Protein Alignment M6 and PLP1

DIOPT Version :10

• Sequence 1: NP_001262166.1
• Gene: M6 / 40383
• FlyBaseID: FBgn0037092
• Length: 368
• Species: Drosophila melanogaster
• Sequence 2: NP_000524.3
• Gene: PLP1 / 5354
• HGNCID: 9086
• Length: 277
• Species: Homo sapiens
• Alignment Length: 349
• Identity: 77/349 - (22%)
• Similarity: 129/349 - (36%)
• Gaps: 83/349 - (23%)

  Fly    10 ENGSLRFVDFVNKTFALLGNSPI----KKFS--LRHEPRLYCVDAYLRWI-----FTAMEQERGL 63
            |.|.|.||  |...|.|:.....    ||.|  :..:.||    ..|:||     ...::::...
Human   569 EKGYLIFV--VRFLFGLVNQERTSYLEKKLSCKISQQVRL----ELLKWIEVKAKAKKLQRQPSQ 627

  Fly    64 LELHLYADRYYYPVGIERELFTSNTL-----VKLTLSGRYDFQVETVFLPALKSLSLSSSFEIGF 123
            |||      :|....::.|.|..:.:     :::.||.|.|..|.:.   .:|:.....:..:||
Human   628 LEL------FYCLYEMQEEDFVQSAMGHFPKIEINLSTRMDHVVSSF---CIKNCHRVKTLSLGF 683

  Fly   124 DKYCNLLDGFPALEELYIREAVSELSNALLSSGTFVKCASIKRLVVFTDCPKFKEDEDHQEPCFI 188
                  |...|..||...|.:........:.....|.|:|  |||                .|.:
Human   684 ------LHNSPKEEEEEKRGSQPLDQVQCVFPDPHVACSS--RLV----------------NCCL 724

  Fly   189 APSLVYLDYSSYLSENYDLIDL----NSLVEARLNLRLLESFNNYGSS------DNDGDVYGWDF 243
            ..|.....:|| ||.|..|.:|    |:|.:..:.: |.|:..:.|.:      ...|..:...|
Human   725 TSSFCRGLFSS-LSTNQSLTELDLSDNTLGDPGMRV-LCEALQHPGCNIQRLWLGRCGLTHQCCF 787

  Fly   244 NVPFDYYGDVTNLVAGITNITTLHLSPDSLEVFHFRCKSIPVFNNLLLNLSIESNKRNGWQVMPL 308
            |        ::::::....:..|.||.::|..|..|...:.: .:||.||      :..|.|...
Human   788 N--------ISSVLSSSQKLVELDLSDNALGDFGVRLLCVGL-KHLLCNL------QKLWLVSCC 837

  Fly   309 LIRSCPNLHTLVIKVLSFSLLRFF 332
            |..:|.....||:. .:.||.|.:
Human   838 LTSACCQDLALVLS-SNHSLTRLY 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
M6	NP_001262166.1	Myelin_PLP	122..345	CDD:460144	49/221 (22%)
PLP1	NP_000524.3	Myelin_PLP	5..273	CDD:460144