DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SAK and plk5

DIOPT Version :9

Sequence 1:	NP_649324.1	Gene:	SAK / 40384	FlyBaseID:	FBgn0026371	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	XP_002941168.2	Gene:	plk5 / 100487804	-ID:	-	Length:	609	Species:	Xenopus tropicalis

Alignment Length:	544	Identity:	139/544 - (25%)
Similarity:	218/544 - (40%)	Gaps:	160/544 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 YEVQHLLGKGGFATVYKARCLHTHQDVAIKMID-----KKLIQGTGLTNRVRQEVEIHSRLKHPS 73
            |....|||||.|...||.....:.|..|:|||.     .|..:| |:.|    |:|:|..|||.:
Frog    27 YRRGKLLGKGAFGRCYKFTDASSRQVFAVKMISHTRKIHKFYRG-GVEN----EIELHCNLKHKN 86

  Fly    74 VLQLYTFFQDANYVYLVLELAHNGELHRYMNHIARP---FTETEAASILKQVVAGLLYLHSHNIM 135
            :::.|..|:|..|:|:|||...    |:.:.||.|.   .||.|....:||::.|:|.||...|:
Frog    87 IVRFYHHFEDQKYMYMVLEYCR----HKSLAHILRVRKLLTEPEVRYYMKQILQGILCLHQQGII 147

  Fly   136 HRDISLSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVG 200
            |||:.|||..:::.|.|||.|.||||.:::.::....:||||||:||||::::.|...:|:|::|
Frog   148 HRDLKLSNFFIAKNMIVKIGDLGLATTVEQCEKLPGVICGTPNYLSPEVLAKSGHSFKSDIWALG 212

  Fly   201 CMLYTLLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHP 265
            |::||:|.|..||...:.:.....:....:.:|..:|..|:.||..||...|..|..||.:..:.
Frog   213 CIMYTMLTGYSPFRARSQKEMYYFIREGFFPVPTFISLSARRLIISLLASCPDNRPCLEEIFAND 277

  Fly   266 FMLK-------CSNGGHSAPG-------------ALNVFSQSM-------------ESGDSGII- 296
            |:.|       .|...|:||.             |.||..:.:             |.|:|.|:
Frog   278 FLTKGFTPERLSSTMCHTAPNFTFTNHFTRLFRKAANVLYRGVFQKPFCTDCSVRGEDGNSNIMP 342

  Fly   297 -----------------TFAS---------------------------SDSRNSQQIRSVENSGP 317
                             :|.|                           :|.|..:.:..:.....
Frog   343 INTHTRLGNNKGEEPEDSFRSCSESLIVLMKGSMSPRRMSPSHSQTDMTDDRVVEDMTVMLQRCL 407

  Fly   318 QQVLPQIREEFKQV-------------------HHKLPYEQTG-LFGQA--------------ST 348
            |.::|.:.:...||                   .::|..:..| ||...              ||
Frog   408 QNMMPGLLDPNYQVTCPILWVTKWMDYSNKYGFGYQLSDDCVGVLFNDGSHITLNPHLQKVCYST 472

  Fly   349 GLAE----PNWPGAAKSSA-------FC-------MEAGNVPNSKQASLKEDRISVPPLNTKRLL 395
            ..:|    |.|....:...       ||       ||.|:|.            :.|.|..:.|.
Frog   473 SSSEHVTFPEWSPPCRMDIKMKILQFFCEYMQEKIMEGGDVR------------AEPTLTVRTLC 525

  Fly   396 PTRY-KTKNAIMSILRNGEVVLEF 418
            ...: ||..|::.|..||.:.:.|
Frog   526 LMHFLKTDQALLMIFSNGTLQVNF 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	93/260 (36%)
		S_TKc	14..267	CDD:214567	93/260 (36%)
		POLO_box_Plk4_1	382..497	CDD:240557	10/38 (26%)
		POLO_box_Plk4_2	498..596	CDD:240558
		POLO_box_Plk4_3	657..738	CDD:240559
plk5	XP_002941168.2	PKc_like	27..279	CDD:389743	93/260 (36%)
		POLO_box_1	424..512	CDD:240561	13/87 (15%)
		POLO_box_2	526..606	CDD:240560	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D507604at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920