Protein Alignment M6 and GPM6A

DIOPT Version :9

• Sequence 1: NP_001262166.1
• Gene: M6 / 40383
• FlyBaseID: FBgn0037092
• Length: 368
• Species: Drosophila melanogaster
• Sequence 2: NP_005268.1
• Gene: GPM6A / 2823
• HGNCID: 4460
• Length: 278
• Species: Homo sapiens
• Alignment Length: 267
• Identity: 79/267 - (29%)
• Similarity: 130/267 - (48%)
• Gaps: 31/267 - (11%)

  Fly   123 ECCQSCMARIPYATLIATLMCLLGVGIFCFTMYRGASLTVIMVDQVFHLR---------LIWIEA 178
            |||..|:..||||:||||::...||.:||...:...|.||.::...|.:.         ...|:.
Human    16 ECCIKCLGGIPYASLIATILLYAGVALFCGCGHEALSGTVNILQTYFEMARTAGDTLDVFTMIDI 80

  Fly   179 VQMIFVIIGAGMAALGFMILFVGFLATGATRYKVYRAWRSRVGGRISCAVLMGITYLLNFVWSLI 243
            .:.:...|.|.....|.:::..||..|||.: .:|..::....||...|..:.:|||....|..:
Human    81 FKYVIYGIAAAFFVYGILLMVEGFFTTGAIK-DLYGDFKITTCGRCVSAWFIMLTYLFMLAWLGV 144

  Fly   244 LCFLVVVTFIYTMFWNMC---TSVEHSQSCIDLTQFHFMFPPNTKLEDMKVCEKYE-IKAFCKDG 304
            ..|..:..::|...|.:|   |.||.:..|:||.||..:    |..|:.|:|...| ....|
Human   145 TAFTSLPVYMYFNLWTICRNTTLVEGANLCLDLRQFGIV----TIGEEKKICTVSENFLRMC--- 202

  Fly   305 VENAEV-----MFILATLSTLLVLLSLVHYLMCLSANYAHIRDHEKFQELQEIQNLNELE----Y 360
             |:.|:     :||:|.......::::|||||.||||:|:::|..:.|:.::|::..|.|    :
Human   203 -ESTELNMTFHLFIVALAGAGAAVIAMVHYLMVLSANWAYVKDACRMQKYEDIKSKEEQELHDIH 266

  Fly   361 SATSKDR 367
            |..||:|
Human   267 STRSKER 273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
M6	NP_001262166.1	Myelin_PLP	123..345	CDD:279599	71/239 (30%)
GPM6A	NP_005268.1	Myelin_PLP	14..247	CDD:396024	71/239 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142559
Domainoid	1	1.000	106	1.000	Domainoid score	I6572
eggNOG	1	0.900	-	-		E1_KOG4800
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3864
Inparanoid	1	1.050	115	1.000	Inparanoid score	I4832
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D390385at33208
OrthoFinder	1	1.000	-	-		FOG0001336
OrthoInspector	1	1.000	-	-		otm40989
orthoMCL	1	0.900	-	-		OOG6_107551
Panther	1	1.100	-	-	LDO	PTHR11683
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5557
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790