Protein Alignment M6 and PLP1

DIOPT Version :9

• Sequence 1: NP_001262166.1
• Gene: M6 / 40383
• FlyBaseID: FBgn0037092
• Length: 368
• Species: Drosophila melanogaster
• Sequence 2: NP_000524.3
• Gene: PLP1 / 5354
• HGNCID: 9086
• Length: 277
• Species: Homo sapiens
• Alignment Length: 280
• Identity: 67/280 - (23%)
• Similarity: 110/280 - (39%)
• Gaps: 76/280 - (27%)

  Fly   123 ECCQSCMARIPYATLIATLMCLLGVGIFCFTMYRGASLTVIMVD-------QVFHLRLIWIEAVQ 180
            |||..|:...|:|:|:||.:|..||.:||...:...:.|..:::       |.:...:..|.|.|
Human     5 ECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQ 69

  Fly   181 MIFVIIGAG--MAALGFMILFVGFLATGATRYKVYRAWRSRVGGR-ISCAV-------------- 228
              :||.|..  ....|.::|..||..|||.| :::..:::.:.|: :|..|
Human    70 --YVIYGTASFFFLYGALLLAEGFYTTGAVR-QIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQ 131

  Fly   229 --------------------LMGITYLLNFVWSLILCFLVVVTFIYTMFWNMC--------TSVE 265
                                .:||||.|..||.|:.....|..:||...|..|        ||..
Human   132 AHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSAS 196

  Fly   266 HSQSCIDLTQFHFM----FPPNTKLEDMKVCEKYEIKAFCKDGVENAEV-----MFILATLSTLL 321
            ....|.|...:..:    ||.       |||.. .:.:.||    .||.     :||.|.:....
Human   197 IGSLCADARMYGVLPWNAFPG-------KVCGS-NLLSICK----TAEFQMTFHLFIAAFVGAAA 249

  Fly   322 VLLSLVHYLMCLSANYAHIR 341
            .|:||:.:::..:.|:|.::
Human   250 TLVSLLTFMIAATYNFAVLK 269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
M6	NP_001262166.1	Myelin_PLP	123..345	CDD:279599	67/280 (24%)
PLP1	NP_000524.3	Myelin_PLP	5..273	CDD:396024	67/280 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142557
Domainoid	1	1.000	106	1.000	Domainoid score	I6572
eggNOG	1	0.900	-	-		E1_KOG4800
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	115	1.000	Inparanoid score	I4832
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D390385at33208
OrthoFinder	1	1.000	-	-		FOG0001336
OrthoInspector	1	1.000	-	-		otm40989
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11683
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.900