Protein Alignment Est-Q and NLGN3

DIOPT Version :9

• Sequence 1: NP_649321.1
• Gene: Est-Q / 40381
• FlyBaseID: FBgn0037090
• Length: 559
• Species: Drosophila melanogaster
• Sequence 2: NP_851820.1
• Gene: NLGN3 / 54413
• HGNCID: 14289
• Length: 848
• Species: Homo sapiens
• Alignment Length: 564
• Identity: 145/564 - (25%)
• Similarity: 229/564 - (40%)
• Gaps: 173/564 - (30%)

  Fly    69 QFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRCPVITNLDSQMSDAEL----------- 122
            |:.|:|:|.|||.|.||.||.....|:|..||.:|...||  .|:.:.:.:..|
Human    68 QYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCP--QNIHTAVPEVMLPVWFTANLDIV 130

  Fly   123 --------EDCLTLSVY--TKNL------------------------------------------ 135
                    ||||.|:||  |:::
Human   131 ATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIR 195

  Fly   136 -SASQPVMFYIYGGGFYNGSSEDHPPNYLLE-KDVVLVVPQYRVGALGWLSTYTEELPGNAPIAD 198
             |.::|||.||:||.:..|:......:.|.. .:|:::...||||.||:|||..:...||..:.|
Human   196 DSGAKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLD 260

  Fly   199 ILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSLLLSPKTGDNMFKRAIVQSGSIFASWAIN 263
            .:.||.||..:|:.|||||:::|:||...||...|.|.||..: :.:|:|||:||||..:|||:|
Human   261 QIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHS-EGLFQRAIIQSGSALSSWAVN 324

  Fly   264 KDPKAQSRRICIQLGCSGCEQHDQLVKCIQK--AKVI---DILKATASESFSPIV-GDLHGILPQ 322
            ..|...:..:..::||:..:..| :|.|:::  ||.:   ||..|....:|.|:: ||   ::|.
Human   325 YQPVKYTSLLADKVGCNVLDTVD-MVDCLRQKSAKELVEQDIQPARYHVAFGPVIDGD---VIPD 385

  Fly   323 QPSELVKSYRRQIPILTGFTQHDGSFVLASYYDALAAKVANVSSLSVRQ-----FSQGINDLVND 382
            .|..|::               .|.|:   .||.:         |.|.|     |.:|:.|..:.
Human   386 DPEILME---------------QGEFL---NYDIM---------LGVNQGEGLKFVEGVVDPEDG 423

  Fly   383 TSGLTDNILNRLLFKPQALNSHDHSAAVSSYFDLTTNIF----MKSPVITLATKMYTQ------- 436
            .||.                  |...:||::.|   |::    .|..:......|||.
Human   424 VSGT------------------DFDYSVSNFVD---NLYGYPEGKDTLRETIKFMYTDWADRDNP 467

  Fly   437 --QRSTPVYVY--------SFEYEGTYTRFG---YEFGNSHY------PFNGGVHHSNDNIYLFA 482
              :|.|.|.::        |......:.|:|   |.:...|:      |......|.::..|:|.
Human   468 ETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFG 532

  Fly   483 THPLEG-----------QDTQMSQKMVDVWTSFAIEGVPRNLSP 515
            . |:.|           .|..:|..::..||:||..|.|....|
Human   533 V-PMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVP 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	145/564 (26%)
		Aes	<137..>240	CDD:223730	41/103 (40%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	145/564 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..694

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810