DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glg1 and GLG1

DIOPT Version :9

Sequence 1:	NP_001262163.1	Gene:	Glg1 / 40382	FlyBaseID:	FBgn0264561	Length:	1107	Species:	Drosophila melanogaster
Sequence 2:	NP_036333.2	Gene:	GLG1 / 2734	HGNCID:	4316	Length:	1203	Species:	Homo sapiens

Alignment Length:	1098	Identity:	372/1098 - (33%)
Similarity:	600/1098 - (54%)	Gaps:	78/1098 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LAE---C-QDLKKLCAHHKSTDNLSMLECALTFSSSQLMDL--PEG-----CQNALWMQQRQLQL 96
            |||   | :|:.::|..|..::||::|||        |.|:  ||.     |.:.||..:..|..
Human   112 LAEEESCREDVTRVCPKHTWSNNLAVLEC--------LQDVREPENEISSDCNHLLWNYKLNLTT 168

  Fly    97 PAWLESTFLPAYCPAERPKLESC----LNAVHLWSCLEQQRLKLLQNNACHQHLRRAYESLGQDY 157
            ....||. ....|.:...:::.|    :...::.|||...|..:.:.. |||::.:....:..||
Human   169 DPKFESV-AREVCKSTITEIKECADEPVGKGYMVSCLVDHRGNITEYQ-CHQYITKMTAIIFSDY 231

  Fly   158 SAVDEFYTACGPLVEENKCGRLNVDHLPSVLSQLTTVQCL--------QESATKTGIEPVCQAAI 214
            ..:..|...|...:...|||.:.:.. ....||...|.||        :|...|..:..:|:.||
Human   232 RLICGFMDDCKNDINILKCGSIRLGE-KDAHSQGEVVSCLEKGLVKEAEEREPKIQVSELCKKAI 295

  Fly   215 NSI------------ELFRVCQEDFSSFCSQEKSGTAAGYKCLVRHKNHPSMSSQCSARITLRDQ 267
            ..:            .|:..|::|...||...::|....||||..||...|||.:|...:|.|.:
Human   296 LRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCLFNHKFEESMSEKCREALTTRQK 360

  Fly   268 QIGRDYRVSHGLAKACKDDIKLYHCR-RGVSEDKHVRLAQILLCLESVSKNGTKLAPPCLTELTD 331
            .|.:||:||:.|||:||.|:|.|.|. ..:...:..||:.:|:||||....|.:::..|..|:.|
Human   361 LIAQDYKVSYSLAKSCKSDLKKYRCNVENLPRSREARLSYLLMCLESAVHRGRQVSSECQGEMLD 425

  Fly   332 HRRMLMTDYQLSPELLNDCADDIPKFCPDEHKAQLVNGMTSTGGEIIHCLLEHVKARRPQRRVTA 396
            :|||||.|:.||||::..|..:|...|...|:.          |..:|||::.|:..:  ..:..
Human   426 YRRMLMEDFSLSPEIILSCRGEIEHHCSGLHRK----------GRTLHCLMKVVRGEK--GNLGM 478

  Fly   397 QCQRGLETLIKASDAGEDWRVDPVLRRACKPVVDVVCRDVQGGEARVMGCLMEHIGTPVMLPDCE 461
            .||:.|:|||:.:|.|.|:|:|..|..||:.|:...|:.::.|:..::.|||||:.|..|:.|||
Human   479 NCQQALQTLIQETDPGADYRIDRALNEACESVIQTACKHIRSGDPMILSCLMEHLYTEKMVEDCE 543

  Fly   462 QALLIIEYFVARDFKLDPQLYKHCRDDAVKYCRAKKQWDDAQNIQMDPERGPMILPCLHRMAF-S 525
            ..||.::||::||:||||.||:.|:.||.:.|.. ..|::.....  |:..  :..||:|.|: :
Human   544 HRLLELQYFISRDWKLDPVLYRKCQGDASRLCHT-HGWNETSEFM--PQGA--VFSCLYRHAYRT 603

  Fly   526 EDEHQTLRKDCFQEVKRVMRQRAISMDLIPEVEDYCLNDLSAFCADCTEKGSEMECLQKNMDQLQ 590
            |::.:.|.::|..||:|::.|||:.:.|.|.::|.||.||..:|::.||.|.|:||||.::|.|.
Human   604 EEQGRRLSRECRAEVQRILHQRAMDVKLDPALQDKCLIDLGKWCSEKTETGQELECLQDHLDDLV 668

  Fly   591 PECKTVVVKYTEEEAAHVELNPVIMNVCGEAMQQHCSAILKSGKDNGDMMDCLIAHKNDADLRKD 655
            .||:.:|...||.|:..:::..::|..|...:|..|..:..:..|:||:|:|||.:|:..|:.:
Human   669 VECRDIVGNLTELESEDIQIEALLMRACEPIIQNFCHDVADNQIDSGDLMECLIQNKHQKDMNE- 732

  Fly   656 LRCRAAIEHFQIISLKSFHFTTKFKEACRPYVQRFCSSSATKNEVVACLSEVMRNDTI-KAQRHQ 719
             :|...:.|||::.:|.|.|:.|||.||:..|.:.|.:...|.:||.|||..:||||: :|:.|:
Human   733 -KCAIGVTHFQLVQMKDFRFSYKFKMACKEDVLKLCPNIKKKVDVVICLSTTVRNDTLQEAKEHR 796

  Fly   720 IPKECRHQVKAQLYQQRESIQLDPKLANACKRELEQFCEE-EKGPGQVNEKALECLIRKTHSLGK 783
            :..:||.|::.:..:..|.|:|:|.|..|||.:::.||.. :.|..|:    :|||......|..
Human   797 VSLKCRRQLRVEELEMTEDIRLEPDLYEACKSDIKNFCSAVQYGNAQI----IECLKENKKQLST 857

  Fly   784 PCHHAIFMVKKSELGDSGTDYTLLTTCKEMIYKFCPSTDSSKLLDCLKTYKDDTQFDQRCHLVVV 848
            .||..:|.::::|:.|...||||:..||:||.:|||..||..:|.|||..|:....|.:|..::.
Human   858 RCHQKVFKLQETEMMDPELDYTLMRVCKQMIKRFCPEADSKTMLQCLKQNKNSELMDPKCKQMIT 922

  Fly   849 NRMIEQNTDFRFNPSLQSACGKNIDRYCSNIVASALPNEELNGKVIHCLKDKFRQSALDEPCAKE 913
            .|.|.||||:|.||.|:.||..:|.::|..|:..|..:.||.|:||.|||.::....|...|..:
Human   923 KRQITQNTDYRLNPMLRKACKADIPKFCHGILTKAKDDSELEGQVISCLKLRYADQRLSSDCEDQ 987

  Fly   914 MIKILQEQALNYKLNPLLQVFCKSEIQELCKANVDSDEH-GQLAECLKTAFLQKQIINRQCQMEV 977
            :..|:||.||:|:|:|.||:.|..||..||.....:.|. ||:.||||...|  :|....|:.||
Human   988 IRIIIQESALDYRLDPQLQLHCSDEISSLCAEEAAAQEQTGQVEECLKVNLL--KIKTELCKKEV 1050

  Fly   978 ATLIAEAKADIHVDPILETACTVDLLRYCSKVAAGNGRKLNCLRTLLKDTPNSLEADCREKLQRR 1042
            ..::.|:||||.|||:|.|||.:|:..:|:.:..|.||:::||...|:|....|:.:|:::|..|
Human  1051 LNMLKESKADIFVDPVLHTACALDIKHHCAAITPGRGRQMSCLMEALEDKRVRLQPECKKRLNDR 1115

  Fly  1043 IEMFRNADDTLALPPEDVQQLVQQVVASPARKFFLVILMSATGLVFLTGIFLGRATKR 1100
            |||:..|  ....|.:....|..||:.||::.:.|.::..:..::||.|:..||.|||
Human  1116 IEMWSYA--AKVAPADGFSDLAMQVMTSPSKNYILSVISGSICILFLIGLMCGRITKR 1171

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glg1	NP_001262163.1	Cys_rich_FGFR	257..319	CDD:279212	24/62 (39%)
		Cys_rich_FGFR	323..386	CDD:279212	21/62 (34%)
		Cys_rich_FGFR	397..454	CDD:279212	22/56 (39%)
		Cys_rich_FGFR	458..527	CDD:279212	25/69 (36%)
		Cys_rich_FGFR	534..590	CDD:279212	24/55 (44%)
		Cys_rich_FGFR	591..651	CDD:279212	18/59 (31%)
		Cys_rich_FGFR	657..712	CDD:279212	22/54 (41%)
		Cys_rich_FGFR	722..781	CDD:279212	18/59 (31%)
		Cys_rich_FGFR	783..838	CDD:279212	23/54 (43%)
		Cys_rich_FGFR	841..903	CDD:279212	25/61 (41%)
		Cys_rich_FGFR	908..967	CDD:279212	24/59 (41%)
		Cys_rich_FGFR	972..1027	CDD:279212	23/54 (43%)
GLG1	NP_036333.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..112		372/1098 (34%)
		Cys-rich GLG1 1	116..149		12/40 (30%)
		Cys-rich GLG1 2	150..212		12/62 (19%)
		Cys_rich_FGFR	154..212	CDD:279212	12/58 (21%)
		Cys-rich GLG1 3	215..278		15/64 (23%)
		Cys_rich_FGFR	215..277	CDD:279212	15/63 (24%)
		Cys-rich GLG1 4	286..346		15/59 (25%)
		Cys_rich_FGFR	291..346	CDD:279212	15/54 (28%)
		Cys-rich GLG1 5	347..413		26/65 (40%)
		Cys_rich_FGFR	349..413	CDD:279212	24/63 (38%)
		Cys-rich GLG1 6	414..473		22/68 (32%)
		Cys_rich_FGFR	418..473	CDD:279212	22/64 (34%)
		Cys-rich GLG1 7	475..537		23/61 (38%)
		Cys_rich_FGFR	480..537	CDD:279212	23/56 (41%)
		Cys-rich GLG1 8	538..604		26/70 (37%)
		Cys_rich_FGFR	540..601	CDD:279212	24/65 (37%)
		Cys-rich GLG1 9	609..668		25/58 (43%)
		Cys_rich_FGFR	613..667	CDD:279212	24/53 (45%)
		Cys_rich_FGFR	670..729	CDD:279212	18/58 (31%)
		Cys-rich GLG1 10	670..728		18/57 (32%)
		Cys-rich GLG1 11	729..788		23/60 (38%)
		Cys_rich_FGFR	732..788	CDD:279212	22/57 (39%)
		Cys-rich GLG1 12	796..856		18/63 (29%)
		Cys_rich_FGFR	800..856	CDD:279212	18/59 (31%)
		Cys_rich_FGFR	858..911	CDD:279212	23/52 (44%)
		Cys-rich GLG1 13	858..911		23/52 (44%)
		Cys-rich GLG1 14	912..979		26/66 (39%)
		Cys_rich_FGFR	915..972	CDD:279212	23/56 (41%)
		Cys-rich GLG1 15	980..1035		22/54 (41%)
		Cys_rich_FGFR	983..1038	CDD:279212	23/54 (43%)
		Cys-rich GLG1 16	1041..1101		25/59 (42%)
		Cys_rich_FGFR	1046..1101	CDD:279212	24/54 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159621
Domainoid	1	1.000	62	1.000	Domainoid score	I10430
eggNOG	1	0.900	-	-		E1_KOG3648
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7533
Inparanoid	1	1.050	690	1.000	Inparanoid score	I697
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48082
OrthoDB	1	1.010	-	-		D168451at33208
OrthoFinder	1	1.000	-	-		FOG0006098
OrthoInspector	1	1.000	-	-		oto88757
orthoMCL	1	0.900	-	-		OOG6_105731
Panther	1	1.100	-	-	LDO	PTHR11884
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5558
SonicParanoid	1	1.000	-	-		X4394
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800