DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Est-Q and CG10175

DIOPT Version :9

Sequence 1:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster
Sequence 2:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	564	Identity:	165/564 - (29%)
Similarity:	260/564 - (46%)	Gaps:	122/564 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 GTVLGNY-AYTAWTDRAFMQFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRCP---VIT 111
            |.|.|.| .|.:.....:..|:|:.:..||....|||......||:|..:|...||.||   :|
  Fly   161 GKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCPHKNMI- 224

  Fly   112 NLDSQMSDAELEDCLTLSVYTKNL-----SASQ---PVMFYIYGGGFYNGSSED--HPPNYLLEK 166
             ||:...|   ||||.::|:|..:     ||.|   |||.:::||||..||...  :.|:||:.:
  Fly   225 -LDTFKGD---EDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSFGSGNSFLYGPDYLVAE 285

  Fly   167 DVVLVVPQYRVGALGWLSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGV 231
            |:|||...||:|.||:| |...:.|||..:.|.::||.||:.:|::|||||.:|||||:||||..
  Fly   286 DIVLVTLNYRLGPLGFL-TAGPDAPGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGESAGASS 349

  Fly   232 ASSLLLSPKTGDNMFKRAIVQSGSIFASWAINKDPKAQSRRICIQLGCSGCEQHDQLVKCIQKAK 296
            ...||||.: ...:|.|||.||||....|:::.....::.|:...||..|..:.:.::..:::..
  Fly   350 VQLLLLSSQ-AKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLGYVGANKTEDILDFLRRVP 413

  Fly   297 VIDILKA-----TASES-------FSPIVGDL------------HGILPQQPSELVKS--YRRQI 335
            .:.:::|     ||.:.       |.|:|...            ...|.|.||::..|  :...:
  Fly   414 AMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPFLTQHPSDMYHSQNFNSDV 478

  Fly   336 PILTGFTQHDGSFVLASYYDALAAKVANVSSLSVRQFSQGINDLVNDTSGLTDNILNRLLFKPQA 400
            ..:||:..|:                   :.|.:|:..:....|     .:.:|...||:  ||.
  Fly   479 AYMTGYNTHE-------------------AMLFIRRLRKNPQLL-----SIIENDFGRLV--PQD 517

  Fly   401 LN---SHDH-SAAVSSYFDLTTNIFMKS--PVITLATKMYTQQ--RST----------PVYVYSF 447
            ||   |||. :..:.|::..:.::.::|  .:|.|.|.:...|  |.|          |||:|.|
  Fly   518 LNVTESHDRVTREIRSFYLGSKHVGIESVDEMIALLTDLMFLQGIRRTARNHAKFGNAPVYMYRF 582

  Fly   448 EYEGTYTRFGYEFGNSHYPFNGGVHHSNDNIYLF-------ATHPLEGQDTQMSQKMVDVWTSFA 505
            .::|:...:....|   .| ..||.|.::..|||       :..| :..:.|:..:||.:||:||
  Fly   583 SFDGSLGLYKRMLG---IP-RPGVCHGDELGYLFKFGFFNLSLDP-KSMEVQVKNRMVRMWTNFA 642

  Fly   506 IEGVPRNLSPLSSASGPYNKLNLEVTKGDDLLDTLTAAIDDPDN 549
            ..|.|   :|.|.               |.:|.|..|.| ||.|
  Fly   643 KYGSP---TPDSE---------------DPMLTTKWAPI-DPTN 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	161/557 (29%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	52/107 (49%)
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	165/564 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	7	6.860