DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SAK and plk4

DIOPT Version :9

Sequence 1:	NP_649324.1	Gene:	SAK / 40384	FlyBaseID:	FBgn0026371	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	XP_012814446.2	Gene:	plk4 / 100038180	XenbaseID:	XB-GENE-493608	Length:	978	Species:	Xenopus tropicalis

Alignment Length:	947	Identity:	339/947 - (35%)
Similarity:	472/947 - (49%)	Gaps:	243/947 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IEDYEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNRVRQEVEIHSRLKHPSVL 75
            |||::|.:|||||.||.||:|:.::|..||||||||||.:|..|:..|||.|||||.:|||||:|
Frog    41 IEDFKVLNLLGKGSFACVYRAQSINTGIDVAIKMIDKKAMQKVGMVQRVRNEVEIHCQLKHPSIL 105

  Fly    76 QLYTFFQDANYVYLVLELAHNGELHRYMNHIARPFTETEAASILKQVVAGLLYLHSHNIMHRDIS 140
            :||.:|:|:|||||:||:.||||::|::.:..:||:|.||...:.|:|.|:||||||.|:|||::
Frog   106 ELYNYFEDSNYVYLILEMCHNGEMNRFLKNRKKPFSEDEARHFMHQIVTGMLYLHSHGILHRDLT 170

  Fly   141 LSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYT 205
            |||||||.:|::||||||||||||.|:|:|.|||||||||:||:.:|::|||.:||||:||||||
Frog   171 LSNLLLSSDMNIKIADFGLATQLKMPNEKHFTMCGTPNYIAPEIATRSAHGLESDVWSLGCMLYT 235

  Fly   206 LLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPFMLKC 270
            .|||||||:||.|::||||:|:::|.||..:|.||:|||.:||:|.|.:|::|.:||.|.||...
Frog   236 FLVGRPPFDTDTVKNTLNKIVLADYEMPDFVSREAKDLIFQLLRKNPADRLSLSSVLDHAFMTGF 300

  Fly   271 SN--------------GGH----------------------------SAPGALNVF--------- 284
            ||              .||                            |.|..:|:|
Frog   301 SNVQSKVMGAVEDSIDSGHATISTGFTGSSGVSISGRFQEKRILSGPSLPNKVNIFQFRDKHPAE 365

  Fly   285 --------SQSMESGD----SGIITFASSDSRNSQQIR---SVENSGPQQV-------------- 320
                    :...|:.|    :|..|.|..|..:|:.:|   |.:.||..|.
Frog   366 RSNGGSFHNTQRENNDFSEGNGRKTVACEDRPHSRYLRRAHSSDRSGTSQSQTYGKPSSFSERCH 430

  Fly   321 -------------------------LPQI--------REEFKQVHHKLPYE----------QTGL 342
                                     :||:        |.....|..|.|.|          ::|.
Frog   431 SVEMLAKPSNLKGYCTSSPPKSYGDIPQMFTDERSLERHTSPPVKEKTPSEFMCPAKQITPRSGD 495

  Fly   343 FGQASTGLAEPNWPGAAKSSAFCMEAGNVPNSKQAS-------------------------LKED 382
            ..||.|   ...|.||.:.:.   :..|.|::...|                         .|:|
Frog   496 KCQAET---VQQWFGAMQLNG---KFKNTPDTSSVSNMGGDFYSQQTMQNGAPQYAWNDVKRKKD 554

  Fly   383 ---------------------------------------------RISVPPLNTKRLLPTRYKTK 402
                                                         |..:.|||.:||.|.|.|||
Frog   555 TDSSVESVLRGISKLPSGQHKAEKSQFGEQSKARVPQQAFGSSTLRSIISPLNAERLKPIRQKTK 619

  Fly   403 NAIMSILRNGEVVLEFLKFRPTYNEDRINDICRISDDGQRIIIYQPDPGRGLPVREQPPDLQIPS 467
            ||::|||..|||.:||||  ...:::|:.::.|||.||..|.:|.|:.|:|.|:.|:||  ..|.
Frog   620 NAVVSILETGEVCMEFLK--EQNSQERVKEVLRISCDGNLIYVYHPNEGKGFPLVERPP--SPPE 680

  Fly   468 GDCVYNYDNLPSKHWKKYIYGARFVGLVKSKTPKVTYFSTLGKCQLMET--MTDFEIRFYSGAKL 530
            ....|.:|:||.|:||||.|.|:|:.||:||.|||||::...||.|||.  ..|||:.||.|||:
Frog   681 NMRSYTFDSLPEKYWKKYQYAAKFIQLVRSKMPKVTYYTRYAKCMLMENGPNADFEVCFYDGAKI 745

  Fly   531 LKTP------SEGLKVYDRNGMLLSDYSCSESRSLIEHGNECFTHCVNISNALEVAQTKDN--SC 587
            .|||      .:..|.|...|..||..| .:.||.:.|.||....|:::.:|:...:.|..  |.
Frog   746 HKTPDLIRVIEKSGKSYTVEGSRLSTLS-DQVRSYVNHANESHCVCLSLESAINTEEKKGENISL 809

  Fly   588 FPVTIGRRPITDVQPAQRL--DGLRDTTNIAFST--------------PKSNQGSINFSLSTISS 636
            ||:|.||||.....|..:|  |..|:..:...|.              |..|...|::..|..|:
Frog   810 FPITFGRRPAITESPRTQLTIDSARERKDEQSSANRVLHSSATSPPQMPNINPSLISYEGSVFSA 874

  Fly   637 TRNTSDFGTNCSRSNMLAAHQNIP-----IKRINVPEIGIATELSHGVVQVQFYDGSVVSVIPSM 696
            |.......|    ||.|..|  .|     :|.:.|..:|.|::|:.|.|.|||.|||.:.|.|.:
Frog   875 TTAQPSPPT----SNTLKTH--APDRAQVLKSVFVENVGWASQLNSGAVWVQFNDGSQLVVQPGV 933

  Fly   697 QGGGITYTQPNGTSTHFGKGDDLPFPVRDRVGQIPNI 733
              ..|.||.|||..|..|:.|.||..::.::..:.:|
Frog   934 --SSIIYTAPNGQITRHGENDKLPEYIKSKLQCLSSI 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	155/254 (61%)
		S_TKc	14..267	CDD:214567	153/252 (61%)
		POLO_box_Plk4_1	382..497	CDD:240557	54/159 (34%)
		POLO_box_Plk4_2	498..596	CDD:240558	42/107 (39%)
		POLO_box_Plk4_3	657..738	CDD:240559	28/82 (34%)
plk4	XP_012814446.2	STKc_PLK4	42..297	CDD:271088	155/254 (61%)
		POLO_box_Plk4_1	599..710	CDD:240557	53/114 (46%)
		POLO_box_Plk4_2	711..818	CDD:240558	42/107 (39%)
		POLO_box_Plk4_3	895..973	CDD:240559	27/76 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	341	1.000	Domainoid score	I1080
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7962
Inparanoid	1	1.050	570	1.000	Inparanoid score	I1049
OMA	1	1.010	-	-		QHG50064
OrthoDB	1	1.010	-	-		D342340at33208
OrthoFinder	1	1.000	-	-		FOG0007296
OrthoInspector	1	1.000	-	-		otm47552
Panther	1	1.100	-	-	LDO	PTHR24345
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9746
SonicParanoid	1	1.000	-	-		X5399
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110