DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SAK and pimr52

DIOPT Version :9

Sequence 1:	NP_649324.1	Gene:	SAK / 40384	FlyBaseID:	FBgn0026371	Length:	769	Species:	Drosophila melanogaster
Sequence 2:	XP_021333990.1	Gene:	pimr52 / 100006411	ZFINID:	ZDB-GENE-070912-460	Length:	336	Species:	Danio rerio

Alignment Length:	252	Identity:	75/252 - (29%)
Similarity:	107/252 - (42%)	Gaps:	44/252 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 EDYEVQHLLGKGGFATVYKARCLHTHQDVAIKMIDKK------LIQGTGLTNRVRQEVEIHSRLK 70
            :.|....|||:|||.:|:..........||||.:.|:      .:.|.|   |:..||.:.:|:.
Zfish    78 DQYAKGPLLGRGGFGSVFAGIRRSDGLPVAIKYVSKEPTDTRLKVDGQG---RLPLEVALMTRVS 139

  Fly    71 H----PSVLQLYTFFQDANYVYLVLE-----------LAHNGELHRYMNHIARPFTETEAASILK 120
            .    ||||||..:|.......|:||           ...||.|           .|..|..:|.
Zfish   140 SAPVCPSVLQLLDWFDHRRRYVLILERPAPCQDLQSFCEENGCL-----------DEPLAKKVLV 193

  Fly   121 QVVAGLLYLHSHNIMHRDISLSNLLLSREMH-VKIADFGLATQLKRPDERHMTMCGTPNYISPE- 183
            |::|.|.:..|..::|||:...|||:|.:.| :|:.|||....:|  |..:....|||.:..||
Zfish   194 QLIAALKHCESRRVLHRDVKPENLLISTDSHDIKLLDFGCGDLMK--DSAYRYFAGTPAFAPPEW 256

  Fly   184 VVSRTSHGLPADVWSVGCMLYTLLVGRPPFETDAVQSTLNKVVMSEYIMPAHLSYEA 240
            ......|..|..|||:|..||.:|....||.  ..:...:|   |....|..||.:|
Zfish   257 FRHHRYHASPLTVWSIGVTLYNILCDCFPFR--GARRVTSK---SRLHFPRKLSTDA 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SAK	NP_649324.1	STKc_PLK4	12..267	CDD:271088	75/252 (30%)
		S_TKc	14..267	CDD:214567	75/250 (30%)
		POLO_box_Plk4_1	382..497	CDD:240557
		POLO_box_Plk4_2	498..596	CDD:240558
		POLO_box_Plk4_3	657..738	CDD:240559
pimr52	XP_021333990.1	PKc_like	79..308	CDD:328722	74/249 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000