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Protein Alignment Est-Q and BCHE

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_000046.1	Gene:	BCHE / 590	HGNCID:	983	Length:	602	Species:	Homo sapiens

Alignment Length:	576	Identity:	171/576 - (29%)
Similarity:	264/576 - (45%)	Gaps:	120/576 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 FLVIFLTGGQGADASETATVTVELYNGQGTVLG-NYAYTAWTDRAFMQFRGIPFAEPPIEELRFR 86
            ||::.:..|:.....:....|     ..|.|.| |......|..||:   |||:|:||:..|||:
Human    16 FLLLCMLIGKSHTEDDIIIAT-----KNGKVRGMNLTVFGGTVTAFL---GIPYAQPPLGRLRFK 72

  Fly    87 PPVARSPWTGTLNALNFGQRCPVITNLD--------SQM--SDAEL-EDCLTLSVYTKNLSASQP 140
            .|.:.:.|:...||..:...|  ..|:|        |:|  .:.:| ||||.|:|:   :.|.:|
Human    73 KPQSLTKWSDIWNATKYANSC--CQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVW---IPAPKP 132

  Fly   141 ----VMFYIYGGGFYNGSSEDH--PPNYLLEKDVVLVVP-QYRVGALGWLS-TYTEELPGNAPIA 197
                |:.:||||||..|:|..|  ...:|...:.|:||. .|||||||:|: ....|.|||..:.
Human   133 KNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLF 197

  Fly   198 DILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAI 262
            |..:||.|||.:|::|||:|:.||:||:||||...|..||||.: .::|.|||:||||..|.||:
Human   198 DQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGS-HSLFTRAILQSGSFNAPWAV 261

  Fly   263 NKDPKAQSRRICIQ--LGCSGCEQHDQLVKCIQKAKVIDILKATA---------SESFSPIV-GD 315
            ....:|::|.:.:.  .|||. |...:::||::.....:||...|         |.:|.|.| ||
Human   262 TSLYEARNRTLNLAKLTGCSR-ENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGD 325

  Fly   316 LHGILPQQPSELVKSYRRQIPILTGFTQHDGSFVLASYYDALAAKVANVSSLSVRQFSQGINDLV 380
            ....:|....||.:..:.|  ||.|..:.:|:..|.  |.|......|.|.::.::|.:|:.
Human   326 FLTDMPDILLELGQFKKTQ--ILVGVNKDEGTAFLV--YGAPGFSKDNNSIITRKEFQEGLK--- 383

  Fly   381 NDTSGLTDNILNRLLFKPQALNSHDHSAAVSSY------FDLTTNIFMKSPVITLATKMYTQQRS 439
                          :|.|          .||.:      |..|..:..:.|      :.|.:...
Human   384 --------------IFFP----------GVSEFGKESILFHYTDWVDDQRP------ENYREALG 418

  Fly   440 TPVYVYSF-----EYEGTYTRFG-------YEFGNSHYPFNG--GVHHSNDNIYLFATHPLEGQD 490
            ..|..|:|     |:...::.:|       :|..:|..|:..  ||.|..:..::|.. |||.:|
Human   419 DVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGL-PLERRD 482

  Fly   491 TQ------MSQKMVDVWTSFAIEGVPRNLSPLSSASGP--------YNKLNLEVTK 532
            ..      :|:.:|..|.:||..|.| |.:..:|.|.|        |..||.|.|:
Human   483 NYTKAEEILSRSIVKRWANFAKYGNP-NETQNNSTSWPVFKSTEQKYLTLNTESTR 537

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.