DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and Cesl1

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	XP_038953870.1	Gene:	Cesl1 / 501232	RGDID:	1565666	Length:	596	Species:	Rattus norvegicus

Alignment Length:	518	Identity:	137/518 - (26%)
Similarity:	232/518 - (44%)	Gaps:	97/518 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 QGTVLGNYAYTAWTDRAFMQFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNF----------G 104
            :|.|||.||......::...|.|:|||:||:..|||.||....||:...|...:          |
  Rat    65 KGKVLGKYASLEGVTQSVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTTYPPMCSQDATKG 129

  Fly   105 QRC-PVITNLDSQMSDAELEDCLTLSVYTK---NLSASQPVMFYIYGGGFYNGSSEDHPPNYL-L 164
            ||. .::||...::.....||||.|::||.   ...:..|||.:|:|||...|.:..:....| .
  Rat   130 QRMNDLLTNRKEKVHLQFSEDCLYLNIYTPADFTKDSRMPVMVWIHGGGLTQGGASTYDGQVLSA 194

  Fly   165 EKDVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGA 229
            .::||:|..|||:|..|:.||..|...||....|.:.||.|||.:|::|||||..|||||:|||.
  Rat   195 YENVVVVAIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGG 259

  Fly   230 GVASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPKAQSRRICIQLGCS--------GC---E 283
            ...|.|:||| ...|::.|||.:||.:..:....||.:..:::|....||.        .|   :
  Rat   260 FSVSVLVLSP-LSKNLYHRAISESGVVLITELFTKDVRPAAKQIADMAGCKTTTSAIIVHCLRQK 323

  Fly   284 QHDQLVKCIQKAKVIDI-LKATASESF---SPIVGDLHGILPQQPSELV--KSYRRQIPILTGFT 342
            ..::|::.::|..:|.: .:....||:   |.::.|:  :||:.|.|::  |:: ..:|.:.|..
  Rat   324 TEEELLEIMEKMNLIKLSSQRDTKESYHFLSTVIDDV--VLPKDPKEILAEKNF-NTVPYIVGIN 385

  Fly   343 QHDGSFVLASYYD--------------ALAAKVANVSSL-------SVRQFSQGINDLVNDTSGL 386
            :.:..::|.:...              .|..|.|::..:       ::.::.:|.:|.:....|:
  Rat   386 KQECGWLLPTMMRFVPPDVKLDKKMAIMLLEKFASIYGIPEDIIPVAIEKYRKGSDDPIKIRDGI 450

  Fly   387 TDNILNRLLFKPQALNSHDHSAAVSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEG 451
            ...|.:.|...|..:.|.||..|                             ..|.|||.::|..
  Rat   451 LAFIGDALFCIPSVMVSRDHRDA-----------------------------GAPTYVYEYQYYP 486

  Fly   452 TYTRFGYEFGNSHYPFNGGVHHSNDNIYLFATHPLEG----QDTQMSQKMVDVWTSFAIEGVP 510
            :       |.:...|.:....|::|...:|....|..    ::.::|:.::..|.:||..|.|
  Rat   487 S-------FSSPQRPKDVVGDHADDVYSVFGAPILRDGASEEEIKLSKMVMKFWANFARNGNP 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	137/518 (26%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	46/103 (45%)
Cesl1	XP_038953870.1	COesterase	57..580	CDD:395084	137/518 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000