Protein Alignment Est-Q and NLGN2

DIOPT Version :10

• Sequence 1: NP_649321.1
• Gene: Est-Q / 40381
• FlyBaseID: FBgn0037090
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_065846.1
• Gene: NLGN2 / 57555
• HGNCID: 14290
• Length: 835
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 150/599 - (25%)
• Similarity: 250/599 - (41%)
• Gaps: 141/599 - (23%)

  Fly     9 MLTLCGVLTAGLTAFLVIFLTGGQGADASETATVTVELYNGQGTVLGN------------YAYTA 61
            :|.||.|..||....     .||.|..|.          .|.|..||:            |....
Human     3 LLALCLVGLAGAQRG-----GGGPGGGAP----------GGPGLGLGSLGEERFPVVNTAYGRVR 52

  Fly    62 WTDRAF--------MQFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRCP---------- 108
            ...|..        :||.|:|:|.||:...||:||.|.:.|.|..||......||
Human    53 GVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAI 117

  Fly   109 -----VITNLDSQMS--DAELEDCLTLSVY--------TKNLS--------------ASQPVMFY 144
                 ...||::..:  ..:.||||.|::|        ||...              ..:|||.:
Human   118 MLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDPGKKPVMLF 182

  Fly   145 IYGGGFYNGSSEDHPPNYLLE-KDVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMALDWVQM 208
            ::||.:..|:......:.|.. .:|::....||:|.||:|||..:...||..:.|.:.||.|:..
Human   183 LHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSE 247

  Fly   209 HISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPKAQSRRI 273
            :|:.|||||:::||||..|||...:.|:||..: :.:|::||.|||:..:||::|..|...:|.:
Human   248 NIAHFGGDPERITIFGSGAGASCVNLLILSHHS-EGLFQKAIAQSGTAISSWSVNYQPLKYTRLL 311

  Fly   274 CIQLGCSGCEQHDQLVKCIQK---AKVI--DILKATASESFSPIV-GDLHGILPQQPSELVK--- 329
            ..::||.. |...:.|:|:::   .:::  |:..|....:|.|:| ||   ::|..|..|::
Human   312 AAKVGCDR-EDSAEAVECLRRKPSRELVDQDVQPARYHIAFGPVVDGD---VVPDDPEILMQQGE 372

  Fly   330 --SYRRQIPILTGFTQHDG-SFVLASYYDALAAKVANVSSLSVRQFSQGINDLVNDTSGLTD--N 389
              :|    .:|.|..|.:| .||..|        ..:...:|...|...:::.|::..|..:  :
Human   373 FLNY----DMLIGVNQGEGLKFVEDS--------AESEDGVSASAFDFTVSNFVDNLYGYPEGKD 425

  Fly   390 ILN---RLLFKPQALNSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVYVYSF---- 447
            :|.   :.::...| :..:......:...|.|:....:|.:..| |::...:| |||.|:|
Human   426 VLRETIKFMYTDWA-DRDNGEMRRKTLLALFTDHQWVAPAVATA-KLHADYQS-PVYFYTFYHHC 487

  Fly   448 EYEGTYTRFGYEFGNSHYPFNGGVHHSNDNIYLFATHPLEG-----------QDTQMSQKMVDVW 501
            :.||.             |......|.::..|:|.. |:.|           .|..:|..::..|
Human   488 QAEGR-------------PEWADAAHGDELPYVFGV-PMVGATDLFPCNFSKNDVMLSAVVMTYW 538

  Fly   502 TSFAIEGVPRNLSP 515
            |:||..|.|....|
Human   539 TNFAKTGDPNQPVP 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	50..536	CDD:395084	139/558 (25%)
NLGN2	NP_065846.1	COesterase	42..601	CDD:395084	136/545 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..668
		Required for interaction with LHFPL4. /evidence=ECO:0000250|UniProtKB:Q69ZK9	678..698
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	790..835