Protein Alignment SAK and plk4

DIOPT Version :10

• Sequence 1: NP_649324.1
• Gene: SAK / 40384
• FlyBaseID: FBgn0026371
• Length: 769
• Species: Drosophila melanogaster
• Sequence 2: XP_012814446.2
• Gene: plk4 / 100038180
• XenbaseID: XB-GENE-493608
• Length: 978
• Species: Xenopus tropicalis
• Alignment Length: 947
• Identity: 339/947 - (35%)
• Similarity: 472/947 - (49%)
• Gaps: 243/947 - (25%)

  Fly    11 IEDYEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVL 75
            |||::|.:|||||.||.||:|:.::|..||||||||||.:|..|:..|||.|||||.:|||||:|
 Frog    41 IEDFKVLNLLGKGSFACVYRAQSINTGIDVAIKMIDKKAMQKVGMVQRVRNEVEIHCQLKHPSIL 105

  Fly    76 QLYTFFQDANYVYLVLELAHNGELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMHRDIS 140
            :||.:|:|:|||||:||:.||||::|::.:..:||:|.||...:.|:|.|:||||||.|:|||::
 Frog   106 ELYNYFEDSNYVYLILEMCHNGEMNRFLKNRKKPFSEDEARHFMHQIVTGMLYLHSHGILHRDLT 170

  Fly   141 LSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYT 205
            |||||||.:|::||||||||||||.|:|:|.|||||||||:||:.:|::|||.:||||:||||||
 Frog   171 LSNLLLSSDMNIKIADFGLATQLKMPNEKHFTMCGTPNYIAPEIATRSAHGLESDVWSLGCMLYT 235

  Fly   206 LLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKC 270
            .|||||||:||.|::||||:|:::|.||..:|.||:|||.:||:|.|.:|::|.:||.|.||...
 Frog   236 FLVGRPPFDTDTVKNTLNKIVLADYEMPDFVSREAKDLIFQLLRKNPADRLSLSSVLDHAFMTGF 300

  Fly   271 SN--------------GGH----------------------------SAPGALNVF--------- 284
            ||              .||                            |.|..:|:|
 Frog   301 SNVQSKVMGAVEDSIDSGHATISTGFTGSSGVSISGRFQEKRILSGPSLPNKVNIFQFRDKHPAE 365

  Fly   285 --------SQSMESGD----SGIITFASSDSRNSQQIR---SVENSGPQQV-------------- 320
                    :...|:.|    :|..|.|..|..:|:.:|   |.:.||..|.
 Frog   366 RSNGGSFHNTQRENNDFSEGNGRKTVACEDRPHSRYLRRAHSSDRSGTSQSQTYGKPSSFSERCH 430

  Fly   321 -------------------------LPQI--------REEFKQVHHKLPYE----------QTGL 342
                                     :||:        |.....|..|.|.|          ::|.
 Frog   431 SVEMLAKPSNLKGYCTSSPPKSYGDIPQMFTDERSLERHTSPPVKEKTPSEFMCPAKQITPRSGD 495

  Fly   343 FGQASTGLAEPNWPGAAKSSAFCMEAGNVPNSKQAS-------------------------LKED 382
            ..||.|   ...|.||.:.:.   :..|.|::...|                         .|:|
 Frog   496 KCQAET---VQQWFGAMQLNG---KFKNTPDTSSVSNMGGDFYSQQTMQNGAPQYAWNDVKRKKD 554

  Fly   383 ---------------------------------------------RISVPPLNTKRLLPTRYKTK 402
                                                         |..:.|||.:||.|.|.|||
 Frog   555 TDSSVESVLRGISKLPSGQHKAEKSQFGEQSKARVPQQAFGSSTLRSIISPLNAERLKPIRQKTK 619

  Fly   403 NAIMSILRNGEVVLEFLKFRPTYNEDRINDICRISDDGQRIIIYQPDPGRGLPVREQPPDLQIPS 467
            ||::|||..|||.:||||  ...:::|:.::.|||.||..|.:|.|:.|:|.|:.|:||  ..|.
 Frog   620 NAVVSILETGEVCMEFLK--EQNSQERVKEVLRISCDGNLIYVYHPNEGKGFPLVERPP--SPPE 680

  Fly   468 GDCVYNYDNLPSKHWKKYIYGARFVGLVKSKTPKVTYFSTLGKCQLMET--MTDFEIRFYSGAKL 530
            ....|.:|:||.|:||||.|.|:|:.||:||.|||||::...||.|||.  ..|||:.||.|||:
 Frog   681 NMRSYTFDSLPEKYWKKYQYAAKFIQLVRSKMPKVTYYTRYAKCMLMENGPNADFEVCFYDGAKI 745

  Fly   531 LKTP------SEGLKVYDRNGMLLSDYSCSESRSLIEHGNECFTHCVNISNALEVAQTKDN--SC 587
            .|||      .:..|.|...|..||..| .:.||.:.|.||....|:::.:|:...:.|..  |.
 Frog   746 HKTPDLIRVIEKSGKSYTVEGSRLSTLS-DQVRSYVNHANESHCVCLSLESAINTEEKKGENISL 809

  Fly   588 FPVTIGRRPITDVQPAQRL--DGLRDTTNIAFST--------------PKSNQGSINFSLSTISS 636
            ||:|.||||.....|..:|  |..|:..:...|.              |..|...|::..|..|:
 Frog   810 FPITFGRRPAITESPRTQLTIDSARERKDEQSSANRVLHSSATSPPQMPNINPSLISYEGSVFSA 874

  Fly   637 TRNTSDFGTNCSRSNMLAAHQNIP-----IKRINVPEIGIATELSHGVVQVQFYDGSVVSVIPSM 696
            |.......|    ||.|..|  .|     :|.:.|..:|.|::|:.|.|.|||.|||.:.|.|.:
 Frog   875 TTAQPSPPT----SNTLKTH--APDRAQVLKSVFVENVGWASQLNSGAVWVQFNDGSQLVVQPGV 933

  Fly   697 QGGGITYTQPNGTSTHFGKGDDLPFPVRDRVGQIPNI 733
              ..|.||.|||..|..|:.|.||..::.::..:.:|
 Frog   934 --SSIIYTAPNGQITRHGENDKLPEYIKSKLQCLSSI 968

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	155/254 (61%)
		POLO_box_Plk4_1	382..497	CDD:240557	54/159 (34%)
		POLO_box_Plk4_2	498..596	CDD:240558	42/107 (39%)
		POLO_box_Plk4_3	657..738	CDD:240559	28/82 (34%)
plk4	XP_012814446.2	STKc_PLK4	42..297	CDD:271088	155/254 (61%)
		POLO_box_Plk4_1	599..710	CDD:240557	53/114 (46%)
		POLO_box_Plk4_2	711..818	CDD:240558	42/107 (39%)
		POLO_box_Plk4_3	895..973	CDD:240559	27/76 (36%)