Protein Alignment Est-Q and CES2

DIOPT Version :9

• Sequence 1: NP_649321.1
• Gene: Est-Q / 40381
• FlyBaseID: FBgn0037090
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_001352334.1
• Gene: CES2 / 8824
• HGNCID: 1864
• Length: 559
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 163/562 - (29%)
• Similarity: 252/562 - (44%)
• Gaps: 84/562 - (14%)

  Fly    16 LTAGLTAF---LVIFLTGGQGADASETATVTVELYNGQGTVLGNYAYTAWTDRAFMQFRGIPFAE 77
            |.|.|:|.   |::.|..|||.|::.....|   :.||  |||:..:....:.....|.|||||:
Human     6 LRARLSAVACGLLLLLVRGQGQDSASPIRTT---HTGQ--VLGSLVHVKGANAGVQTFLGIPFAK 65

  Fly    78 PPIEELRFRPPVARSPWTGTLNALNFGQRC-PVITNLDSQM---------SDAELEDCLTLSVYT 132
            ||:..|||.||.....|:|..:.......| ..:|.::|:.         ||:..||||.||:||
Human    66 PPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYT 130

  Fly   133 ---KNLSASQPVMFYIYGGGFYNGSSEDHPPNYLLE-KDVVLVVPQYRVGALGWLSTYTEELPGN 193
               .:..::.|||.:|:||....|.:..:..:.|.. ::||:|:.|||:|.||:.||..:...||
Human   131 PAHSHEGSNLPVMVWIHGGALVFGMASLYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGN 195

  Fly   194 APIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFA 258
            ....|.:.||.|||.:|:.|||:|.:|||||:|||....|||::|| ....:|..||::||....
Human   196 WGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSP-ISQGLFHGAIMESGVALL 259

  Fly   259 SWAINKDPKAQSRRICIQLGCSGCEQHDQ--LVKCIQKAKVIDILKATASESFSPIVGDLHGI-L 320
            ...|.......|   .:....|.|:|.|.  ||.|::.....:||  ..::.|..|.|.:.|: |
Human   260 PGLIASSADVIS---TVVANLSACDQVDSEALVGCLRGKSKEEIL--AINKPFKMIPGVVDGVFL 319

  Fly   321 PQQPSELVKSYRRQ-IPILTGFTQHDGSFVLAS---YYDAL------AAKVANVSSLSVRQFSQG 375
            |:.|.||:.|...| :|.:.|...::..:::..   .||..      |::.|....|::......
Human   320 PRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQKEMDREASQAALQKMLTLLMLPPT 384

  Fly   376 INDLVNDTSGLTDNILNRLLFKPQALNSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRST 440
            ..||:.: ..:.||      ..||.|.:........|.|.:        |.:.:|   :.|....
Human   385 FGDLLRE-EYIGDN------GDPQTLQAQFQEMMADSMFVI--------PALQVA---HFQCSRA 431

  Fly   441 PVYVYSFEYEGTYTR----------FGYEFGNSHYPFNGGVHHSNDNIYLFATHPLEGQDTQMSQ 495
            |||.|.|:::.::.:          .|.|.......|.||      |...|..     ::.|:|:
Human   432 PVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFFGG------NYIKFTE-----EEEQLSR 485

  Fly   496 KMVDVWTSFAIEGVPRNLS----PLSSASGPYNKLNLEVTKG 533
            ||:..|.:||..|.|....    ||......|.:|||:...|
Human   486 KMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVG 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	153/536 (29%)
		Aes	<137..>240	CDD:223730	44/103 (43%)
CES2	NP_001352334.1	COesterase	30..538	CDD:306613	153/538 (28%)
		Prevents secretion from ER. /evidence=ECO:0000255	556..559

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810