Protein Alignment Est-Q and NLGN4X

DIOPT Version :10

• Sequence 1: NP_649321.1
• Gene: Est-Q / 40381
• FlyBaseID: FBgn0037090
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: XP_005274621.1
• Gene: NLGN4X / 57502
• HGNCID: 14287
• Length: 836
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 138/521 - (26%)
• Similarity: 234/521 - (44%)
• Gaps: 105/521 - (20%)

  Fly    69 QFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRCP----------------VITNLDSQM 117
            |:.|:|:|.||..|.||:||...|.|||..|...|...||                ...|||:.|
Human    72 QYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDMLPIWFTANLDTLM 136

  Fly   118 S--DAELEDCLTLSVYT---------KNL-----------------SASQPVMFYIYGGGFYNGS 154
            :  ..:.||||.|::|.         ||.                 ::.:|||.||:||.:..|:
Human   137 TYVQDQNEDCLYLNIYVPTEDGANTKKNADDITSNDRGEDEDIHDQNSKKPVMVYIHGGSYMEGT 201

  Fly   155 SEDHPPNYLLE-KDVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQ 218
            ......:.|.. .:|:::...||:|.||:|||..:...||..:.|.:.||.|::.::.:|||||:
Human   202 GNMIDGSILASYGNVIVITINYRLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPK 266

  Fly   219 KVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPKAQSRRICIQLGCSGCE 283
            :|||||..|||...|.|.|| ...:.:|::||:|||:..:|||:|..|...:|.:..::||:..:
Human   267 RVTIFGSGAGASCVSLLTLS-HYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRILADKVGCNMLD 330

  Fly   284 QHDQLVKCIQKAKVIDILK-----ATASESFSPIV-GDLHGILPQQPSELVK-----SYRRQIPI 337
            ..| :|:|::.....::::     ||...:|.|:: ||   ::|..|..|::     :|    .|
Human   331 TTD-MVECLRNKNYKELIQQTITPATYHIAFGPVIDGD---VIPDDPQILMEQGEFLNY----DI 387

  Fly   338 LTGFTQHDGSFVLASYYDALAAKVANVSSLSVRQFSQGINDLVNDTSG-------LTDNILNRLL 395
            :.|..|.:|    ..:.|.:   |.|...::...|...:::.|::..|       |.:.|  :.:
Human   388 MLGVNQGEG----LKFVDGI---VDNEDGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETI--KFM 443

  Fly   396 FKPQALNSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEGTYTRFGYEF 460
            :...| :..:......:...|.|:....:|.:  ||.....|..:|.|.|:| |....:.....:
Human   444 YTDWA-DKENPETRRKTLVALFTDHQWVAPAV--ATADLHAQYGSPTYFYAF-YHHCQSEMKPSW 504

  Fly   461 GNSHYPFNGGVHHSNDNIYLFATHPLEG-----------QDTQMSQKMVDVWTSFAIEGVPRNLS 514
            .:|        .|.::..|:|.. |:.|           .|..:|..::..||:||..|.|....
Human   505 ADS--------AHGDEVPYVFGI-PMIGPTELFSCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPV 560

  Fly   515 P 515
            |
Human   561 P 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	50..536	CDD:395084	138/521 (26%)
NLGN4X	XP_005274621.1	COesterase	44..610	CDD:395084	138/521 (26%)