DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glg1 and Glg1

DIOPT Version :9

Sequence 1:	NP_001262163.1	Gene:	Glg1 / 40382	FlyBaseID:	FBgn0264561	Length:	1107	Species:	Drosophila melanogaster
Sequence 2:	XP_038953604.1	Gene:	Glg1 / 29476	RGDID:	69345	Length:	1193	Species:	Rattus norvegicus

Alignment Length:	1118	Identity:	371/1118 - (33%)
Similarity:	600/1118 - (53%)	Gaps:	96/1118 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LAE---C-QDLKKLCAHHKSTDNLSMLECALTFSSSQLMDL--PEG-----CQNALWMQQRQLQL 96
            |||   | :|:.::|..|..::||::|||        |.|:  ||.     |.:.||..:..|..
  Rat   104 LAEEESCREDVTRVCPKHTWSNNLAVLEC--------LQDVREPENEISSDCNHLLWNYKLNLTT 160

  Fly    97 PAWLESTFLPAYCPAERPKLESC----LNAVHLWSCLEQQRLKLLQNNACHQHLRRAYESLGQDY 157
            ....||. ....|.:...:::.|    :...::.|||...|..:.:.. |||::.:....:..||
  Rat   161 DPKFESV-AREVCKSTISEIKECAEEPVGKGYMVSCLVDHRGNITEYQ-CHQYITKMTAIIFSDY 223

  Fly   158 SAVDEFYTACGPLVEENKCGRLNVDHLPSVLSQLTTVQCL--------QESATKTGIEPVCQAAI 214
            ..:..|...|...:...|||.:.:.. ....||...|.||        :|...|..:..:|:.||
  Rat   224 RLICGFMDDCKNDINLLKCGSIRLGE-KDAHSQGEVVSCLEKGLVKEAEEKEPKIQVSELCKKAI 287

  Fly   215 NSI------------ELFRVCQEDFSSFCSQEKSGTAAGYKCLVRHKNHPSMSSQCSARITLRDQ 267
            ..:            .|:..|::|...||...::|....||||..||...|||.:|...:|.|.:
  Rat   288 LRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEESMSEKCREALTTRQK 352

  Fly   268 QIGRDYRVSHGLAKACKDDIKLYHCR-RGVSEDKHVRLAQILLCLESVSKNGTKLAPPCLTELTD 331
            .|.:||:||:.|||:||.|:|.|.|. ..:...:..||:.:|:||||....|.:::..|..|:.|
  Rat   353 LIAQDYKVSYSLAKSCKSDLKKYRCNVENLPRSREARLSYLLMCLESAVHRGRQVSSECQGEMLD 417

  Fly   332 HRRMLMTDYQLSPELLNDCADDIPKFCPDEHKAQLVNGMTSTGGEIIHCLLEHVKARRPQRRVTA 396
            :|||||.|:.||||::..|..:|...|...|:.          |..:|||::.|:..:..  :..
  Rat   418 YRRMLMEDFSLSPEIILSCRGEIEHHCSGLHRK----------GRTLHCLMKVVRGEKGS--LGM 470

  Fly   397 QCQRGLETLIKASDAGEDWRVDPVLRRACKPVVDVVCRDVQGGEARVMGCLMEHIGTPVMLPDCE 461
            .||:.|:|||:.:|.|.|:|:|..|..||:.|:...|:.::.|:..::.|||||:.|..|:.|||
  Rat   471 NCQQALQTLIQETDPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEKMVEDCE 535

  Fly   462 QALLIIEYFVARDFKLDPQLYKHCRDDAVKYCRAKKQWDDAQNIQMDPERGPMILPCLHRMAF-S 525
            ..||.::||::||:||||.||:.|:.||.:.|.. ..|::...: |.|   ..:..||:|.|: :
  Rat   536 HRLLELQYFISRDWKLDPVLYRKCQGDASRLCHT-HGWNETSEL-MPP---GAVFSCLYRHAYRT 595

  Fly   526 EDEHQTLRKDCFQEVKRVMRQRAISMDLIPEVEDYCLNDLSAFCADCTEKGSEMECLQKNMDQLQ 590
            |::.:.|.::|..||:|::.|||:.:.|.|.::|.||.||..:|::.||.|.|:||||.::|.|.
  Rat   596 EEQGRRLSRECRAEVQRILHQRAMDVKLDPALQDKCLIDLGKWCSEKTETGQELECLQDHLDDLA 660

  Fly   591 PECKTVVVKYTEEEAAHVELNPVIMNVCGEAMQQHCSAILKSGKDNGDMMDCLIAHKNDADLRKD 655
            .||:.:|...||.|:..:::..::|..|...:...|..:..:..|:||:|:|||.:|:..|:.:
  Rat   661 VECRDIVGNLTELESEDIQIEALLMRACEPIIHNFCHDVADNQIDSGDLMECLIQNKHQKDMNE- 724

  Fly   656 LRCRAAIEHFQIISLKSFHFTTKFKEACRPYVQRFCSSSATKNEVVACLSEVMRNDTI-KAQRHQ 719
             :|...:.|||::.:|.|.|:.|||.||:..|.:.|.:...|.:||.|||..:||||: :|:.|:
  Rat   725 -KCAIGVTHFQLVQMKDFRFSYKFKMACKEDVLKLCPNIKKKVDVVICLSTTVRNDTLQEAKEHR 788

  Fly   720 IPKECRHQVKAQLYQQRESIQLDPKLANACKRELEQFCEE-EKGPGQVNEKALECLIRKTHSLGK 783
            :..:||.|::.:..:..|.|:|:|.|..|||.:::.:|.. :.|..|:    :|||......|..
  Rat   789 VSLKCRKQLRVEELEMTEDIRLEPDLYEACKSDIKNYCSTVQYGNAQI----IECLKENKKQLST 849

  Fly   784 PCHHAIFMVKKSELGDSGTDYTLLTTCKEMIYKFCPSTDSSKLLDCLKTYKDDTQFDQRCHLVVV 848
            .||..:|.::::|:.|...||||:..||:||.:|||..||..:|.|||..|:....|.:|..::.
  Rat   850 RCHQRVFKLQETEMMDPELDYTLMRVCKQMIKRFCPEADSKTMLQCLKQNKNSELMDPKCKQMIT 914

  Fly   849 NRMIEQNTDFRFNPSLQSACGKNIDRYCSNIVASALPNEELNGKVIHCLKDKFRQSALDEPCAKE 913
            .|.|.||||:|.||.|:.||..:|.::|..|:..|..:.||.|:||.|||.::....|...|..:
  Rat   915 KRQITQNTDYRLNPVLRKACKADIPKFCHGILTKAKDDSELEGQVISCLKLRYADQRLSSDCEDQ 979

  Fly   914 MIKILQEQALNYKLNPLLQVFCKSEIQELCKANVDSDEH-GQLAECLK-------TAFLQKQIIN 970
            :..|:||.||:|:|:|.||:.|..||..||.....:.|. ||:.||||       |...:|.:.|
  Rat   980 IRIIIQESALDYRLDPQLQLHCSDEIANLCAEEAAAQEQTGQVEECLKVNLLKIRTELCKKSVTN 1044

  Fly   971 RQC-------------QMEVATLIAEAKADIHVDPILETACTVDLLRYCSKVAAGNGRKLNCLRT 1022
            ...             ..||..::.|:||||.|||:|.|||.:|:..:|:.:..|.||:::||..
  Rat  1045 TDWIHFFYKAPHNELPFQEVLNMLKESKADIFVDPVLHTACALDIKHHCAAITPGRGRQMSCLME 1109

  Fly  1023 LLKDTPNSLEADCREKLQRRIEMFRNADDTLALPPEDVQQLVQQVVASPARKFFLVILMSATGLV 1087
            .|:|....|:.:|:::|..||||:..|  ....|.:....|..||:.||::.:.|.::..:..::
  Rat  1110 ALEDKRVRLQPECKKRLNDRIEMWSYA--AKVAPADGFSDLAMQVMTSPSKNYILSVISGSICIL 1172

  Fly  1088 FLTGIFLGRATKR 1100
            ||.|:..||.|||
  Rat  1173 FLIGLMCGRITKR 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glg1	NP_001262163.1	Cys_rich_FGFR	257..319	CDD:279212	24/62 (39%)
		Cys_rich_FGFR	323..386	CDD:279212	21/62 (34%)
		Cys_rich_FGFR	397..454	CDD:279212	22/56 (39%)
		Cys_rich_FGFR	458..527	CDD:279212	26/69 (38%)
		Cys_rich_FGFR	534..590	CDD:279212	24/55 (44%)
		Cys_rich_FGFR	591..651	CDD:279212	17/59 (29%)
		Cys_rich_FGFR	657..712	CDD:279212	22/54 (41%)
		Cys_rich_FGFR	722..781	CDD:279212	17/59 (29%)
		Cys_rich_FGFR	783..838	CDD:279212	23/54 (43%)
		Cys_rich_FGFR	841..903	CDD:279212	25/61 (41%)
		Cys_rich_FGFR	908..967	CDD:279212	24/66 (36%)
		Cys_rich_FGFR	972..1027	CDD:279212	22/67 (33%)
Glg1	XP_038953604.1	Cys_rich_FGFR	146..204	CDD:395676	11/61 (18%)
		Cys_rich_FGFR	207..269	CDD:395676	14/69 (20%)
		Cys_rich_FGFR	283..338	CDD:395676	21/54 (39%)
		Cys_rich_FGFR	341..405	CDD:395676	26/64 (41%)
		Cys_rich_FGFR	410..465	CDD:395676	12/54 (22%)
		Cys_rich_FGFR	472..529	CDD:395676	22/56 (39%)
		Cys_rich_FGFR	532..593	CDD:395676	20/61 (33%)
		Cys_rich_FGFR	605..659	CDD:395676	23/53 (43%)
		Cys_rich_FGFR	662..721	CDD:395676	16/58 (28%)
		Cys_rich_FGFR	724..780	CDD:395676	24/56 (43%)
		Cys_rich_FGFR	792..848	CDD:395676	16/56 (29%)
		Cys_rich_FGFR	850..903	CDD:395676	22/52 (42%)
		Cys_rich_FGFR	907..964	CDD:395676	24/56 (43%)
		Cys_rich_FGFR	975..1030	CDD:395676	24/62 (39%)
		Cys_rich_FGFR	1062..1115	CDD:395676	17/52 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353671
Domainoid	1	1.000	62	1.000	Domainoid score	I10137
eggNOG	1	0.900	-	-		E1_KOG3648
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7533
Inparanoid	1	1.050	686	1.000	Inparanoid score	I676
OMA	1	1.010	-	-		QHG48082
OrthoDB	1	1.010	-	-		D168451at33208
OrthoFinder	1	1.000	-	-		FOG0006098
OrthoInspector	1	1.000	-	-		oto95892
orthoMCL	1	0.900	-	-		OOG6_105731
Panther	1	1.100	-	-	LDO	PTHR11884
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4394
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770