DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and nlgn3b

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_005165239.1	Gene:	nlgn3b / 567415	ZFINID:	ZDB-GENE-060526-197	Length:	846	Species:	Danio rerio

Alignment Length:	550	Identity:	141/550 - (25%)
Similarity:	238/550 - (43%)	Gaps:	118/550 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 QFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRCP---------------VITNLDSQMS 118
            |:.|:|:|.||:.|.||.||.|.|.|:|..||..|...||               ...|:|:..:
Zfish    72 QYLGVPYAAPPVGEKRFMPPDAPSAWSGVRNATRFPPVCPQTVRNAVPDIMMPVWATYNMDTVAT 136

  Fly   119 --DAELEDCLTLSVY---------TKNLSAS----------------QPVMFYIYGGGFYNGSSE 156
              ..:.||||.:::|         |.::||.                :|||.:|:||.:..|:..
Zfish   137 YLQEQSEDCLYMNIYVPTQSGTKRTGDMSADTERTEDDGLRDSRDDPRPVMLFIHGGSYMEGTGN 201

  Fly   157 DHPPNYLLE-KDVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQKV 220
            ....:.|.. .:|:::...||||.||:|||..:...||..:.|.:.||.|:..:|..|||||.:|
Zfish   202 IMDGSVLASYGNVIVITLNYRVGILGFLSTGDQAAKGNYGLLDQIQALRWINKNIGYFGGDPGRV 266

  Fly   221 TIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPKAQSRRICIQLGCSGCEQH 285
            |:||...||...|.|.||..: :.:|.|||:||||..:||::|..|...:|.:..::||:..:..
Zfish   267 TVFGSGIGASCVSLLTLSHHS-EGLFHRAIIQSGSALSSWSVNYQPVKYTRLLAERVGCNVLDTQ 330

  Fly   286 DQLVKCIQKAKVIDILK-----ATASESFSPIV-GDLHGILPQQPSELVK-----SYRRQIPILT 339
            | ||.|:||....::::     |....:|.|:: |||   :|..|..|::     :|    .|:.
Zfish   331 D-LVLCMQKRSYRELVEQEIQPARFHVAFGPVIDGDL---IPDDPEVLMEQGEFLNY----DIML 387

  Fly   340 GFTQHDGSFVLASYYDALAAKVANVSSLSVRQFSQGINDLVNDTSG-------LTDNILNRLLFK 397
            |..|.:|...:....:      .....:|...|...::|.|:...|       |.:.|  :.::.
Zfish   388 GVNQGEGFRFVEGVVE------PEEGGVSGSDFDFTVSDFVDSLYGYPEGKDTLRETI--KFMYT 444

  Fly   398 PQALNSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGN 462
            ..|...:..:...:.....|.:.:::..|:|  ..::.:..| |.:.|:| |....:.....:.:
Zfish   445 DWADRDNPETRRKTLVAMFTDHQWVEPAVVT--ADLHARYGS-PTFFYAF-YHHCQSPMKPPWAD 505

  Fly   463 SHYPFNGGVHHSNDNIYLFATHPLEG-----------QDTQMSQKMVDVWTSFAIEGVPRNLSPL 516
            |        .|.::..|:|.. ||.|           .|..:|..::..||:||..|.|....|.
Zfish   506 S--------AHGDELPYVFGV-PLIGPTELFPCNFSRNDIMLSAVVMTYWTNFAKTGDPNKPVPQ 561

  Fly   517 S----------------SASGPYNKLNLEV 530
            .                :..||:::|.|.:
Zfish   562 DTKFIHTKANRFEEVTWAKYGPHDQLYLHI 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	141/549 (26%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	41/119 (34%)
nlgn3b	XP_005165239.1	COesterase	40..609	CDD:278561	141/549 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810