DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and nlgn4xa

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_021330915.1	Gene:	nlgn4xa / 561122	ZFINID:	ZDB-GENE-100309-2	Length:	844	Species:	Danio rerio

Alignment Length:	519	Identity:	140/519 - (26%)
Similarity:	234/519 - (45%)	Gaps:	103/519 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 QFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRCP----------------VITNLDSQM 117
            |:.|||:|.||..|.||:||.....|.|..||..|...||                ...|||:.:
Zfish    69 QYLGIPYALPPTGERRFQPPEPPMSWPGIRNATQFAPVCPQFLEDRFLLNDMLPVWFTANLDTVV 133

  Fly   118 S--DAELEDCLTLSVY--TKNLSAS----------------------QPVMFYIYGGGFYNGSSE 156
            :  ..:.||||.|::|  |:::.|:                      :|||.||:||.:..|:..
Zfish   134 TYVQDQSEDCLYLNIYVPTEDVGANKGDDFTNNEGGENKDIHDENGLRPVMVYIHGGSYMEGTGN 198

  Fly   157 DHPPNYLLE-KDVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQKV 220
            ....:.|.. .:|::|...||:|.||:|||..:...||..:.|.:.||.|::.:|.:|.|||::|
Zfish   199 MIDGSILASYGNVIVVTLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWIKENIQAFKGDPKRV 263

  Fly   221 TIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPKAQSRRICIQLGCSGCEQH 285
            ||||..|||...|.|.||..:.| :|::||:|||:..:|||:|..|...:|.:..::||:..:..
Zfish   264 TIFGSGAGASCVSLLTLSHYSED-LFQKAIIQSGTALSSWAVNYQPAKYTRILAEKVGCNMLDSI 327

  Fly   286 DQLVKCIQKAKVIDILKATASE-----SFSPIV-GDLHGILPQQPSELVK-----SYRRQIPILT 339
            | ||:|:|.....::::...::     :|.|:: ||   ::|..|..|::     :|    .|:.
Zfish   328 D-LVECLQNKNYKELIEQYITQAKYHIAFGPVIDGD---VIPDDPQILMEQGEFLNY----DIML 384

  Fly   340 GFTQHDGSFVLASYYDALAAKVANVSSLSVRQFSQGINDLVNDTSG-------LTDNILNRLLFK 397
            |..|.:|    ..:.|.:   |.:...:|...|...::|.|:...|       |.:.|  :.::.
Zfish   385 GVNQGEG----FKFVDGI---VDSEDGVSANDFDFAVSDFVDHLYGYPEGKDTLRETI--KFMYT 440

  Fly   398 PQALNSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGN 462
            ..| :..:......:...|.|:....:|.:  ||.....|..:|.|.|:| |....:.....:.:
Zfish   441 DWA-DKENPETRRKTLVALFTDHQWVAPAV--ATADLHAQYGSPTYFYAF-YHHCQSEMKPSWSD 501

  Fly   463 SHYPFNGGVHHSNDNIYLFATHPLEG-----------QDTQMSQKMVDVWTSFAIEGVPRNLSP 515
            |        .|.::..|:|.. |:.|           .|..:|..::..||:||..|.|....|
Zfish   502 S--------AHGDEVPYVFGI-PMLGPTDLFNCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVP 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	140/519 (27%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	43/125 (34%)
nlgn4xa	XP_021330915.1	COesterase	43..605	CDD:306613	140/519 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810