DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and ces2b

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_021326380.1	Gene:	ces2b / 561967	ZFINID:	ZDB-GENE-041014-96	Length:	1611	Species:	Danio rerio

Alignment Length:	542	Identity:	155/542 - (28%)
Similarity:	236/542 - (43%)	Gaps:	85/542 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 ADASETATVTVELYNGQGTVLGNYAYTAWTDRAFMQFRGIPFAEPPIEELRFRPPVARSPWTGTL 98
            ::..|...|..:|    |::.|:|......|.....:..||||:.|:..||..||.....|.|..
Zfish   549 SERKEGPVVNTKL----GSLRGSYMMAKGKDSVISSYFAIPFAKSPVGPLRLTPPQPADAWQGVR 609

  Fly    99 NALNFGQRC----PVITNLDSQMS-DAEL----EDCLTLSVYTKNLSASQ---PVMFYIYGGGFY 151
            :|......|    .|:.:|.:.|. ..|.    ||||.|::||.:.....   |||.:|:|||..
Zfish   610 DATKQPPMCLQPKEVMVDLLATMPLKTEFPEVSEDCLYLNIYTPSKPGDNKKLPVMVWIHGGGLA 674

  Fly   152 NGSSEDHPPNYLLE-KDVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMALDWVQMHISSFGG 215
            .||:.....:.|.. :|:|:|:.|||:|.||:.||..|..|||..:.|.:.||.|||.:|.||||
Zfish   675 FGSASIFDAHALAAYQDIVVVMVQYRLGLLGFFSTGDEHAPGNYGLLDQVAALQWVQENIHSFGG 739

  Fly   216 DPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPKAQSRRICIQLG-C 279
            ||..||:||:|||...||.|:|||.:. |:|.|||.:||:...:..::.||.:.:|    .|| .
Zfish   740 DPGSVTVFGESAGGVSASLLVLSPLSA-NLFHRAIAESGTAAMNAIMSPDPLSTAR----SLGNV 799

  Fly   280 SGCE--QHDQLVKCIQKAKVIDILKATASESFSPIVGDLHG-ILPQQPSELVKSYR-RQIPILTG 340
            |||:  ...::|.|:.:....||||....:........:.| .||:...||::|.. .::|::||
Zfish   800 SGCDISSTKKIVDCVMQMTEEDILKIAREQVLLRFGVTVDGQFLPKSVDELLQSQEFSKVPLMTG 864

  Fly   341 FTQHDGSFVLASYYDALAAKVA------NVSSLSVRQFSQGINDLVNDTSGLTDNILNRLLFKPQ 399
            .|..||.|.|..:       :|      .::...:..|....|..:.| .||.:.:|...|..
Zfish   865 VTDDDGGFTLPEF-------IAPPGWRDGMTKDQIMPFLPTYNYDLQD-PGLAEIVLKEYLGA-- 919

  Fly   400 ALNSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEGTYTR--------- 455
               :.|.......:.::..:.|...|...||.  |.:....|||:|.|::.....:
Zfish   920 ---TTDKIKIRDGFREIVGDFFFNLPARKLAN--YHRDTGAPVYMYEFQHPAYIFQNKRPSFVGC 979

  Fly   456 ---------FGYEFGNSHYPFNGGVHHSNDNIYLFATHPLEGQDTQMSQKMVDVWTSFAIEGVPR 511
                     |||.|||.|....|               .|..::.::.:..:..|.:||..|.|.
Zfish   980 DHGDELLFVFGYCFGNGHIKVEG---------------ELSKEEQELCKTTMAYWGNFARTGNPN 1029

  Fly   512 NLS----PLSSASGPYNKLNLE 529
            ...    |...|...|..:.||
Zfish  1030 GPGLVEWPKYGAEAEYLGIGLE 1051

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	154/537 (29%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	50/106 (47%)
ces2b	XP_021326380.1	COesterase	27..539	CDD:306613
		COesterase	553..1065	CDD:306613	155/538 (29%)
		COesterase	1079..1592	CDD:306613
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920