DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment M6 and Plp1

DIOPT Version :9

Sequence 1:	NP_001262166.1	Gene:	M6 / 40383	FlyBaseID:	FBgn0037092	Length:	368	Species:	Drosophila melanogaster
Sequence 2:	NP_112252.1	Gene:	Plp1 / 24943	RGDID:	3354	Length:	277	Species:	Rattus norvegicus

Alignment Length:	280	Identity:	67/280 - (23%)
Similarity:	110/280 - (39%)	Gaps:	76/280 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 ECCQSCMARIPYATLIATLMCLLGVGIFCFTMYRGASLTVIMVD-------QVFHLRLIWIEAVQ 180
            |||..|:...|:|:|:||.:|..||.:||...:...:.|..:::       |.:...:..|.|.|
  Rat     5 ECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQ 69

  Fly   181 MIFVIIGAG--MAALGFMILFVGFLATGATRYKVYRAWRSRVGGR-ISCAV-------------- 228
              :||.|..  ....|.::|..||..|||.| :::..:::.:.|: :|..|
  Rat    70 --YVIYGTASFFFLYGALLLAEGFYTTGAVR-QIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQ 131

  Fly   229 --------------------LMGITYLLNFVWSLILCFLVVVTFIYTMFWNMC--------TSVE 265
                                .:||||.|..||.|:.....|..:||...|..|        ||..
  Rat   132 AHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSAS 196

  Fly   266 HSQSCIDLTQFHFM----FPPNTKLEDMKVCEKYEIKAFCKDGVENAEV-----MFILATLSTLL 321
            ....|.|...:..:    ||.       |||.. .:.:.||    .||.     :||.|.:....
  Rat   197 IGSLCADARMYGVLPWNAFPG-------KVCGS-NLLSICK----TAEFQMTFHLFIAAFVGAAA 249

  Fly   322 VLLSLVHYLMCLSANYAHIR 341
            .|:||:.:::..:.|:|.::
  Rat   250 TLVSLLTFMIAATYNFAVLK 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
M6	NP_001262166.1	Myelin_PLP	123..345	CDD:279599	67/280 (24%)
Plp1	NP_112252.1	Myelin_PLP	5..273	CDD:396024	67/280 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336056
Domainoid	1	1.000	106	1.000	Domainoid score	I6439
eggNOG	1	0.900	-	-		E1_KOG4800
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	114	1.000	Inparanoid score	I4745
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D390385at33208
OrthoFinder	1	1.000	-	-		FOG0001336
OrthoInspector	1	1.000	-	-		otm45124
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11683
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.860