Protein Alignment M6 and GPM6B

DIOPT Version :9

• Sequence 1: NP_001262166.1
• Gene: M6 / 40383
• FlyBaseID: FBgn0037092
• Length: 368
• Species: Drosophila melanogaster
• Sequence 2: NP_001001995.1
• Gene: GPM6B / 2824
• HGNCID: 4461
• Length: 328
• Species: Homo sapiens
• Alignment Length: 350
• Identity: 86/350 - (24%)
• Similarity: 145/350 - (41%)
• Gaps: 98/350 - (28%)

  Fly    68 PREEILLETNFEDDGGVLTRAYNGNPYNPTIQNRRRNSYRSDHSLDRY----------------- 115
            |..|...|.|.|..                 |.|:.|| |::..:.||
Human     3 PAMETAAEENTEQS-----------------QERKVNS-RAEMEIGRYHWMYPGSKNHQYHPVPT 49

  Fly   116 -------TERGGEGECCQSCMARIPYATLIATLMCLLGVGIFCFTMYRGASLTVIMVDQVF---- 169
                   ....|..|||..|:..:|||:|:||::|..||.:||...:...:.||.:::|.|
Human    50 LGDRASPLSSPGCFECCIKCLGGVPYASLVATILCFSGVALFCGCGHVALAGTVAILEQHFSTNA 114

  Fly   170 --HLRLIWIEAVQMIFVIIGAGMAAL----GFMILFVGFLATGATRYKVYRAWRSRVGGRISCAV 228
              |..|  .|.:|::..:| .|:|:.    |.::|..||..|.|.: :::..:::...||....:
Human   115 SDHALL--SEVIQLMQYVI-YGIASFFFLYGIILLAEGFYTTSAVK-ELHGEFKTTACGRCISGM 175

  Fly   229 LMGITYLLNFVWSLILCFLVVVTFIYTMFWNMC-----------TSVEHSQSCIDLTQFHFM--- 279
            .:.:||:|...|..:..|..|..|::...|:.|           |.||  |.|:|:.|:..:
Human   176 FVFLTYVLGVAWLGVFGFSAVPVFMFYNIWSTCEVIKSPQTNGTTGVE--QICVDIRQYGIIPWN 238

  Fly   280 -FPPNTKLEDMKVCEKYEIKAFCKDGVEN---------AEVMFILATLSTLLVLLSLVHYLMCLS 334
             ||..                .|...:||         :..:||:|.......:::|:|:||.||
Human   239 AFPGK----------------ICGSALENICNTNEFYMSYHLFIVACAGAGATVIALIHFLMILS 287

  Fly   335 ANYAHIRDHEKFQELQEIQNLNELE 359
            :|:|:::|..|.|..|:|:...|.|
Human   288 SNWAYLKDASKMQAYQDIKAKEEQE 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
M6	NP_001262166.1	Myelin_PLP	123..345	CDD:279599	67/255 (26%)
GPM6B	NP_001001995.1	Myelin_PLP	62..298	CDD:396024	67/257 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142558
Domainoid	1	1.000	106	1.000	Domainoid score	I6572
eggNOG	1	0.900	-	-		E1_KOG4800
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	115	1.000	Inparanoid score	I4832
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D390385at33208
OrthoFinder	1	1.000	-	-		FOG0001336
OrthoInspector	1	1.000	-	-		otm40989
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11683
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.860