DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and Bche

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_075231.1	Gene:	Bche / 65036	RGDID:	619996	Length:	597	Species:	Rattus norvegicus

Alignment Length:	510	Identity:	148/510 - (29%)
Similarity:	235/510 - (46%)	Gaps:	75/510 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 FRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRCPVITNLD--------SQMSDAEL---E 123
            |.|||:|:||:..|||:.|...:.|....||..:...|  ..|:|        |:|.:...   |
  Rat    51 FLGIPYAQPPLGSLRFKKPQPLNKWPDVYNATKYANSC--YQNIDQAFPGFQGSEMWNPNTNLSE 113

  Fly   124 DCLTLSVY-----TKNLSASQPVMFYIYGGGFYNGSSE--DHPPNYLLEKDVVLVVP-QYRVGAL 180
            |||.|:|:     .||.:    ||.::|||||..|:|.  .:...:|...:.|:||. .||||||
  Rat   114 DCLYLNVWIPVPKPKNAT----VMVWVYGGGFQTGTSSLPVYDGKFLTRVERVIVVSMNYRVGAL 174

  Fly   181 GWLS-TYTEELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDN 244
            |:|: ....|.|||..:.|..:||.|:|.:|::|||:|:.||:||:||||...|..||.|::..
  Rat   175 GFLAFPGNSEAPGNMGLFDQQLALQWIQRNIAAFGGNPKSVTLFGESAGAASVSLHLLCPQSYP- 238

  Fly   245 MFKRAIVQSGSIFASWAINKDPKAQSRRICIQ--LGCSGCEQHDQLVKCIQKAKVIDIL------ 301
            :|.|||::|||..|.||:....:|::|.:.:.  :|||. |...:::.|::.....:||
  Rat   239 LFTRAILESGSSNAPWAVKHPEEARNRTLTLAKFIGCSK-ENEKEIITCLRSKDPQEILLNEKLV 302

  Fly   302 ---KATASESFSPIV-GDLHGILPQQPSELVKSYRRQIPILTGFTQHDGSFVLASYYDALAAKVA 362
               .:..|.:|.|.| ||....:|....:|.|....|  ||.|..:.:|:..|.  |.|......
  Rat   303 LPSDSIRSINFGPTVDGDFLTDMPHTLLQLGKVKTAQ--ILVGVNKDEGTAFLV--YGAPGFSKD 363

  Fly   363 NVSSLSVRQFSQGINDLVNDTSGLTDNILNRLLFKPQALNSHDHSAAVSSYFDLTTNIFMKSPVI 427
            |.|.::.|:|.:|:|......|.|....:  |.:....|..........::.|:..:..:..|.:
  Rat   364 NDSLITRREFQEGLNMYFPGVSSLGKEAI--LFYYVDWLGDQTPEVYREAFDDIIGDYNIICPAL 426

  Fly   428 TLATKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGNSHYPFNG--GVHHSNDNIYLFATHPLEGQ- 489
            .. ||.:.:......:.|            :|..:|..|:..  ||.|..:..::|.. |||.:
  Rat   427 EF-TKKFAELEINAFFYY------------FEHRSSKLPWPEWMGVMHGYEIEFVFGL-PLERRV 477

  Fly   490 -----DTQMSQKMVDVWTSFAIEGVPRNLS------PL-SSASGPYNKLNLEVTK 532
                 :...|:.::..|.:||..|.|....      |: :|....|..||.|.:|
  Rat   478 NYTRAEEIFSRSIMKTWANFAKYGHPNGTQGNSTVWPVFTSTEQKYLTLNTEKSK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	148/510 (29%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	46/106 (43%)
Bche	NP_075231.1	COesterase	21..545	CDD:278561	148/510 (29%)
		Aes	<120..>272	CDD:223730	62/156 (40%)
		AChE_tetra	560..594	CDD:285837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910