DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and Ces2j

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_038953911.1	Gene:	Ces2j / 685645	RGDID:	1591368	Length:	576	Species:	Rattus norvegicus

Alignment Length:	560	Identity:	149/560 - (26%)
Similarity:	248/560 - (44%)	Gaps:	87/560 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 GVLTAGLTAFLVIFLTGGQGADASETATVTVELYNGQGTVLGNYAYTAWTDRAFMQFRGIPFAEP 78
            |:..:.|.:||.     .||.|::.....|   :.||  |.|::.:...|......|.|||||:|
  Rat    32 GIPDSNLHSFLT-----EQGQDSASPIRNT---HTGQ--VRGSFVHVKDTKSGIHTFLGIPFAKP 86

  Fly    79 PIEELRFRPPVARSPWTGTLNALNFGQRC--PVITNLDSQMSDAEL------EDCLTLSVYT--- 132
            |:..|||.||....||:|..:|.:....|  ..:.||:. |.:.||      ||||.|::|.
  Rat    87 PVGPLRFAPPEDPEPWSGVRDATSQPAMCLQTAMMNLEG-MKETELTKLPMSEDCLYLNIYVPAH 150

  Fly   133 KNLSASQPVMFYIYGGGFYNGSSEDHPPNYL-LEKDVVLVVPQYRVGALGWLSTYTEELPGNAPI 196
            .:..::.|||.:|:|||...||:..:..:.| ..:::|:|..|||:|.||:.||..:...||...
  Rat   151 AHEDSNLPVMVWIHGGGLVGGSASMNDASTLAATEEIVIVSIQYRLGVLGFFSTGDQHARGNWGY 215

  Fly   197 ADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWA 261
            .|.:.||.|||.:|:.|||:...|||||.|||....||.::||.: ..:|.|||:|||.......
  Rat   216 LDQMAALRWVQQNIAYFGGNRDSVTIFGVSAGGTSVSSHVVSPMS-KGLFHRAIMQSGVALLPGL 279

  Fly   262 INKDPKAQSRRICIQLGCSGCEQHDQ--LVKCIQKAKVIDILKATASESFSPIVGDLHG-ILPQQ 323
            |:...:...:.:.   ..||||..|.  |::|::.....:||  ..::.|..|.|.:.| .||:.
  Rat   280 ISDTSEVVYKTVA---NLSGCEASDSEALIRCLRAKSKQEIL--AINQVFKMIPGVVDGKFLPKH 339

  Fly   324 PSELVKSYR-RQIPILTGFTQHDGSF----VLASYYDALAAKVANVSSLSVRQFSQGINDLVNDT 383
            |.||:.|.. ..:|.:.|....:..:    :|..|:.                    ||::..:|
  Rat   340 PQELLASKDFHPVPSIIGVNTDECGWGVPTILGLYHI--------------------INNITRET 384

  Fly   384 SGLTDNI-LNRLLFKPQAL---------NSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQR 438
            ......| ..:::..|:.:         ::.|.....:.:.::..:.....|.:.:|   :.|:.
  Rat   385 LPAALKIAAAQMMLPPECIDLIMEEYMGDTEDAETLQAQFKEMLGDFIFVIPALQVA---HFQRS 446

  Fly   439 STPVYVYSFEYEGTYTRFGYEFGNSHYPFNGGVHHSNDNIYLFA------THPLEGQDTQMSQKM 497
            ..|||.|.|::.       ..|.....||.....|.:|.:::|.      |..|..::..:.:::
  Rat   447 QAPVYFYEFQHL-------LSFIKQVRPFYPKADHGDDTVFVFGSYFWGMTFDLTEEEELLKRRV 504

  Fly   498 VDVWTSFAIEGVPRNLS----PLSSASGPYNKLNLEVTKG 533
            :..|.:||..|.|....    |:......|.:||.:...|
  Rat   505 MKYWANFARTGNPNGEDLPHWPVLDHDEQYLQLNSQPAVG 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	142/535 (27%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	43/103 (42%)
Ces2j	XP_038953911.1	COesterase	50..555	CDD:395084	142/537 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810