DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment M6 and gpm6ab

DIOPT Version :9

Sequence 1:	NP_001262166.1	Gene:	M6 / 40383	FlyBaseID:	FBgn0037092	Length:	368	Species:	Drosophila melanogaster
Sequence 2:	XP_005160038.1	Gene:	gpm6ab / 407734	ZFINID:	ZDB-GENE-030710-8	Length:	285	Species:	Danio rerio

Alignment Length:	288	Identity:	82/288 - (28%)
Similarity:	141/288 - (48%)	Gaps:	38/288 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 DHSLDRYTERGGEGECCQSCMARIPYATLIATLMCLLGVGIFCFTMYRGASLTVIMVDQVFHLRL 173
            :.:::....:.|..|||..|::.||||:||||::...||.:||...:...|.||.::...|.:..
Zfish     2 EENMEEGQTQKGCSECCLKCLSGIPYASLIATILLYAGVALFCGCGHEALSGTVTILQTYFDVVR 66

  Fly   174 IWIEAVQMI-------FVIIGAGMA--ALGFMILFVGFLATGATRYKVYRAWRSRVGGRISCAVL 229
            ..::|:.:.       :||.|...|  ..|.:::..||..|||.| .:|..::....||...|..
Zfish    67 SPVDALDVFTMIDIFKYVIYGVAAAFFVYGILLMVEGFFTTGAIR-DLYGDFKITTCGRCVSAWF 130

  Fly   230 MGITYLLNFVWSLILCFLVVVTFIYTMFWNMC---TSVEHSQS-------CIDLTQFHFMFPPNT 284
            :.:||:....|..:..|..:..|:|...||.|   |.:|.|.|       |.||.|:..:    :
Zfish   131 IMLTYIFMLAWLGVTAFTSLPVFMYFNIWNTCQNMTLLEGSLSSANSANLCFDLRQYGIV----S 191

  Fly   285 KLEDMKVCEKYE-IKAFCKDGVENAEV-----MFILATLSTLLVLLSLVHYLMCLSANYAHIRDH 343
            ..|:.::|...| .|..|    |:.|:     :|:.|.......::::|||||.||||:|:::|.
Zfish   192 IGEEKRLCADNENFKKMC----ESNELDLTFHLFVCALAGAGAAVIAMVHYLMVLSANWAYVKDA 252

  Fly   344 EKFQELQEIQNLNELE----YSATSKDR 367
            .:.|:.::|::..|.|    :|..||:|
Zfish   253 CRMQKYEDIKSKEEQELHDIHSTRSKER 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
M6	NP_001262166.1	Myelin_PLP	123..345	CDD:279599	73/246 (30%)
gpm6ab	XP_005160038.1	Myelin_PLP	14..254	CDD:279599	73/248 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575281
Domainoid	1	1.000	102	1.000	Domainoid score	I6773
eggNOG	1	0.900	-	-		E1_KOG4800
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	112	1.000	Inparanoid score	I4839
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D390385at33208
OrthoFinder	1	1.000	-	-		FOG0001336
OrthoInspector	1	1.000	-	-		otm24778
orthoMCL	1	0.900	-	-		OOG6_107551
Panther	1	1.100	-	-	LDO	PTHR11683
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5557
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790