589

  Fly   384 ISVPPLNTKRLLPTRYKTKNAIMSILRNGEVVLEFLKFRPTY-NEDRINDICRISDDGQRIIIYQ 447
            ....||...||.|.|.|||.|::|||.:.||.:|.:|   .| :::.:.::.:||.||..|.||.
Human   590 SITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVK---EYASQEYVKEVLQISSDGNTITIYY 651

  Fly   448 PDPGRGLPVREQPPDLQIPSGDCV-YNYDNLPSKHWKKYIYGARFVGLVKSKTPKVTYFSTLGKC 511
            |:.|||.|:.::||.   |:.:.. |::||||.|:|:||.|.:|||.||:||:||:|||:...||
Human   652 PNGGRGFPLADRPPS---PTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKC 713

  Fly   512 QLMETM--TDFEIRFYSGAKLLKTPSEGLKVYDRNGMLLSDYSCSESRSL-------IEHGNECF 567
            .|||..  .|||:.||.|.|:.|| .:.::|.::.|...:..|.||..||       ::|.||..
Human   714 ILMENSPGADFEVWFYDGVKIHKT-EDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGH 777

  Fly   568 THCVNISNALEVAQTKDNSC--FPVTIGRRPITDVQPAQRLDGLRDTTNIAFSTPKSNQGSINFS 630
            ..|:.:.:.:...:.|..|.  ||:.|||:|.:...|    ..|....::..:.|...:.|.|..
Human   778 RICLALESIISEEERKTRSAPFFPIIIGRKPGSTSSP----KALSPPPSVDSNYPTRERASFNRM 838

  Fly   631 L--STISSTR----------------NTSDFGTNCSRSNMLAAHQNIP-----IKRINVPEIGIA 672
            :  |..|.|:                .|:..||:.| ||.|  ...:|     :|.:.|..:|.|
Human   839 VMHSAASPTQAPILNPSMVTNEGLGLTTTASGTDIS-SNSL--KDCLPKSAQLLKSVFVKNVGWA 900

  Fly   673 TELSHGVVQVQFYDGSVVSVIPSMQGG--GITYTQPNGTSTHFGKGDDLPFPVRDRVGQIPNIQL 735
            |:|:.|.|.|||.|||.:.|    |.|  .|:||.|||.:|.:|:.:.||..::.::..:.:|.|
Human   901 TQLTSGAVWVQFNDGSQLVV----QAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILL 961

  Fly   736  735
            Human   962  961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	154/254 (61%)
		POLO_box_Plk4_1	382..497	CDD:240557	49/163 (30%)
		POLO_box_Plk4_2	498..596	CDD:240558	38/108 (35%)
		POLO_box_Plk4_3	657..738	CDD:240559	30/86 (35%)
PLK4	NP_001428286.1	None